data_1GGA
# 
loop_
_audit_author.name 
'Vellieux, F.M.D.' 
'Hajdu, J.'        
'Hol, W.G.J.'      
# 
_cell.entry_id           1GGA 
_cell.length_a           135.520 
_cell.length_b           256.270 
_cell.length_c           114.910 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              24 
_cell.pdbx_unique_axis   ? 
# 
_database_PDB_matrix.entry_id          1GGA 
_database_PDB_matrix.origx[1][1]       1.000000 
_database_PDB_matrix.origx[1][2]       0.000000 
_database_PDB_matrix.origx[1][3]       0.000000 
_database_PDB_matrix.origx[2][1]       0.000000 
_database_PDB_matrix.origx[2][2]       1.000000 
_database_PDB_matrix.origx[2][3]       0.000000 
_database_PDB_matrix.origx[3][1]       0.000000 
_database_PDB_matrix.origx[3][2]       0.000000 
_database_PDB_matrix.origx[3][3]       1.000000 
_database_PDB_matrix.origx_vector[1]   0.00000 
_database_PDB_matrix.origx_vector[2]   0.00000 
_database_PDB_matrix.origx_vector[3]   0.00000 
# 
loop_
_database_PDB_remark.id 
_database_PDB_remark.text 
2  
;
RESOLUTION. 3.2  ANGSTROMS.
;
3  
;
REFINEMENT.
  PROGRAM                    X-PLOR
  AUTHORS                    BRUNGER
  R VALUE                    0.176
  RMSD BOND DISTANCES        0.020  ANGSTROMS
  RMSD BOND ANGLES           3.579  DEGREES
;
4  
;
STRUCTURE DETERMINATION BY THE MOLECULAR REPLACEMENT MODEL
WITH THE BACILLUS STEAROTHERMOPHILUS GAPDH COORDINATES
(KINDLY PROVIDED BY ALAN WONACOTT) AND THE INITIAL LAUE
DATA SET.
ASYMMETRIC UNIT CONTENTS:
- ONE GAPDH TETRAMER IN A GENERAL POSITION
- ONE GAPDH HALF TETRAMER IN A SPECIAL POSITION, WITH ITS
  MOLECULAR Q AXIS COINCIDENT WITH THE CRYSTALLOGRAPHIC
  Z AXIS.
;
5  
;
ORIENTATION OF THE BACILLUS STEAROTHERMOPHILUS GAPDH MODEL
AFTER REFINEMENT OF THE ORIENTATION AND TRANSLATION
PARAMETERS WITH THE PROGRAM BRUTE
GENERAL TETRAMER
EULERIAN ANGLES: 53.40 89.26 90.26
TRANSLATION: 20.90 63.90 19.40
SPECIAL HALF TETRAMER
EULERIAN ANGLES: 19.00 90.00 90.00
TRANSLATION: 67.76 00.00 56.15
;
6  
;
ENERGY MINIMIZATION OF THE MOLECULAR REPLACEMENT SOLUTION
USING GROMOS AND THE INITIAL LAUE DATA SET.
250 STEPS OF STEEPEST DESCENT ENERGY MINIMIZATION WITH
7.0 TO 4.0 A DATA REDUCED THE R-FACTOR FROM 43.1% TO
31.2% (R FACTOR = 36.5% WITH 7.0 TO 3.2 A DATA).
THE ENERGY MINIMIZED COORDINATES WERE AVERAGED OVER THE
SIX SUBUNITS, TO GENERATE A SINGLE, AVERAGED SUBUNIT.
THE MODEL WAS THEN "MUTATED" TO THE T. BRUCEI GAPDH
SEQUENCE USING THE MUTATE OPTION OF THE PROGRAM WHATIF.
THE ORIGINAL, AVERAGED INDIVIDUAL ISOTROPIC TEMPERATURE
FACTORS OF THE BACILLUS MODEL WERE USED FOR THE CONSERVED
RESIDUES AND FOR THE EQUIVALENT ATOMS OF MUTATED RESIDUES.
INSERTIONS WERE ADDED "MANUALLY" WITH FRODO (SUBUNIT "R").
;
7  
;
THE NON-CRYSTALLOGRAPHIC SYMMETRY OPERATIONS WERE APPLIED
TO THIS SUBUNIT "R" TO GENERATE BACK THE CONTENTS OF THE
ASYMMETRIC UNIT (SUBUNITS O, P, Q, R OF THE GENERAL
TETRAMER, AND SUBUNITS A, B OF THE SPECIAL HALF TETRAMER).
;
8  
;
DENSITY MODIFICATION USING THE INITIAL LAUE DATA SET.  THE
COORDINATES WERE USED TO DEFINE A MOLECULAR ENVELOPE FOR
ITERATIVE ELECTRON DENSITY MODIFICATION (7.0 TO 3.2 A
DATA):
- 11 CYCLES OF SOLVENT FLATTENING;
- 36 CYCLES OF 6-FOLD AVERAGING, DURING WHICH THE 63%
  MISSING DATA WERE GRADUALLY REPLACED BY MAP INVERSION
  STRUCTURE FACTOR AMPLITUDES AND PHASES.
THE MODEL FOR SUBUNIT "R" WAS REBUILT IN THE AVERAGED MAP
OBTAINED AT COMPLETION OF THE DENSITY MODIFICATION
PROCEDURE.
;
9  
;
REFINEMENT WITH X-PLOR.
FIVE ROUNDS OF X-PLOR REFINEMENT WERE CARRIED OUT WITH 7.0
TO 3.2 ANGSTROM DATA. NO SIGMA CUTOFFS WERE USED.

ROUND 1, WITH THE INITIAL LAUE DATA SET
 - RIGID BODY REFINEMENT OF THE 6 SUBUNITS;
 - 200 STEPS OF ENERGY MINIMIZATION WITH
   NON-CRYSTALLOGRAPHIC SYMMETRY CONSTRAINTS (NCSC);
 - 1 PS MD SIMULATION AT 2000 K WITH NCSC;
 - COOLING FROM 2000 TO 300 K IN 1.7 PS WITH NCSC;
 - 44 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - 20 STEPS OF B-FACTOR REFINEMENT WITH NCSC;
R-FACTOR = 21.5 % FOR ALL DATA TO 3.2 A.
MODEL REBUILT INTO THE ONCE AVERAGED (7.0-3.2 A) 2MFO-DFC
MAP (SUBUNIT "R" ONLY)

ROUND 2, WITH THE SECOND LAUE DATA SET
 - RIGID BODY REFINEMENT OF THE 6 SUBUNITS;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - SLOW COOLING FROM 4000 K TO 300 K WITH NCSC;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - 20 STEPS OF B-FACTOR REFINEMENT WITH NCSC;
R-FACTOR = 20.8% BETWEEN 7.0 AND 3.2 A RESOLUTION
MODEL REBUILT USING BOTH UNAVERAGED AND AVERAGED 7.0-3.2 A
2MFO-DFC MAPS (SUBUNIT "R" ONLY)

ROUND 3, WITH THE SECOND LAUE DATA SET
 - RIGID BODY REFINEMENT OF THE 6 SUBUNITS;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - SLOW COOLING FROM 4000 K TO 300 K WITH NCSC;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - 20 STEPS OF B-FACTOR REFINEMENT WITH NCSC;
R-FACTOR = 19.4% BETWEEN 7.0 AND 3.2 A RESOLUTION
MODEL REBUILT USING BOTH AVERAGED AND UNAVERAGED 7.0-3.2 A
2MFO-DFC MAPS

ROUND 4, WITH THE SECOND LAUE DATA SET
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - SLOW COOLING FROM 4000 K TO 475 K WITH NCSC;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - 20 STEPS OF B-FACTOR REFINEMENT WITH NCSC;
R-FACTOR = 19.3% BETWEEN 7.0 AND 3.2 A RESOLUTION
MODEL REBUILT USING AVERAGED AND UNAVERAGED 2MFO-DFC MAPS,
AND THE MAP OBTAINED AT COMPLETION OF THE CYCLIC AVERAGING
PROCEDURE.

ROUND 5, WITH THE SECOND LAUE DATA SET
 - RIGID BODY REFINEMENT OF THE 6 SUBUNITS;
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSC;
 - SLOW COOLING FROM 4000 K TO 1550 K WITH
   NON-CRYSTALLOGRAPHIC SYMMETRY RESTRAINTS (NCSR);
 - 120 STEPS OF ENERGY MINIMIZATION WITH NCSR;
 - 18 STEPS OF B-FACTOR REFINEMENT WITH NCSR;
R-FACTOR=17.6% BETWEEN 7.0 AND 3.2 A RESOLUTION.

RMS DEVIATIONS FROM IDEAL GEOMETRY OF THE REFINED MODEL:
  BOND LENGTHS:             0.020 ANGSTROM
  BOND ANGLES:              3.579 DEGREES
  TORSION ANGLES:          25.506 DEGREES
  TRIGONAL NON-PLANARITY:   0.006 ANGSTROM
  NON-PLANARITY:            0.028 ANGSTROM
  NON-BONDED INTERACTIONS:  0.028 ANGSTROM
;
10 
;
THERE ARE SIX IDENTICAL CHAINS IN THE ASYMMETRIC UNIT.
CHAINS O, P, Q, AND R FORM A TETRAMER IN A GENERAL POSITION
AND CHAINS A AND B FORM A HALF TETRAMER IN A SPECIAL
POSITION, WITH ITS MOLECULAR Q AXIS COINCIDENT WITH THE
CRYSTALLOGRAPHIC Z AXIS.

THE SIX IDENTICAL CHAINS PRESENT IN THE ASYMMETRIC UNIT
HAVE BEEN NUMBERED AS FOLLOWS:
SUBUNIT O (GENERAL TETRAMER) RESIDUES    1 -  361
SUBUNIT P (GENERAL TETRAMER) RESIDUES    1 -  361
SUBUNIT Q (GENERAL TETRAMER) RESIDUES    1 -  361
SUBUNIT R (GENERAL TETRAMER) RESIDUES    1 -  361
SUBUNIT A (HALF TETRAMER)   RESIDUES     1 -  361
SUBUNIT B (HALF TETRAMER)   RESIDUES     1 -  361

THE TRANSFORMATION PRESENTED AS *MTRIX 1* BELOW WILL YIELD
APPROXIMATE COORDINATES FOR CHAIN *O* WHEN APPLIED TO CHAIN
*R*.  THE TRANSFORMATION PRESENTED AS *MTRIX 2* BELOW WILL
YIELD APPROXIMATE COORDINATES FOR CHAIN *P* WHEN APPLIED TO
CHAIN *R*.  THE TRANSFORMATION PRESENTED AS *MTRIX 3* BELOW
WILL YIELD APPROXIMATE COORDINATES FOR CHAIN *Q* WHEN
APPLIED TO CHAIN *R*.  THE TRANSFORMATION PRESENTED AS
*MTRIX 4* BELOW WILL YIELD APPROXIMATE COORDINATES FOR
CHAIN A* WHEN APPLIED TO CHAIN *R*.  THE TRANSFORMATION
PRESENTED AS *MTRIX 5* BELOW WILL YIELD APPROXIMATE
COORDINATES FOR CHAIN *B* WHEN APPLIED TO CHAIN *R*.
;
11 
;
ACCURACY OF THE STRUCTURE.
THE RESOLUTION IS ONLY 3.2 ANGSTROMS.  THE ESTIMATED RMS
COORDINATE ERROR IS 0.37 ANGSTROM. AT THIS LIMITED
RESOLUTION AND WITH THE LIMITED COMPLETENESS OF THE DATA,
NO WATER MOLECULES WERE INTRODUCED IN THE MODEL.
THERE ARE A FEW AREAS OF THE MOLECULE WHICH ARE UNCERTAIN,
AS CAN BE JUDGED FROM THE HIGH TEMPERATURE FACTOR VALUES.
IN PARTICULAR, NO ELECTRON DENSITY IS SEEN FOR THE
C-TERMINAL FINAL TWO RESIDUES, WHICH FOLLOW HELIX ALPHA 3.

