\documentclass{article}

\usepackage{acro}
\usepackage{csquotes}
\usepackage{chemmacros}

\DeclareAcronym{APA}{
  short = 3-APA ,
  long = \iupac{3-azido-1-propyl|amine}
}
\DeclareAcronym{CuAAC}{
  short = \enquote{click} chemistry ,
  long = copper(I)-catalyzed azide-alkyne cycloaddition
}

\begin{document}

1: \Acl{APA}

2: \Acs{CuAAC}

3: \Acl{CuAAC}

\end{document}