THE SULFATE IONS ALSO HAVE LARGE TEMPERATURE FACTOR
VALUES.  HOWEVER, ELECTRON DENSITY HAS ALWAYS BEEN
OBSERVED FOR THESE IONS IN LOCATIONS WHICH ARE SIMILAR
TO THOSE FOR THE SULFATE IONS IN BOTH LOBSTER AND
BACILLUS STEAROTHERMOPHILUS GAPDHASES. THE IONS HAVE
THEREFORE BEEN INCLUDED IN THE MODEL.

ALSO, THERE ARE TWO POSSIBILITIES FOR THE CONFORMATION OF
THE TWO N-TERMINAL RESIDUES. ONE IS AS GIVEN IN THE MODEL,
AND THE ALTERNATIVE PLACES THE N-TERMINAL THREONINE AT THE
LOCATION OCCUPIED BY THE SIDE CHAIN OF ISOLEUCINE 2 AND
VICE-VERSA. THE LIMITED RESOLUTION DOES NOT ALLOW ONE TO
CHOOSE BETWEEN THESE TWO POSSIBILITIES. HOWEVER, THE
CONFORMATION GIVEN IN THE PRESENT MODEL GIVES A HIGHER
NUMBER OF INTERACTIONS INVOLVING THE THREONINE SIDE CHAIN.

ANOTHER UNCERTAINTY CONCERNS THE CELL PARAMETERS:
INITIAL VALUES FOR A, B AND C WERE DERIVED FROM
OSCILLATION PHOTOGRAPHS TAKEN AT THE SRS (SEE REFERENCE 1
ABOVE). HOWEVER, THE LAUE METHOD USED AFTERWARDS FOR DATA
COLLECTION DOES NOT ALLOW TO DERIVE EXACT VALUES FOR THE
CELL AXES, ONLY THE RELATIVE VALUE OF A : B : C IS CORRECT.
HENCE, FOR THE REFINEMENT OF CELL PARAMETER VALUES, THE
SHORTEST CELL AXIS (C = 114.91 A) WAS ASSUMED TO BE KNOWN
WITH THE HIGHEST ACCURACY FROM THE OSCILLATION MEASUREMENTS
AND WAS KEPT CONSTANT DURING CELL PARAMETER REFINEMENT.
THE LACK OF STRONGLY DIFFRACTING GAPDH CRYSTALS HAS SO
FAR PREVENTED US TO DETERMINE ACCURATE CELL PARAMETER
VALUES USING MONOCHROMATIC X-RAY RADIATION.
;
12 
;
THE AMINO ACID SEQUENCE USED IS BASED ON THE GENE SEQUENCE
(SEE REFERENCE 2 ABOVE).
;
13 
;THE FOLLOWING CARDS GIVE THE NON-CRYSTALLOGRAPHIC SYMMETRY
OPERATORS WHICH TRANSFORM SUBUNIT R INTO THE OTHER FIVE
SUBUNITS (O, P, 1, A, B) OF THE ASYMMETRIC UNIT.  THESE
FIVE SYMMETRY OPERATORS WERE USED FOR THE INITIAL ENERGY
MINIMIZATION STEPS WITH NCSC DURING ROUND 5 OF THE
REFINEMENT PROCEDURE.

PROPER SYMMETRY EXISTS WITHIN THE GENERAL TETRAMER
(SUBUNITS O, P, Q, R) AND WITHIN THE SPECIAL HALF TETRAMER
(SUBUNITS A, B).  HOWEVER, THE PRESENCE OF THESE TWO TYPES
OF SYMMETRY WITHIN THE ASYMMETRIC UNIT IS EQUIVALENT TO
IMPROPER SYMMETRY:  THE APPLICATION OF OPERATION NUMBER 4
TO SUBUNIT R TRANSFORMS TO SUBUNIT A, BUT THE APPLICATION
OF THE SAME OPERATION TO SUBUNIT A WILL NOT TRANSFORM BACK
TO SUBUNIT R.
;
14 
;SHEETS 1, 3, 5, 7, 9 AND 11 STRANDS ARE IDENTIFIED BY THE
DEPOSITOR AS FOLLOWS:

     DEPOSITOR     SHEETS 1, 3,
     BETA          5, 7, 9, 11
     STRAND        STRAND
         A            5
         B            4
         C"           1
         C'           2
         C            3
         D            6
         E            7
         F            8
         F'           9
;
15 
;
SHEETS 2, 4, 6, 8, 10 AND 12 STRANDS ARE IDENTIFIED BY THE
DEPOSITOR AS FOLLOWS:

    DEPOSITOR     SHEETS 2, 4,
    BETA          6, 8, 10, 12
    STRAND        STRAND
        1            5
        2            7
        3            6
        4            4
        5            1
        6            2
        8            3
;
# 
loop_
_database_PDB_rev.num 
_database_PDB_rev.date 
_database_PDB_rev.date_original 
_database_PDB_rev.status 
_database_PDB_rev.replaces 
_database_PDB_rev.mod_type 
1 1994-01-31 1991-10-11 ? 1GGA 0 
2 2003-04-01 ?          ? 1GGA 1 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_diffrn_protocol             ? 
# 
_exptl.entry_id          1GGA 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   ? 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      ? 
_exptl_crystal.density_percent_sol   ? 
_exptl_crystal.description           ? 
# 
_refine.entry_id                               1GGA 
_refine.ls_number_reflns_obs                   ? 
_refine.ls_number_reflns_all                   ? 
_refine.pdbx_ls_sigma_I                        ? 
_refine.pdbx_ls_sigma_F                        ? 
_refine.pdbx_data_cutoff_high_absF             ? 
_refine.pdbx_data_cutoff_low_absF              ? 
_refine.pdbx_data_cutoff_high_rms_absF         ? 
_refine.ls_d_res_low                           ? 
_refine.ls_d_res_high                          3.2 
_refine.ls_percent_reflns_obs                  ? 
_refine.ls_R_factor_obs                        0.176 
_refine.ls_R_factor_all                        ? 
_refine.ls_R_factor_R_work                     0.176 
_refine.ls_R_factor_R_free                     ? 
_refine.ls_R_factor_R_free_error               ? 
_refine.ls_R_factor_R_free_error_details       ? 
_refine.ls_percent_reflns_R_free               ? 
_refine.ls_number_reflns_R_free                ? 
_refine.ls_number_parameters                   ? 
_refine.ls_number_restraints                   ? 
_refine.occupancy_min                          ? 
_refine.occupancy_max                          ? 
_refine.B_iso_mean                             ? 
_refine.aniso_B[1][1]                          ? 
_refine.aniso_B[2][2]                          ? 
_refine.aniso_B[3][3]                          ? 
_refine.aniso_B[1][2]                          ? 
_refine.aniso_B[1][3]                          ? 
_refine.aniso_B[2][3]                          ? 
_refine.solvent_model_details                  ? 
_refine.solvent_model_param_ksol               ? 
_refine.solvent_model_param_bsol               ? 
_refine.pdbx_ls_cross_valid_method             ? 
_refine.details                                ? 
_refine.pdbx_starting_model                    ? 
_refine.pdbx_method_to_determine_struct        ? 
_refine.pdbx_isotropic_thermal_model           ? 
_refine.pdbx_stereochemistry_target_values     ? 
_refine.pdbx_stereochem_target_val_spec_case   ? 
_refine.pdbx_R_Free_selection_details          ? 
_refine.pdbx_overall_ESU_R_Free                ? 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
x_bond_d                0.020 ? ? ? 
x_bond_d_na             ?     ? ? ? 
x_bond_d_prot           ?     ? ? ? 
x_angle_d               ?     ? ? ? 
x_angle_d_na            ?     ? ? ? 
x_angle_d_prot          ?     ? ? ? 
x_angle_deg             3.579 ? ? ? 
x_angle_deg_na          ?     ? ? ? 
x_angle_deg_prot        ?     ? ? ? 
x_dihedral_angle_d      ?     ? ? ? 
x_dihedral_angle_d_na   ?     ? ? ? 
x_dihedral_angle_d_prot ?     ? ? ? 
x_improper_angle_d      ?     ? ? ? 
x_improper_angle_d_na   ?     ? ? ? 
x_improper_angle_d_prot ?     ? ? ? 
x_mcbond_it             ?     ? ? ? 
x_mcangle_it            ?     ? ? ? 
x_scbond_it             ?     ? ? ? 
x_scangle_it            ?     ? ? ? 
# 
_struct_keywords.entry_id        1GGA 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE(ALDEHYDE(D)-NAD+(A)) 
_struct_keywords.text            OXIDOREDUCTASE(ALDEHYDE(D)-NAD+(A)) 
# 
_symmetry.entry_id                         1GGA 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                ? 
# 
_entry.id   1GGA 
# 
loop_
_struct_biol.id 
1 
2 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           ? 
_diffrn.ambient_temp_details   ? 
_diffrn.crystal_id             1 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    SWS 
_struct_ref.db_code                    G3PG_TRYBB 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_db_accession          P22512 
_struct_ref.pdbx_align_begin           1 
_struct_ref.pdbx_seq_one_letter_code   
;TIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKH
SVSTTKSKPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAE
GHLRGGARKVVISAPASGGAKTFVMGVNHNNYNPREQHVVSNASCTTNCLAPLVHVLVKE
GFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQG
KLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADF
ISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL

;
_struct_ref.biol_id                    . 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 1GGA O 1 ? 358 ? P22512 1 ? 358 ? 1 358 
2 1 1GGA P 1 ? 358 ? P22512 1 ? 358 ? 1 358 
3 1 1GGA Q 1 ? 358 ? P22512 1 ? 358 ? 1 358 
4 1 1GGA R 1 ? 358 ? P22512 1 ? 358 ? 1 358 
5 1 1GGA A 1 ? 358 ? P22512 1 ? 358 ? 1 358 
6 1 1GGA B 1 ? 358 ? P22512 1 ? 358 ? 1 358 
# 
loop_
_pdbx_entity_name.entity_id 
_pdbx_entity_name.name 
_pdbx_entity_name.name_type 
1 'D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE'           RCSB_NAME   
1 'GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, GLYCOSOMAL' SWS-NAME    
1 'EC 1.2.1.12'                                          SWS-SYNONYM 
1 GAPDH                                                  SWS-SYNONYM 
1 3D-structure                                           SWS-KEYWORD 
1 Glycolysis                                             SWS-KEYWORD 
1 Glycosome                                              SWS-KEYWORD 
1 'Multigene family'                                     SWS-KEYWORD 
1 NAD                                                    SWS-KEYWORD 
1 Oxidoreductase                                         SWS-KEYWORD 
# 
_database_PDB_rev_record.rev_num   2 
_database_PDB_rev_record.type      JRNL 
_database_PDB_rev_record.details   ? 
# 
_atom_sites.entry_id                    1GGA 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007379 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.003902 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008702 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_citation.id 
_citation.title 
_citation.journal_abbrev 
_citation.journal_volume 
_citation.page_first 
_citation.page_last 
_citation.year 
_citation.journal_id_ASTM 
_citation.country 
_citation.journal_id_ISSN 
_citation.journal_id_CSD 
_citation.book_publisher 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_DOI 
primary 
;Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data.
;
Proc.Natl.Acad.Sci.USA 90  2355 2359 1993 PNASA6 US 0027-8424 0040 ? 8460146 ? 
1       
;Preliminary Crystallographic Studies of Glycosomal Glyceraldehyde Phosphate Dehydrogenase from Trypanosoma Brucei
;
J.Mol.Biol.            194 573  ?    1987 JMOBAK UK 0022-2836 0070 ? ?       ? 
2       
;Two Tandemly Linked Identical Genes Code for the Glycosomal Glyceraldehyde-Phosphate Dehydrogenase in Trypanosoma Brucei
;
'Embo J.'              5   1049 ?    1986 EMJODG UK 0261-4189 897  ? ?       ? 
# 
_computing.entry_id                           1GGA 
_computing.data_collection                    ? 
_computing.data_reduction                     ? 
_computing.structure_solution                 X-PLOR 
_computing.structure_refinement               X-PLOR 
_computing.pdbx_structure_refinement_method   ? 
# 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB  1GGA 
NDB  1GGA 
RCSB 1GGA 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.details 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.pdbx_ec 
1 polymer     man 'D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE' 38970.852 6  ? 
? ? 1.2.1.12 
2 non-polymer syn 'SULFATE ION'                                96.058    12 ? 
? ? ?        
3 non-polymer syn NICOTINAMIDE-ADENINE-DINUCLEOTIDE            663.430   6  ? 
? ? ?        
# 
loop_
_entity_keywords.entity_id 
_entity_keywords.text 
1 ? 
2 ? 
3 ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
1 1   THR 
1 2   ILE 
1 3   LYS 
1 4   VAL 
1 5   GLY 
1 6   ILE 
1 7   ASN 
1 8   GLY 
1 9   PHE 
1 10  GLY 
1 11  ARG 
1 12  ILE 
1 13  GLY 
1 14  ARG 
1 15  MET 
1 16  VAL 
1 17  PHE 
1 18  GLN 
1 19  ALA 
1 20  LEU 
1 21  CYS 
1 22  ASP 
1 23  ASP 
1 24  GLY 
1 25  LEU 
1 26  LEU 
1 27  GLY 
1 28  ASN 
1 29  GLU 
1 30  ILE 
1 31  ASP 
1 32  VAL 
1 33  VAL 
1 34  ALA 
1 35  VAL 
1 36  VAL 
1 37  ASP 
1 38  MET 
1 39  ASN 
1 40  THR 
1 41  ASP 
1 42  ALA 
1 43  ARG 
1 44  TYR 
1 45  PHE 
1 46  ALA 
1 47  TYR 
1 48  GLN 
1 49  MET 
1 50  LYS 
1 51  TYR 
1 52  ASP 
1 53  SER 
1 54  VAL 
1 55  HIS 
1 56  GLY 
1 57  LYS 
1 58  PHE 
1 59  LYS 
1 60  HIS 
1 61  SER 
1 62  VAL 
1 63  SER 
1 64  THR 
1 65  THR 
1 66  LYS 
1 67  SER 
1 68  LYS 
1 69  PRO 
1 70  SER 
1 71  VAL 
1 72  ALA 
1 73  LYS 
1 74  ASP 
1 75  ASP 
1 76  THR 
1 77  LEU 
1 78  VAL 
1 79  VAL 
1 80  ASN 
1 81  GLY 
1 82  HIS 
1 83  ARG 
1 84  ILE 
1 85  LEU 
1 86  CYS 
1 87  VAL 
1 88  LYS 
1 89  ALA 
1 90  GLN 
1 91  ARG 
1 92  ASN 
1 93  PRO 
1 94  ALA 
1 95  ASP 
1 96  LEU 
1 97  PRO 
1 98  TRP 
1 99  GLY 
1 100 LYS 
1 101 LEU 
1 102 GLY 
1 103 VAL 
1 104 GLU 
1 105 TYR 
1 106 VAL 
1 107 ILE 
1 108 GLU 
1 109 SER 
1 110 THR 
1 111 GLY 
1 112 LEU 
1 113 PHE 
1 114 THR 
1 115 VAL 
1 116 LYS 
1 117 SER 
1 118 ALA 
1 119 ALA 
1 120 GLU 
1 121 GLY 
1 122 HIS 
1 123 LEU 
1 124 ARG 
1 125 GLY 
1 126 GLY 
1 127 ALA 
1 128 ARG 
1 129 LYS 
1 130 VAL 
1 131 VAL 
1 132 ILE 
1 133 SER 
1 134 ALA 
1 135 PRO 
1 136 ALA 
1 137 SER 
1 138 GLY 
1 139 GLY 
1 140 ALA 
1 141 LYS 
1 142 THR 
1 143 PHE 
1 144 VAL 
1 145 MET 
1 146 GLY 
1 147 VAL 
1 148 ASN 
1 149 HIS 
1 150 ASN 
1 151 ASN 
1 152 TYR 
1 153 ASN 
1 154 PRO 
1 155 ARG 
1 156 GLU 
1 157 GLN 
1 158 HIS 
1 159 VAL 
1 160 VAL 
1 161 SER 
1 162 ASN 
1 163 ALA 
1 164 SER 
1 165 CYS 
1 166 THR 
1 167 THR 
1 168 ASN 
1 169 CYS 
1 170 LEU 
1 171 ALA 
1 172 PRO 
1 173 LEU 
1 174 VAL 
1 175 HIS 
1 176 VAL 
1 177 LEU 
1 178 VAL 
1 179 LYS 
1 180 GLU 
1 181 GLY 
1 182 PHE 
1 183 GLY 
1 184 ILE 
1 185 SER 
1 186 THR 
1 187 GLY 
1 188 LEU 
1 189 MET 
1 190 THR 
1 191 THR 
1 192 VAL 
1 193 HIS 
1 194 SER 
1 195 TYR 
1 196 THR 
1 197 ALA 
1 198 THR 
1 199 GLN 
1 200 LYS 
1 201 THR 
1 202 VAL 
1 203 ASP 
1 204 GLY 
1 205 VAL 
1 206 SER 
1 207 VAL 
1 208 LYS 
1 209 ASP 
1 210 TRP 
1 211 ARG 
1 212 GLY 
1 213 GLY 
1 214 ARG 
1 215 ALA 
1 216 ALA 
1 217 ALA 
1 218 LEU 
1 219 ASN 
1 220 ILE 
1 221 ILE 
1 222 PRO 
1 223 SER 
1 224 THR 
1 225 THR 
1 226 GLY 
1 227 ALA 
1 228 ALA 
1 229 LYS 
1 230 ALA 
1 231 VAL 
1 232 GLY 
1 233 MET 
1 234 VAL 
1 235 ILE 
1 236 PRO 
1 237 SER 
1 238 THR 
1 239 GLN 
1 240 GLY 
1 241 LYS 
1 242 LEU 
1 243 THR 
1 244 GLY 
1 245 MET 
1 246 ALA 
1 247 PHE 
1 248 ARG 
1 249 VAL 
1 250 PRO 
1 251 THR 
1 252 ALA 
1 253 ASP 
1 254 VAL 
1 255 SER 
1 256 VAL 
1 257 VAL 
1 258 ASP 
1 259 LEU 
1 260 THR 
1 261 PHE 
1 262 ILE 
1 263 ALA 
1 264 THR 
1 265 ARG 
1 266 ASP 
1 267 THR 
1 268 SER 
1 269 ILE 
1 270 LYS 
1 271 GLU 
1 272 ILE 
1 273 ASP 
1 274 ALA 
1 275 ALA 
1 276 LEU 
1 277 LYS 
1 278 ARG 
1 279 ALA 
1 280 SER 
1 281 LYS 
1 282 THR 
1 283 TYR 
1 284 MET 
1 285 LYS 
1 286 ASN 
1 287 ILE 
1 288 LEU 
1 289 GLY 
1 290 TYR 
1 291 THR 
1 292 ASP 
1 293 GLU 
1 294 GLU 
1 295 LEU 
1 296 VAL 
1 297 SER 
1 298 ALA 
1 299 ASP 
1 300 PHE 
1 301 ILE 
1 302 SER 
1 303 ASP 
1 304 SER 
1 305 ARG 
1 306 SER 
1 307 SER 
1 308 ILE 
1 309 TYR 
1 310 ASP 
1 311 SER 
1 312 LYS 
1 313 ALA 
1 314 THR 
1 315 LEU 
1 316 GLN 
1 317 ASN 
1 318 ASN 
1 319 LEU 
1 320 PRO 
1 321 ASN 
1 322 GLU 
1 323 ARG 
1 324 ARG 
1 325 PHE 
1 326 PHE 
1 327 LYS 
1 328 ILE 
1 329 VAL 
1 330 SER 
1 331 TRP 
1 332 TYR 
1 333 ASP 
1 334 ASN 
1 335 GLU 
1 336 TRP 
1 337 GLY 
1 338 TYR 
1 339 SER 
1 340 HIS 
1 341 ARG 
1 342 VAL 
1 343 VAL 
1 344 ASP 
1 345 LEU 
1 346 VAL 
1 347 ARG 
1 348 HIS 
1 349 MET 
1 350 ALA 
1 351 ALA 
1 352 ARG 
1 353 ASP 
1 354 ARG 
1 355 ALA 
1 356 ALA 
1 357 LYS 
1 358 LEU 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           polypeptide(L) 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;TIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKHSVSTTKSKPSVAKDDTLVVN
GHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNNYNPREQHVV
SNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQG
KLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLP
NERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;TIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKHSVSTTKSKPSVAKDDTLVVN
GHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNNYNPREQHVV
SNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQG
KLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLP
NERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL
;
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
A 1 1   THR 1   1   1   THR THR O . 
A 1 2   ILE 2   2   2   ILE ILE O . 
A 1 3   LYS 3   3   3   LYS LYS O . 
A 1 4   VAL 4   4   4   VAL VAL O . 
A 1 5   GLY 5   5   5   GLY GLY O . 
A 1 6   ILE 6   6   6   ILE ILE O . 
A 1 7   ASN 7   7   7   ASN ASN O . 
A 1 8   GLY 8   8   8   GLY GLY O . 
A 1 9   PHE 9   9   9   PHE PHE O . 
A 1 10  GLY 10  10  10  GLY GLY O . 
A 1 11  ARG 11  11  11  ARG ARG O . 
A 1 12  ILE 12  12  12  ILE ILE O . 
A 1 13  GLY 13  13  13  GLY GLY O . 
A 1 14  ARG 14  14  14  ARG ARG O . 
A 1 15  MET 15  15  15  MET MET O . 
A 1 16  VAL 16  16  16  VAL VAL O . 
A 1 17  PHE 17  17  17  PHE PHE O . 
A 1 18  GLN 18  18  18  GLN GLN O . 
A 1 19  ALA 19  19  19  ALA ALA O . 
A 1 20  LEU 20  20  20  LEU LEU O . 
A 1 21  CYS 21  21  21  CYS CYS O . 
A 1 22  ASP 22  22  22  ASP ASP O . 
A 1 23  ASP 23  23  23  ASP ASP O . 
A 1 24  GLY 24  24  24  GLY GLY O . 
A 1 25  LEU 25  25  25  LEU LEU O . 
A 1 26  LEU 26  26  26  LEU LEU O . 
A 1 27  GLY 27  27  27  GLY GLY O . 
A 1 28  ASN 28  28  28  ASN ASN O . 
A 1 29  GLU 29  29  29  GLU GLU O . 
A 1 30  ILE 30  30  30  ILE ILE O . 
A 1 31  ASP 31  31  31  ASP ASP O . 
A 1 32  VAL 32  32  32  VAL VAL O . 
A 1 33  VAL 33  33  33  VAL VAL O . 
A 1 34  ALA 34  34  34  ALA ALA O . 
A 1 35  VAL 35  35  35  VAL VAL O . 
A 1 36  VAL 36  36  36  VAL VAL O . 
A 1 37  ASP 37  37  37  ASP ASP O . 
A 1 38  MET 38  38  38  MET MET O . 
A 1 39  ASN 39  39  39  ASN ASN O . 
A 1 40  THR 40  40  40  THR THR O . 
A 1 41  ASP 41  41  41  ASP ASP O . 
A 1 42  ALA 42  42  42  ALA ALA O . 
A 1 43  ARG 43  43  43  ARG ARG O . 
A 1 44  TYR 44  44  44  TYR TYR O . 
A 1 45  PHE 45  45  45  PHE PHE O . 
A 1 46  ALA 46  46  46  ALA ALA O . 
A 1 47  TYR 47  47  47  TYR TYR O . 
A 1 48  GLN 48  48  48  GLN GLN O . 
A 1 49  MET 49  49  49  MET MET O . 
A 1 50  LYS 50  50  50  LYS LYS O . 
A 1 51  TYR 51  51  51  TYR TYR O . 
A 1 52  ASP 52  52  52  ASP ASP O . 
A 1 53  SER 53  53  53  SER SER O . 
A 1 54  VAL 54  54  54  VAL VAL O . 
A 1 55  HIS 55  55  55  HIS HIS O . 
A 1 56  GLY 56  56  56  GLY GLY O . 
A 1 57  LYS 57  57  57  LYS LYS O . 
A 1 58  PHE 58  58  58  PHE PHE O . 
A 1 59  LYS 59  59  59  LYS LYS O . 
A 1 60  HIS 60  60  60  HIS HIS O . 
A 1 61  SER 61  61  61  SER SER O . 
A 1 62  VAL 62  62  62  VAL VAL O . 
A 1 63  SER 63  63  63  SER SER O . 
A 1 64  THR 64  64  64  THR THR O . 
A 1 65  THR 65  65  65  THR THR O . 
A 1 66  LYS 66  66  66  LYS LYS O . 
A 1 67  SER 67  67  67  SER SER O . 
A 1 68  LYS 68  68  68  LYS LYS O . 
A 1 69  PRO 69  69  69  PRO PRO O . 
A 1 70  SER 70  70  70  SER SER O . 
A 1 71  VAL 71  71  71  VAL VAL O . 
A 1 72  ALA 72  72  72  ALA ALA O . 
A 1 73  LYS 73  73  73  LYS LYS O . 
A 1 74  ASP 74  74  74  ASP ASP O . 
A 1 75  ASP 75  75  75  ASP ASP O . 
A 1 76  THR 76  76  76  THR THR O . 
A 1 77  LEU 77  77  77  LEU LEU O . 
A 1 78  VAL 78  78  78  VAL VAL O . 
A 1 79  VAL 79  79  79  VAL VAL O . 
A 1 80  ASN 80  80  80  ASN ASN O . 
A 1 81  GLY 81  81  81  GLY GLY O . 
A 1 82  HIS 82  82  82  HIS HIS O . 
A 1 83  ARG 83  83  83  ARG ARG O . 
A 1 84  ILE 84  84  84  ILE ILE O . 
A 1 85  LEU 85  85  85  LEU LEU O . 
A 1 86  CYS 86  86  86  CYS CYS O . 
A 1 87  VAL 87  87  87  VAL VAL O . 
A 1 88  LYS 88  88  88  LYS LYS O . 
A 1 89  ALA 89  89  89  ALA ALA O . 
A 1 90  GLN 90  90  90  GLN GLN O . 
A 1 91  ARG 91  91  91  ARG ARG O . 
A 1 92  ASN 92  92  92  ASN ASN O . 
A 1 93  PRO 93  93  93  PRO PRO O . 
A 1 94  ALA 94  94  94  ALA ALA O . 
A 1 95  ASP 95  95  95  ASP ASP O . 
A 1 96  LEU 96  96  96  LEU LEU O . 
A 1 97  PRO 97  97  97  PRO PRO O . 
A 1 98  TRP 98  98  98  TRP TRP O . 
A 1 99  GLY 99  99  99  GLY GLY O . 
A 1 100 LYS 100 100 100 LYS LYS O . 
A 1 101 LEU 101 101 101 LEU LEU O . 
A 1 102 GLY 102 102 102 GLY GLY O . 
A 1 103 VAL 103 103 103 VAL VAL O . 
A 1 104 GLU 104 104 104 GLU GLU O . 
A 1 105 TYR 105 105 105 TYR TYR O . 
A 1 106 VAL 106 106 106 VAL VAL O . 
A 1 107 ILE 107 107 107 ILE ILE O . 
A 1 108 GLU 108 108 108 GLU GLU O . 
A 1 109 SER 109 109 109 SER SER O . 
A 1 110 THR 110 110 110 THR THR O . 
A 1 111 GLY 111 111 111 GLY GLY O . 
A 1 112 LEU 112 112 112 LEU LEU O . 
A 1 113 PHE 113 113 113 PHE PHE O . 
A 1 114 THR 114 114 114 THR THR O . 
A 1 115 VAL 115 115 115 VAL VAL O . 
A 1 116 LYS 116 116 116 LYS LYS O . 
A 1 117 SER 117 117 117 SER SER O . 
A 1 118 ALA 118 118 118 ALA ALA O . 
A 1 119 ALA 119 119 119 ALA ALA O . 
A 1 120 GLU 120 120 120 GLU GLU O . 
A 1 121 GLY 121 121 121 GLY GLY O . 
A 1 122 HIS 122 122 122 HIS HIS O . 
A 1 123 LEU 123 123 123 LEU LEU O . 
A 1 124 ARG 124 124 124 ARG ARG O . 
A 1 125 GLY 125 125 125 GLY GLY O . 
A 1 126 GLY 126 126 126 GLY GLY O . 
A 1 127 ALA 127 127 127 ALA ALA O . 
A 1 128 ARG 128 128 128 ARG ARG O . 
A 1 129 LYS 129 129 129 LYS LYS O . 
A 1 130 VAL 130 130 130 VAL VAL O . 
A 1 131 VAL 131 131 131 VAL VAL O . 
A 1 132 ILE 132 132 132 ILE ILE O . 
A 1 133 SER 133 133 133 SER SER O . 
A 1 134 ALA 134 134 134 ALA ALA O . 
A 1 135 PRO 135 135 135 PRO PRO O . 
A 1 136 ALA 136 136 136 ALA ALA O . 
A 1 137 SER 137 137 137 SER SER O . 
A 1 138 GLY 138 138 138 GLY GLY O . 
A 1 139 GLY 139 139 139 GLY GLY O . 
A 1 140 ALA 140 140 140 ALA ALA O . 
A 1 141 LYS 141 141 141 LYS LYS O . 
A 1 142 THR 142 142 142 THR THR O . 
A 1 143 PHE 143 143 143 PHE PHE O . 
A 1 144 VAL 144 144 144 VAL VAL O . 
A 1 145 MET 145 145 145 MET MET O . 
A 1 146 GLY 146 146 146 GLY GLY O . 
A 1 147 VAL 147 147 147 VAL VAL O . 
A 1 148 ASN 148 148 148 ASN ASN O . 
A 1 149 HIS 149 149 149 HIS HIS O . 
A 1 150 ASN 150 150 150 ASN ASN O . 
A 1 151 ASN 151 151 151 ASN ASN O . 
A 1 152 TYR 152 152 152 TYR TYR O . 
A 1 153 ASN 153 153 153 ASN ASN O . 
A 1 154 PRO 154 154 154 PRO PRO O . 
A 1 155 ARG 155 155 155 ARG ARG O . 
A 1 156 GLU 156 156 156 GLU GLU O . 
A 1 157 GLN 157 157 157 GLN GLN O . 
A 1 158 HIS 158 158 158 HIS HIS O . 
A 1 159 VAL 159 159 159 VAL VAL O . 
A 1 160 VAL 160 160 160 VAL VAL O . 
A 1 161 SER 161 161 161 SER SER O . 
A 1 162 ASN 162 162 162 ASN ASN O . 
A 1 163 ALA 163 163 163 ALA ALA O . 
A 1 164 SER 164 164 164 SER SER O . 
A 1 165 CYS 165 165 165 CYS CYS O . 
A 1 166 THR 166 166 166 THR THR O . 
A 1 167 THR 167 167 167 THR THR O . 
A 1 168 ASN 168 168 168 ASN ASN O . 
A 1 169 CYS 169 169 169 CYS CYS O . 
A 1 170 LEU 170 170 170 LEU LEU O . 
A 1 171 ALA 171 171 171 ALA ALA O . 
A 1 172 PRO 172 172 172 PRO PRO O . 
A 1 173 LEU 173 173 173 LEU LEU O . 
A 1 174 VAL 174 174 174 VAL VAL O . 
A 1 175 HIS 175 175 175 HIS HIS O . 
A 1 176 VAL 176 176 176 VAL VAL O . 
A 1 177 LEU 177 177 177 LEU LEU O . 
A 1 178 VAL 178 178 178 VAL VAL O . 
A 1 179 LYS 179 179 179 LYS LYS O . 
A 1 180 GLU 180 180 180 GLU GLU O . 
A 1 181 GLY 181 181 181 GLY GLY O . 
A 1 182 PHE 182 182 182 PHE PHE O . 
A 1 183 GLY 183 183 183 GLY GLY O . 
A 1 184 ILE 184 184 184 ILE ILE O . 
A 1 185 SER 185 185 185 SER SER O . 
A 1 186 THR 186 186 186 THR THR O . 
A 1 187 GLY 187 187 187 GLY GLY O . 
A 1 188 LEU 188 188 188 LEU LEU O . 
A 1 189 MET 189 189 189 MET MET O . 
A 1 190 THR 190 190 190 THR THR O . 
A 1 191 THR 191 191 191 THR THR O . 
A 1 192 VAL 192 192 192 VAL VAL O . 
A 1 193 HIS 193 193 193 HIS HIS O . 
A 1 194 SER 194 194 194 SER SER O . 
A 1 195 TYR 195 195 195 TYR TYR O . 
A 1 196 THR 196 196 196 THR THR O . 
A 1 197 ALA 197 197 197 ALA ALA O . 
A 1 198 THR 198 198 198 THR THR O . 
A 1 199 GLN 199 199 199 GLN GLN O . 
A 1 200 LYS 200 200 200 LYS LYS O . 
A 1 201 THR 201 201 201 THR THR O . 
A 1 202 VAL 202 202 202 VAL VAL O . 
A 1 203 ASP 203 203 203 ASP ASP O . 
A 1 204 GLY 204 204 204 GLY GLY O . 
A 1 205 VAL 205 205 205 VAL VAL O . 
A 1 206 SER 206 206 206 SER SER O . 
A 1 207 VAL 207 207 207 VAL VAL O . 
A 1 208 LYS 208 208 208 LYS LYS O . 
A 1 209 ASP 209 209 209 ASP ASP O . 
A 1 210 TRP 210 210 210 TRP TRP O . 
A 1 211 ARG 211 211 211 ARG ARG O . 
A 1 212 GLY 212 212 212 GLY GLY O . 
A 1 213 GLY 213 213 213 GLY GLY O . 
A 1 214 ARG 214 214 214 ARG ARG O . 
A 1 215 ALA 215 215 215 ALA ALA O . 
A 1 216 ALA 216 216 216 ALA ALA O . 
A 1 217 ALA 217 217 217 ALA ALA O . 
A 1 218 LEU 218 218 218 LEU LEU O . 
A 1 219 ASN 219 219 219 ASN ASN O . 
A 1 220 ILE 220 220 220 ILE ILE O . 
A 1 221 ILE 221 221 221 ILE ILE O . 
A 1 222 PRO 222 222 222 PRO PRO O . 
A 1 223 SER 223 223 223 SER SER O . 
A 1 224 THR 224 224 224 THR THR O . 
A 1 225 THR 225 225 225 THR THR O . 
A 1 226 GLY 226 226 226 GLY GLY O . 
A 1 227 ALA 227 227 227 ALA ALA O . 
A 1 228 ALA 228 228 228 ALA ALA O . 
A 1 229 LYS 229 229 229 LYS LYS O . 
A 1 230 ALA 230 230 230 ALA ALA O . 
A 1 231 VAL 231 231 231 VAL VAL O . 
A 1 232 GLY 232 232 232 GLY GLY O . 
A 1 233 MET 233 233 233 MET MET O . 
A 1 234 VAL 234 234 234 VAL VAL O . 
A 1 235 ILE 235 235 235 ILE ILE O . 
A 1 236 PRO 236 236 236 PRO PRO O . 
A 1 237 SER 237 237 237 SER SER O . 
A 1 238 THR 238 238 238 THR THR O . 
A 1 239 GLN 239 239 239 GLN GLN O . 
A 1 240 GLY 240 240 240 GLY GLY O . 
A 1 241 LYS 241 241 241 LYS LYS O . 
A 1 242 LEU 242 242 242 LEU LEU O . 
A 1 243 THR 243 243 243 THR THR O . 
A 1 244 GLY 244 244 244 GLY GLY O . 
A 1 245 MET 245 245 245 MET MET O . 
A 1 246 ALA 246 246 246 ALA ALA O . 
A 1 247 PHE 247 247 247 PHE PHE O . 
A 1 248 ARG 248 248 248 ARG ARG O . 
A 1 249 VAL 249 249 249 VAL VAL O . 
A 1 250 PRO 250 250 250 PRO PRO O . 
A 1 251 THR 251 251 251 THR THR O . 
A 1 252 ALA 252 252 252 ALA ALA O . 
A 1 253 ASP 253 253 253 ASP ASP O . 
A 1 254 VAL 254 254 254 VAL VAL O . 
A 1 255 SER 255 255 255 SER SER O . 
A 1 256 VAL 256 256 256 VAL VAL O . 
A 1 257 VAL 257 257 257 VAL VAL O . 
A 1 258 ASP 258 258 258 ASP ASP O . 
A 1 259 LEU 259 259 259 LEU LEU O . 
A 1 260 THR 260 260 260 THR THR O . 
A 1 261 PHE 261 261 261 PHE PHE O . 
A 1 262 ILE 262 262 262 ILE ILE O . 
A 1 263 ALA 263 263 263 ALA ALA O . 
A 1 264 THR 264 264 264 THR THR O . 
A 1 265 ARG 265 265 265 ARG ARG O . 
A 1 266 ASP 266 266 266 ASP ASP O . 
A 1 267 THR 267 267 267 THR THR O . 
A 1 268 SER 268 268 268 SER SER O . 
A 1 269 ILE 269 269 269 ILE ILE O . 
A 1 270 LYS 270 270 270 LYS LYS O . 
A 1 271 GLU 271 271 271 GLU GLU O . 
A 1 272 ILE 272 272 272 ILE ILE O . 
A 1 273 ASP 273 273 273 ASP ASP O . 
A 1 274 ALA 274 274 274 ALA ALA O . 
A 1 275 ALA 275 275 275 ALA ALA O . 
A 1 276 LEU 276 276 276 LEU LEU O . 
A 1 277 LYS 277 277 277 LYS LYS O . 
A 1 278 ARG 278 278 278 ARG ARG O . 
A 1 279 ALA 279 279 279 ALA ALA O . 
A 1 280 SER 280 280 280 SER SER O . 
A 1 281 LYS 281 281 281 LYS LYS O . 
A 1 282 THR 282 282 282 THR THR O . 
A 1 283 TYR 283 283 283 TYR TYR O . 
A 1 284 MET 284 284 284 MET MET O . 
A 1 285 LYS 285 285 285 LYS LYS O . 
A 1 286 ASN 286 286 286 ASN ASN O . 
A 1 287 ILE 287 287 287 ILE ILE O . 
A 1 288 LEU 288 288 288 LEU LEU O . 
A 1 289 GLY 289 289 289 GLY GLY O . 
A 1 290 TYR 290 290 290 TYR TYR O . 
A 1 291 THR 291 291 291 THR THR O . 
A 1 292 ASP 292 292 292 ASP ASP O . 
A 1 293 GLU 293 293 293 GLU GLU O . 
A 1 294 GLU 294 294 294 GLU GLU O . 
A 1 295 LEU 295 295 295 LEU LEU O . 
A 1 296 VAL 296 296 296 VAL VAL O . 
A 1 297 SER 297 297 297 SER SER O . 
A 1 298 ALA 298 298 298 ALA ALA O . 
A 1 299 ASP 299 299 299 ASP ASP O . 
A 1 300 PHE 300 300 300 PHE PHE O . 
A 1 301 ILE 301 301 301 ILE ILE O . 
A 1 302 SER 302 302 302 SER SER O . 
A 1 303 ASP 303 303 303 ASP ASP O . 
A 1 304 SER 304 304 304 SER SER O . 
A 1 305 ARG 305 305 305 ARG ARG O . 
A 1 306 SER 306 306 306 SER SER O . 
A 1 307 SER 307 307 307 SER SER O . 
A 1 308 ILE 308 308 308 ILE ILE O . 
A 1 309 TYR 309 309 309 TYR TYR O . 
A 1 310 ASP 310 310 310 ASP ASP O . 
A 1 311 SER 311 311 311 SER SER O . 
A 1 312 LYS 312 312 312 LYS LYS O . 
A 1 313 ALA 313 313 313 ALA ALA O . 
A 1 314 THR 314 314 314 THR THR O . 
A 1 315 LEU 315 315 315 LEU LEU O . 
A 1 316 GLN 316 316 316 GLN GLN O . 
A 1 317 ASN 317 317 317 ASN ASN O . 
A 1 318 ASN 318 318 318 ASN ASN O . 
A 1 319 LEU 319 319 319 LEU LEU O . 
A 1 320 PRO 320 320 320 PRO PRO O . 
A 1 321 ASN 321 321 321 ASN ASN O . 
A 1 322 GLU 322 322 322 GLU GLU O . 
A 1 323 ARG 323 323 323 ARG ARG O . 
A 1 324 ARG 324 324 324 ARG ARG O . 
A 1 325 PHE 325 325 325 PHE PHE O . 
A 1 326 PHE 326 326 326 PHE PHE O . 
A 1 327 LYS 327 327 327 LYS LYS O . 
A 1 328 ILE 328 328 328 ILE ILE O . 
A 1 329 VAL 329 329 329 VAL VAL O . 
A 1 330 SER 330 330 330 SER SER O . 
A 1 331 TRP 331 331 331 TRP TRP O . 
A 1 332 TYR 332 332 332 TYR TYR O . 
A 1 333 ASP 333 333 333 ASP ASP O . 
A 1 334 ASN 334 334 334 ASN ASN O . 
A 1 335 GLU 335 335 335 GLU GLU O . 
A 1 336 TRP 336 336 336 TRP TRP O . 
A 1 337 GLY 337 337 337 GLY GLY O . 
A 1 338 TYR 338 338 338 TYR TYR O . 
A 1 339 SER 339 339 339 SER SER O . 
A 1 340 HIS 340 340 340 HIS HIS O . 
A 1 341 ARG 341 341 341 ARG ARG O . 
A 1 342 VAL 342 342 342 VAL VAL O . 
A 1 343 VAL 343 343 343 VAL VAL O . 
A 1 344 ASP 344 344 344 ASP ASP O . 
A 1 345 LEU 345 345 345 LEU LEU O . 
A 1 346 VAL 346 346 346 VAL VAL O . 
A 1 347 ARG 347 347 347 ARG ARG O . 
A 1 348 HIS 348 348 348 HIS HIS O . 
A 1 349 MET 349 349 349 MET MET O . 
A 1 350 ALA 350 350 350 ALA ALA O . 
A 1 351 ALA 351 351 351 ALA ALA O . 
A 1 352 ARG 352 352 352 ARG ARG O . 
A 1 353 ASP 353 353 353 ASP ASP O . 
A 1 354 ARG 354 354 354 ARG ARG O . 
A 1 355 ALA 355 355 355 ALA ALA O . 
A 1 356 ALA 356 356 356 ALA ALA O . 
A 1 357 LYS 357 357 357 LYS LYS O . 
A 1 358 LEU 358 358 358 LEU LEU O . 
B 1 1   THR 1   1   1   THR THR P . 
B 1 2   ILE 2   2   2   ILE ILE P . 
B 1 3   LYS 3   3   3   LYS LYS P . 
B 1 4   VAL 4   4   4   VAL VAL P . 
B 1 5   GLY 5   5   5   GLY GLY P . 
B 1 6   ILE 6   6   6   ILE ILE P . 
B 1 7   ASN 7   7   7   ASN ASN P . 
B 1 8   GLY 8   8   8   GLY GLY P . 
B 1 9   PHE 9   9   9   PHE PHE P . 
B 1 10  GLY 10  10  10  GLY GLY P . 
B 1 11  ARG 11  11  11  ARG ARG P . 
B 1 12  ILE 12  12  12  ILE ILE P . 
B 1 13  GLY 13  13  13  GLY GLY P . 
B 1 14  ARG 14  14  14  ARG ARG P . 
B 1 15  MET 15  15  15  MET MET P . 
B 1 16  VAL 16  16  16  VAL VAL P . 
B 1 17  PHE 17  17  17  PHE PHE P . 
B 1 18  GLN 18  18  18  GLN GLN P . 
B 1 19  ALA 19  19  19  ALA ALA P . 
B 1 20  LEU 20  20  20  LEU LEU P . 
B 1 21  CYS 21  21  21  CYS CYS P . 
B 1 22  ASP 22  22  22  ASP ASP P . 
B 1 23  ASP 23  23  23  ASP ASP P . 
B 1 24  GLY 24  24  24  GLY GLY P . 
B 1 25  LEU 25  25  25  LEU LEU P . 
B 1 26  LEU 26  26  26  LEU LEU P . 
B 1 27  GLY 27  27  27  GLY GLY P . 
B 1 28  ASN 28  28  28  ASN ASN P . 
B 1 29  GLU 29  29  29  GLU GLU P . 
B 1 30  ILE 30  30  30  ILE ILE P . 
B 1 31  ASP 31  31  31  ASP ASP P . 
B 1 32  VAL 32  32  32  VAL VAL P . 
B 1 33  VAL 33  33  33  VAL VAL P . 
B 1 34  ALA 34  34  34  ALA ALA P . 
B 1 35  VAL 35  35  35  VAL VAL P . 
B 1 36  VAL 36  36  36  VAL VAL P . 
B 1 37  ASP 37  37  37  ASP ASP P . 
B 1 38  MET 38  38  38  MET MET P . 
B 1 39  ASN 39  39  39  ASN ASN P . 
B 1 40  THR 40  40  40  THR THR P . 
B 1 41  ASP 41  41  41  ASP ASP P . 
B 1 42  ALA 42  42  42  ALA ALA P . 
B 1 43  ARG 43  43  43  ARG ARG P . 
B 1 44  TYR 44  44  44  TYR TYR P . 
B 1 45  PHE 45  45  45  PHE PHE P . 
B 1 46  ALA 46  46  46  ALA ALA P . 
B 1 47  TYR 47  47  47  TYR TYR P . 
B 1 48  GLN 48  48  48  GLN GLN P . 
B 1 49  MET 49  49  49  MET MET P . 
B 1 50  LYS 50  50  50  LYS LYS P . 
B 1 51  TYR 51  51  51  TYR TYR P . 
B 1 52  ASP 52  52  52  ASP ASP P . 
B 1 53  SER 53  53  53  SER SER P . 
B 1 54  VAL 54  54  54  VAL VAL P . 
B 1 55  HIS 55  55  55  HIS HIS P . 
B 1 56  GLY 56  56  56  GLY GLY P . 
B 1 57  LYS 57  57  57  LYS LYS P . 
B 1 58  PHE 58  58  58  PHE PHE P . 
B 1 59  LYS 59  59  59  LYS LYS P . 
B 1 60  HIS 60  60  60  HIS HIS P . 
B 1 61  SER 61  61  61  SER SER P . 
B 1 62  VAL 62  62  62  VAL VAL P . 
B 1 63  SER 63  63  63  SER SER P . 
B 1 64  THR 64  64  64  THR THR P . 
B 1 65  THR 65  65  65  THR THR P . 
B 1 66  LYS 66  66  66  LYS LYS P . 
B 1 67  SER 67  67  67  SER SER P . 
B 1 68  LYS 68  68  68  LYS LYS P . 
B 1 69  PRO 69  69  69  PRO PRO P . 
B 1 70  SER 70  70  70  SER SER P . 
B 1 71  VAL 71  71  71  VAL VAL P . 
B 1 72  ALA 72  72  72  ALA ALA P . 
B 1 73  LYS 73  73  73  LYS LYS P . 
B 1 74  ASP 74  74  74  ASP ASP P . 
B 1 75  ASP 75  75  75  ASP ASP P . 
B 1 76  THR 76  76  76  THR THR P . 
B 1 77  LEU 77  77  77  LEU LEU P . 
B 1 78  VAL 78  78  78  VAL VAL P . 
B 1 79  VAL 79  79  79  VAL VAL P . 
B 1 80  ASN 80  80  80  ASN ASN P . 
B 1 81  GLY 81  81  81  GLY GLY P . 
B 1 82  HIS 82  82  82  HIS HIS P . 
B 1 83  ARG 83  83  83  ARG ARG P . 
B 1 84  ILE 84  84  84  ILE ILE P . 
B 1 85  LEU 85  85  85  LEU LEU P . 
B 1 86  CYS 86  86  86  CYS CYS P . 
B 1 87  VAL 87  87  87  VAL VAL P . 
B 1 88  LYS 88  88  88  LYS LYS P . 
B 1 89  ALA 89  89  89  ALA ALA P . 
B 1 90  GLN 90  90  90  GLN GLN P . 
B 1 91  ARG 91  91  91  ARG ARG P . 
B 1 92  ASN 92  92  92  ASN ASN P . 
B 1 93  PRO 93  93  93  PRO PRO P . 
B 1 94  ALA 94  94  94  ALA ALA P . 
B 1 95  ASP 95  95  95  ASP ASP P . 
B 1 96  LEU 96  96  96  LEU LEU P . 
B 1 97  PRO 97  97  97  PRO PRO P . 
B 1 98  TRP 98  98  98  TRP TRP P . 
B 1 99  GLY 99  99  99  GLY GLY P . 
B 1 100 LYS 100 100 100 LYS LYS P . 
B 1 101 LEU 101 101 101 LEU LEU P . 
B 1 102 GLY 102 102 102 GLY GLY P . 
B 1 103 VAL 103 103 103 VAL VAL P . 
B 1 104 GLU 104 104 104 GLU GLU P . 
B 1 105 TYR 105 105 105 TYR TYR P . 
B 1 106 VAL 106 106 106 VAL VAL P . 
B 1 107 ILE 107 107 107 ILE ILE P . 
B 1 108 GLU 108 108 108 GLU GLU P . 
B 1 109 SER 109 109 109 SER SER P . 
B 1 110 THR 110 110 110 THR THR P . 
B 1 111 GLY 111 111 111 GLY GLY P . 
B 1 112 LEU 112 112 112 LEU LEU P . 
B 1 113 PHE 113 113 113 PHE PHE P . 
B 1 114 THR 114 114 114 THR THR P . 
B 1 115 VAL 115 115 115 VAL VAL P . 
B 1 116 LYS 116 116 116 LYS LYS P . 
B 1 117 SER 117 117 117 SER SER P . 
B 1 118 ALA 118 118 118 ALA ALA P . 
B 1 119 ALA 119 119 119 ALA ALA P . 
B 1 120 GLU 120 120 120 GLU GLU P . 
B 1 121 GLY 121 121 121 GLY GLY P . 
B 1 122 HIS 122 122 122 HIS HIS P . 
B 1 123 LEU 123 123 123 LEU LEU P . 
B 1 124 ARG 124 124 124 ARG ARG P . 
B 1 125 GLY 125 125 125 GLY GLY P . 
B 1 126 GLY 126 126 126 GLY GLY P . 
B 1 127 ALA 127 127 127 ALA ALA P . 
B 1 128 ARG 128 128 128 ARG ARG P . 
B 1 129 LYS 129 129 129 LYS LYS P . 
B 1 130 VAL 130 130 130 VAL VAL P . 
B 1 131 VAL 131 131 131 VAL VAL P . 
B 1 132 ILE 132 132 132 ILE ILE P . 
B 1 133 SER 133 133 133 SER SER P . 
B 1 134 ALA 134 134 134 ALA ALA P . 
B 1 135 PRO 135 135 135 PRO PRO P . 
B 1 136 ALA 136 136 136 ALA ALA P . 
B 1 137 SER 137 137 137 SER SER P . 
B 1 138 GLY 138 138 138 GLY GLY P . 
B 1 139 GLY 139 139 139 GLY GLY P . 
B 1 140 ALA 140 140 140 ALA ALA P . 
B 1 141 LYS 141 141 141 LYS LYS P . 
B 1 142 THR 142 142 142 THR THR P . 
B 1 143 PHE 143 143 143 PHE PHE P . 
B 1 144 VAL 144 144 144 VAL VAL P . 
B 1 145 MET 145 145 145 MET MET P . 
B 1 146 GLY 146 146 146 GLY GLY P . 
B 1 147 VAL 147 147 147 VAL VAL P . 
B 1 148 ASN 148 148 148 ASN ASN P . 
B 1 149 HIS 149 149 149 HIS HIS P . 
B 1 150 ASN 150 150 150 ASN ASN P . 
B 1 151 ASN 151 151 151 ASN ASN P . 
B 1 152 TYR 152 152 152 TYR TYR P . 
B 1 153 ASN 153 153 153 ASN ASN P . 
B 1 154 PRO 154 154 154 PRO PRO P . 
B 1 155 ARG 155 155 155 ARG ARG P . 
B 1 156 GLU 156 156 156 GLU GLU P . 
B 1 157 GLN 157 157 157 GLN GLN P . 
B 1 158 HIS 158 158 158 HIS HIS P . 
B 1 159 VAL 159 159 159 VAL VAL P . 
B 1 160 VAL 160 160 160 VAL VAL P . 
B 1 161 SER 161 161 161 SER SER P . 
B 1 162 ASN 162 162 162 ASN ASN P . 
B 1 163 ALA 163 163 163 ALA ALA P . 
B 1 164 SER 164 164 164 SER SER P . 
B 1 165 CYS 165 165 165 CYS CYS P . 
B 1 166 THR 166 166 166 THR THR P . 
B 1 167 THR 167 167 167 THR THR P . 
B 1 168 ASN 168 168 168 ASN ASN P . 
B 1 169 CYS 169 169 169 CYS CYS P . 
B 1 170 LEU 170 170 170 LEU LEU P . 
B 1 171 ALA 171 171 171 ALA ALA P . 
B 1 172 PRO 172 172 172 PRO PRO P . 
B 1 173 LEU 173 173 173 LEU LEU P . 
B 1 174 VAL 174 174 174 VAL VAL P . 
B 1 175 HIS 175 175 175 HIS HIS P . 
B 1 176 VAL 176 176 176 VAL VAL P . 
B 1 177 LEU 177 177 177 LEU LEU P . 
B 1 178 VAL 178 178 178 VAL VAL P . 
B 1 179 LYS 179 179 179 LYS LYS P . 
B 1 180 GLU 180 180 180 GLU GLU P . 
B 1 181 GLY 181 181 181 GLY GLY P . 
B 1 182 PHE 182 182 182 PHE PHE P . 
B 1 183 GLY 183 183 183 GLY GLY P . 
B 1 184 ILE 184 184 184 ILE ILE P . 
B 1 185 SER 185 185 185 SER SER P . 
B 1 186 THR 186 186 186 THR THR P . 
B 1 187 GLY 187 187 187 GLY GLY P . 
B 1 188 LEU 188 188 188 LEU LEU P . 
B 1 189 MET 189 189 189 MET MET P . 
B 1 190 THR 190 190 190 THR THR P . 
B 1 191 THR 191 191 191 THR THR P . 
B 1 192 VAL 192 192 192 VAL VAL P . 
B 1 193 HIS 193 193 193 HIS HIS P . 
B 1 194 SER 194 194 194 SER SER P . 
B 1 195 TYR 195 195 195 TYR TYR P . 
B 1 196 THR 196 196 196 THR THR P . 
B 1 197 ALA 197 197 197 ALA ALA P . 
B 1 198 THR 198 198 198 THR THR P . 
B 1 199 GLN 199 199 199 GLN GLN P . 
B 1 200 LYS 200 200 200 LYS LYS P . 
B 1 201 THR 201 201 201 THR THR P . 
B 1 202 VAL 202 202 202 VAL VAL P . 
B 1 203 ASP 203 203 203 ASP ASP P . 
B 1 204 GLY 204 204 204 GLY GLY P . 
B 1 205 VAL 205 205 205 VAL VAL P . 
B 1 206 SER 206 206 206 SER SER P . 
B 1 207 VAL 207 207 207 VAL VAL P . 
B 1 208 LYS 208 208 208 LYS LYS P . 
B 1 209 ASP 209 209 209 ASP ASP P . 
B 1 210 TRP 210 210 210 TRP TRP P . 
B 1 211 ARG 211 211 211 ARG ARG P . 
B 1 212 GLY 212 212 212 GLY GLY P . 
B 1 213 GLY 213 213 213 GLY GLY P . 
B 1 214 ARG 214 214 214 ARG ARG P . 
B 1 215 ALA 215 215 215 ALA ALA P . 
B 1 216 ALA 216 216 216 ALA ALA P . 
B 1 217 ALA 217 217 217 ALA ALA P . 
B 1 218 LEU 218 218 218 LEU LEU P . 
B 1 219 ASN 219 219 219 ASN ASN P . 
B 1 220 ILE 220 220 220 ILE ILE P . 
B 1 221 ILE 221 221 221 ILE ILE P . 
B 1 222 PRO 222 222 222 PRO PRO P . 
B 1 223 SER 223 223 223 SER SER P . 
B 1 224 THR 224 224 224 THR THR P . 
B 1 225 THR 225 225 225 THR THR P . 
B 1 226 GLY 226 226 226 GLY GLY P . 
B 1 227 ALA 227 227 227 ALA ALA P . 
B 1 228 ALA 228 228 228 ALA ALA P . 
B 1 229 LYS 229 229 229 LYS LYS P . 
B 1 230 ALA 230 230 230 ALA ALA P . 
B 1 231 VAL 231 231 231 VAL VAL P . 
B 1 232 GLY 232 232 232 GLY GLY P . 
B 1 233 MET 233 233 233 MET MET P . 
B 1 234 VAL 234 234 234 VAL VAL P . 
B 1 235 ILE 235 235 235 ILE ILE P . 
B 1 236 PRO 236 236 236 PRO PRO P . 
B 1 237 SER 237 237 237 SER SER P . 
B 1 238 THR 238 238 238 THR THR P . 
B 1 239 GLN 239 239 239 GLN GLN P . 
B 1 240 GLY 240 240 240 GLY GLY P . 
B 1 241 LYS 241 241 241 LYS LYS P . 
B 1 242 LEU 242 242 242 LEU LEU P . 
B 1 243 THR 243 243 243 THR THR P . 
B 1 244 GLY 244 244 244 GLY GLY P . 
B 1 245 MET 245 245 245 MET MET P . 
B 1 246 ALA 246 246 246 ALA ALA P . 
B 1 247 PHE 247 247 247 PHE PHE P . 
B 1 248 ARG 248 248 248 ARG ARG P . 
B 1 249 VAL 249 249 249 VAL VAL P . 
B 1 250 PRO 250 250 250 PRO PRO P . 
B 1 251 THR 251 251 251 THR THR P . 
B 1 252 ALA 252 252 252 ALA ALA P . 
B 1 253 ASP 253 253 253 ASP ASP P . 
B 1 254 VAL 254 254 254 VAL VAL P . 
B 1 255 SER 255 255 255 SER SER P . 
B 1 256 VAL 256 256 256 VAL VAL P . 
B 1 257 VAL 257 257 257 VAL VAL P . 
B 1 258 ASP 258 258 258 ASP ASP P . 
B 1 259 LEU 259 259 259 LEU LEU P . 
B 1 260 THR 260 260 260 THR THR P . 
B 1 261 PHE 261 261 261 PHE PHE P . 
B 1 262 ILE 262 262 262 ILE ILE P . 
B 1 263 ALA 263 263 263 ALA ALA P . 
B 1 264 THR 264 264 264 THR THR P . 
B 1 265 ARG 265 265 265 ARG ARG P . 
B 1 266 ASP 266 266 266 ASP ASP P . 
B 1 267 THR 267 267 267 THR THR P . 
B 1 268 SER 268 268 268 SER SER P . 
B 1 269 ILE 269 269 269 ILE ILE P . 
B 1 270 LYS 270 270 270 LYS LYS P . 
B 1 271 GLU 271 271 271 GLU GLU P . 
B 1 272 ILE 272 272 272 ILE ILE P . 
B 1 273 ASP 273 273 273 ASP ASP P . 
B 1 274 ALA 274 274 274 ALA ALA P . 
B 1 275 ALA 275 275 275 ALA ALA P . 
B 1 276 LEU 276 276 276 LEU LEU P . 
B 1 277 LYS 277 277 277 LYS LYS P . 
B 1 278 ARG 278 278 278 ARG ARG P . 
B 1 279 ALA 279 279 279 ALA ALA P . 
B 1 280 SER 280 280 280 SER SER P . 
B 1 281 LYS 281 281 281 LYS LYS P . 
B 1 282 THR 282 282 282 THR THR P . 
B 1 283 TYR 283 283 283 TYR TYR P . 
B 1 284 MET 284 284 284 MET MET P . 
B 1 285 LYS 285 285 285 LYS LYS P . 
B 1 286 ASN 286 286 286 ASN ASN P . 
B 1 287 ILE 287 287 287 ILE ILE P . 
B 1 288 LEU 288 288 288 LEU LEU P . 
B 1 289 GLY 289 289 289 GLY GLY P . 
B 1 290 TYR 290 290 290 TYR TYR P . 
B 1 291 THR 291 291 291 THR THR P . 
B 1 292 ASP 292 292 292 ASP ASP P . 
B 1 293 GLU 293 293 293 GLU GLU P . 
B 1 294 GLU 294 294 294 GLU GLU P . 
B 1 295 LEU 295 295 295 LEU LEU P . 
B 1 296 VAL 296 296 296 VAL VAL P . 
B 1 297 SER 297 297 297 SER SER P . 
B 1 298 ALA 298 298 298 ALA ALA P . 
B 1 299 ASP 299 299 299 ASP ASP P . 
B 1 300 PHE 300 300 300 PHE PHE P . 
B 1 301 ILE 301 301 301 ILE ILE P . 
B 1 302 SER 302 302 302 SER SER P . 
B 1 303 ASP 303 303 303 ASP ASP P . 
B 1 304 SER 304 304 304 SER SER P . 
B 1 305 ARG 305 305 305 ARG ARG P . 
B 1 306 SER 306 306 306 SER SER P . 
B 1 307 SER 307 307 307 SER SER P . 
B 1 308 ILE 308 308 308 ILE ILE P . 
B 1 309 TYR 309 309 309 TYR TYR P . 
B 1 310 ASP 310 310 310 ASP ASP P . 
B 1 311 SER 311 311 311 SER SER P . 
B 1 312 LYS 312 312 312 LYS LYS P . 
B 1 313 ALA 313 313 313 ALA ALA P . 
B 1 314 THR 314 314 314 THR THR P . 
B 1 315 LEU 315 315 315 LEU LEU P . 
B 1 316 GLN 316 316 316 GLN GLN P . 
B 1 317 ASN 317 317 317 ASN ASN P . 
B 1 318 ASN 318 318 318 ASN ASN P . 
B 1 319 LEU 319 319 319 LEU LEU P . 
B 1 320 PRO 320 320 320 PRO PRO P . 
B 1 321 ASN 321 321 321 ASN ASN P . 
B 1 322 GLU 322 322 322 GLU GLU P . 
B 1 323 ARG 323 323 323 ARG ARG P . 
B 1 324 ARG 324 324 324 ARG ARG P . 
B 1 325 PHE 325 325 325 PHE PHE P . 
B 1 326 PHE 326 326 326 PHE PHE P . 
B 1 327 LYS 327 327 327 LYS LYS P . 
B 1 328 ILE 328 328 328 ILE ILE P . 
B 1 329 VAL 329 329 329 VAL VAL P . 
B 1 330 SER 330 330 330 SER SER P . 
B 1 331 TRP 331 331 331 TRP TRP P . 
B 1 332 TYR 332 332 332 TYR TYR P . 
B 1 333 ASP 333 333 333 ASP ASP P . 
B 1 334 ASN 334 334 334 ASN ASN P . 
B 1 335 GLU 335 335 335 GLU GLU P . 
B 1 336 TRP 336 336 336 TRP TRP P . 
B 1 337 GLY 337 337 337 GLY GLY P . 
B 1 338 TYR 338 338 338 TYR TYR P . 
B 1 339 SER 339 339 339 SER SER P . 
B 1 340 HIS 340 340 340 HIS HIS P . 
B 1 341 ARG 341 341 341 ARG ARG P . 
B 1 342 VAL 342 342 342 VAL VAL P . 
B 1 343 VAL 343 343 343 VAL VAL P . 
B 1 344 ASP 344 344 344 ASP ASP P . 
B 1 345 LEU 345 345 345 LEU LEU P . 
B 1 346 VAL 346 346 346 VAL VAL P . 
B 1 347 ARG 347 347 347 ARG ARG P . 
B 1 348 HIS 348 348 348 HIS HIS P . 
B 1 349 MET 349 349 349 MET MET P . 
B 1 350 ALA 350 350 350 ALA ALA P . 
B 1 351 ALA 351 351 351 ALA ALA P . 
B 1 352 ARG 352 352 352 ARG ARG P . 
B 1 353 ASP 353 353 353 ASP ASP P . 
B 1 354 ARG 354 354 354 ARG ARG P . 
B 1 355 ALA 355 355 355 ALA ALA P . 
B 1 356 ALA 356 356 356 ALA ALA P . 
B 1 357 LYS 357 357 357 LYS LYS P . 
B 1 358 LEU 358 358 358 LEU LEU P . 
C 1 1   THR 1   1   1   THR THR Q . 
C 1 2   ILE 2   2   2   ILE ILE Q . 
C 1 3   LYS 3   3   3   LYS LYS Q . 
C 1 4   VAL 4   4   4   VAL VAL Q . 
C 1 5   GLY 5   5   5   GLY GLY Q . 
C 1 6   ILE 6   6   6   ILE ILE Q . 
C 1 7   ASN 7   7   7   ASN ASN Q . 
C 1 8   GLY 8   8   8   GLY GLY Q . 
C 1 9   PHE 9   9   9   PHE PHE Q . 
C 1 10  GLY 10  10  10  GLY GLY Q . 
C 1 11  ARG 11  11  11  ARG ARG Q . 
C 1 12  ILE 12  12  12  ILE ILE Q . 
C 1 13  GLY 13  13  13  GLY GLY Q . 
C 1 14  ARG 14  14  14  ARG ARG Q . 
C 1 15  MET 15  15  15  MET MET Q . 
C 1 16  VAL 16  16  16  VAL VAL Q . 
C 1 17  PHE 17  17  17  PHE PHE Q . 
C 1 18  GLN 18  18  18  GLN GLN Q . 
C 1 19  ALA 19  19  19  ALA ALA Q . 
C 1 20  LEU 20  20  20  LEU LEU Q . 
C 1 21  CYS 21  21  21  CYS CYS Q . 
C 1 22  ASP 22  22  22  ASP ASP Q . 
C 1 23  ASP 23  23  23  ASP ASP Q . 
C 1 24  GLY 24  24  24  GLY GLY Q . 
C 1 25  LEU 25  25  25  LEU LEU Q . 
C 1 26  LEU 26  26  26  LEU LEU Q . 
C 1 27  GLY 27  27  27  GLY GLY Q . 
C 1 28  ASN 28  28  28  ASN ASN Q . 
C 1 29  GLU 29  29  29  GLU GLU Q . 
C 1 30  ILE 30  30  30  ILE ILE Q . 
C 1 31  ASP 31  31  31  ASP ASP Q . 
C 1 32  VAL 32  32  32  VAL VAL Q . 
C 1 33  VAL 33  33  33  VAL VAL Q . 
C 1 34  ALA 34  34  34  ALA ALA Q . 
C 1 35  VAL 35  35  35  VAL VAL Q . 
C 1 36  VAL 36  36  36  VAL VAL Q . 
C 1 37  ASP 37  37  37  ASP ASP Q . 
C 1 38  MET 38  38  38  MET MET Q . 
C 1 39  ASN 39  39  39  ASN ASN Q . 
C 1 40  THR 40  40  40  THR THR Q . 
C 1 41  ASP 41  41  41  ASP ASP Q . 
C 1 42  ALA 42  42  42  ALA ALA Q . 
C 1 43  ARG 43  43  43  ARG ARG Q . 
C 1 44  TYR 44  44  44  TYR TYR Q . 
C 1 45  PHE 45  45  45  PHE PHE Q . 
C 1 46  ALA 46  46  46  ALA ALA Q . 
C 1 47  TYR 47  47  47  TYR TYR Q . 
C 1 48  GLN 48  48  48  GLN GLN Q . 
C 1 49  MET 49  49  49  MET MET Q . 
C 1 50  LYS 50  50  50  LYS LYS Q . 
C 1 51  TYR 51  51  51  TYR TYR Q . 
C 1 52  ASP 52  52  52  ASP ASP Q . 
C 1 53  SER 53  53  53  SER SER Q . 
C 1 54  VAL 54  54  54  VAL VAL Q . 
C 1 55  HIS 55  55  55  HIS HIS Q . 
C 1 56  GLY 56  56  56  GLY GLY Q . 
C 1 57  LYS 57  57  57  LYS LYS Q . 
C 1 58  PHE 58  58  58  PHE PHE Q . 
C 1 59  LYS 59  59  59  LYS LYS Q . 
C 1 60  HIS 60  60  60  HIS HIS Q . 
C 1 61  SER 61  61  61  SER SER Q . 
C 1 62  VAL 62  62  62  VAL VAL Q . 
C 1 63  SER 63  63  63  SER SER Q . 
C 1 64  THR 64  64  64  THR THR Q . 
C 1 65  THR 65  65  65  THR THR Q . 
C 1 66  LYS 66  66  66  LYS LYS Q . 
C 1 67  SER 67  67  67  SER SER Q . 
C 1 68  LYS 68  68  68  LYS LYS Q . 
C 1 69  PRO 69  69  69  PRO PRO Q . 
C 1 70  SER 70  70  70  SER SER Q . 
C 1 71  VAL 71  71  71  VAL VAL Q . 
C 1 72  ALA 72  72  72  ALA ALA Q . 
C 1 73  LYS 73  73  73  LYS LYS Q . 
C 1 74  ASP 74  74  74  ASP ASP Q . 
C 1 75  ASP 75  75  75  ASP ASP Q . 
C 1 76  THR 76  76  76  THR THR Q . 
C 1 77  LEU 77  77  77  LEU LEU Q . 
C 1 78  VAL 78  78  78  VAL VAL Q . 
C 1 79  VAL 79  79  79  VAL VAL Q . 
C 1 80  ASN 80  80  80  ASN ASN Q . 
C 1 81  GLY 81  81  81  GLY GLY Q . 
C 1 82  HIS 82  82  82  HIS HIS Q . 
C 1 83  ARG 83  83  83  ARG ARG Q . 
C 1 84  ILE 84  84  84  ILE ILE Q . 
C 1 85  LEU 85  85  85  LEU LEU Q . 
C 1 86  CYS 86  86  86  CYS CYS Q . 
C 1 87  VAL 87  87  87  VAL VAL Q . 
C 1 88  LYS 88  88  88  LYS LYS Q . 
C 1 89  ALA 89  89  89  ALA ALA Q . 
C 1 90  GLN 90  90  90  GLN GLN Q . 
C 1 91  ARG 91  91  91  ARG ARG Q . 
C 1 92  ASN 92  92  92  ASN ASN Q . 
C 1 93  PRO 93  93  93  PRO PRO Q . 
C 1 94  ALA 94  94  94  ALA ALA Q . 
C 1 95  ASP 95  95  95  ASP ASP Q . 
C 1 96  LEU 96  96  96  LEU LEU Q . 
C 1 97  PRO 97  97  97  PRO PRO Q . 
C 1 98  TRP 98  98  98  TRP TRP Q . 
C 1 99  GLY 99  99  99  GLY GLY Q . 
C 1 100 LYS 100 100 100 LYS LYS Q . 
C 1 101 LEU 101 101 101 LEU LEU Q . 
C 1 102 GLY 102 102 102 GLY GLY Q . 
C 1 103 VAL 103 103 103 VAL VAL Q . 
C 1 104 GLU 104 104 104 GLU GLU Q . 
C 1 105 TYR 105 105 105 TYR TYR Q . 
C 1 106 VAL 106 106 106 VAL VAL Q . 
C 1 107 ILE 107 107 107 ILE ILE Q . 
C 1 108 GLU 108 108 108 GLU GLU Q . 
C 1 109 SER 109 109 109 SER SER Q . 
C 1 110 THR 110 110 110 THR THR Q . 
C 1 111 GLY 111 111 111 GLY GLY Q . 
C 1 112 LEU 112 112 112 LEU LEU Q . 
C 1 113 PHE 113 113 113 PHE PHE Q . 
C 1 114 THR 114 114 114 THR THR Q . 
C 1 115 VAL 115 115 115 VAL VAL Q . 
C 1 116 LYS 116 116 116 LYS LYS Q . 
C 1 117 SER 117 117 117 SER SER Q . 
C 1 118 ALA 118 118 118 ALA ALA Q . 
C 1 119 ALA 119 119 119 ALA ALA Q . 
C 1 120 GLU 120 120 120 GLU GLU Q . 
C 1 121 GLY 121 121 121 GLY GLY Q . 
C 1 122 HIS 122 122 122 HIS HIS Q . 
C 1 123 LEU 123 123 123 LEU LEU Q . 
C 1 124 ARG 124 124 124 ARG ARG Q . 
C 1 125 GLY 125 125 125 GLY GLY Q . 
C 1 126 GLY 126 126 126 GLY GLY Q . 
C 1 127 ALA 127 127 127 ALA ALA Q . 
C 1 128 ARG 128 128 128 ARG ARG Q . 
C 1 129 LYS 129 129 129 LYS LYS Q . 
C 1 130 VAL 130 130 130 VAL VAL Q . 
C 1 131 VAL 131 131 131 VAL VAL Q . 
C 1 132 ILE 132 132 132 ILE ILE Q . 
C 1 133 SER 133 133 133 SER SER Q . 
C 1 134 ALA 134 134 134 ALA ALA Q . 
C 1 135 PRO 135 135 135 PRO PRO Q . 
C 1 136 ALA 136 136 136 ALA ALA Q . 
C 1 137 SER 137 137 137 SER SER Q . 
C 1 138 GLY 138 138 138 GLY GLY Q . 
C 1 139 GLY 139 139 139 GLY GLY Q . 
C 1 140 ALA 140 140 140 ALA ALA Q . 
C 1 141 LYS 141 141 141 LYS LYS Q . 
C 1 142 THR 142 142 142 THR THR Q . 
C 1 143 PHE 143 143 143 PHE PHE Q . 
C 1 144 VAL 144 144 144 VAL VAL Q . 
C 1 145 MET 145 145 145 MET MET Q . 
C 1 146 GLY 146 146 146 GLY GLY Q . 
C 1 147 VAL 147 147 147 VAL VAL Q . 
C 1 148 ASN 148 148 148 ASN ASN Q . 
C 1 149 HIS 149 149 149 HIS HIS Q . 
C 1 150 ASN 150 150 150 ASN ASN Q . 
C 1 151 ASN 151 151 151 ASN ASN Q . 
C 1 152 TYR 152 152 152 TYR TYR Q . 
C 1 153 ASN 153 153 153 ASN ASN Q . 
C 1 154 PRO 154 154 154 PRO PRO Q . 
C 1 155 ARG 155 155 155 ARG ARG Q . 
C 1 156 GLU 156 156 156 GLU GLU Q . 
C 1 157 GLN 157 157 157 GLN GLN Q . 
C 1 158 HIS 158 158 158 HIS HIS Q . 
C 1 159 VAL 159 159 159 VAL VAL Q . 
C 1 160 VAL 160 160 160 VAL VAL Q . 
C 1 161 SER 161 161 161 SER SER Q . 
C 1 162 ASN 162 162 162 ASN ASN Q . 
C 1 163 ALA 163 163 163 ALA ALA Q . 
C 1 164 SER 164 164 164 SER SER Q . 
C 1 165 CYS 165 165 165 CYS CYS Q . 
C 1 166 THR 166 166 166 THR THR Q . 
C 1 167 THR 167 167 167 THR THR Q . 
C 1 168 ASN 168 168 168 ASN ASN Q . 
C 1 169 CYS 169 169 169 CYS CYS Q . 
C 1 170 LEU 170 170 170 LEU LEU Q . 
C 1 171 ALA 171 171 171 ALA ALA Q . 
C 1 172 PRO 172 172 172 PRO PRO Q . 
C 1 173 LEU 173 173 173 LEU LEU Q . 
C 1 174 VAL 174 174 174 VAL VAL Q . 
C 1 175 HIS 175 175 175 HIS HIS Q . 
C 1 176 VAL 176 176 176 VAL VAL Q . 
C 1 177 LEU 177 177 177 LEU LEU Q . 
C 1 178 VAL 178 178 178 VAL VAL Q . 
C 1 179 LYS 179 179 179 LYS LYS Q . 
C 1 180 GLU 180 180 180 GLU GLU Q . 
C 1 181 GLY 181 181 181 GLY GLY Q . 
C 1 182 PHE 182 182 182 PHE PHE Q . 
C 1 183 GLY 183 183 183 GLY GLY Q . 
C 1 184 ILE 184 184 184 ILE ILE Q . 
C 1 185 SER 185 185 185 SER SER Q . 
C 1 186 THR 186 186 186 THR THR Q . 
C 1 187 GLY 187 187 187 GLY GLY Q . 
C 1 188 LEU 188 188 188 LEU LEU Q . 
C 1 189 MET 189 189 189 MET MET Q . 
C 1 190 THR 190 190 190 THR THR Q . 
C 1 191 THR 191 191 191 THR THR Q . 
C 1 192 VAL 192 192 192 VAL VAL Q . 
C 1 193 HIS 193 193 193 HIS HIS Q . 
C 1 194 SER 194 194 194 SER SER Q . 
C 1 195 TYR 195 195 195 TYR TYR Q . 
C 1 196 THR 196 196 196 THR THR Q . 
C 1 197 ALA 197 197 197 ALA ALA Q . 
C 1 198 THR 198 198 198 THR THR Q . 
C 1 199 GLN 199 199 199 GLN GLN Q . 
C 1 200 LYS 200 200 200 LYS LYS Q . 
C 1 201 THR 201 201 201 THR THR Q . 
C 1 202 VAL 202 202 202 VAL VAL Q . 
C 1 203 ASP 203 203 203 ASP ASP Q . 
C 1 204 GLY 204 204 204 GLY GLY Q . 
C 1 205 VAL 205 205 205 VAL VAL Q . 
C 1 206 SER 206 206 206 SER SER Q . 
C 1 207 VAL 207 207 207 VAL VAL Q . 
C 1 208 LYS 208 208 208 LYS LYS Q . 
C 1 209 ASP 209 209 209 ASP ASP Q . 
C 1 210 TRP 210 210 210 TRP TRP Q . 
C 1 211 ARG 211 211 211 ARG ARG Q . 
C 1 212 GLY 212 212 212 GLY GLY Q . 
C 1 213 GLY 213 213 213 GLY GLY Q . 
C 1 214 ARG 214 214 214 ARG ARG Q . 
C 1 215 ALA 215 215 215 ALA ALA Q . 
C 1 216 ALA 216 216 216 ALA ALA Q . 
C 1 217 ALA 217 217 217 ALA ALA Q . 
C 1 218 LEU 218 218 218 LEU LEU Q . 
C 1 219 ASN 219 219 219 ASN ASN Q . 
C 1 220 ILE 220 220 220 ILE ILE Q . 
C 1 221 ILE 221 221 221 ILE ILE Q . 
C 1 222 PRO 222 222 222 PRO PRO Q . 
C 1 223 SER 223 223 223 SER SER Q . 
C 1 224 THR 224 224 224 THR THR Q . 
C 1 225 THR 225 225 225 THR THR Q . 
C 1 226 GLY 226 226 226 GLY GLY Q . 
C 1 227 ALA 227 227 227 ALA ALA Q . 
C 1 228 ALA 228 228 228 ALA ALA Q . 
C 1 229 LYS 229 229 229 LYS LYS Q . 
C 1 230 ALA 230 230 230 ALA ALA Q . 
C 1 231 VAL 231 231 231 VAL VAL Q . 
C 1 232 GLY 232 232 232 GLY GLY Q . 
C 1 233 MET 233 233 233 MET MET Q . 
C 1 234 VAL 234 234 234 VAL VAL Q . 
C 1 235 ILE 235 235 235 ILE ILE Q . 
C 1 236 PRO 236 236 236 PRO PRO Q . 
C 1 237 SER 237 237 237 SER SER Q . 
C 1 238 THR 238 238 238 THR THR Q . 
C 1 239 GLN 239 239 239 GLN GLN Q . 
C 1 240 GLY 240 240 240 GLY GLY Q . 
C 1 241 LYS 241 241 241 LYS LYS Q . 
C 1 242 LEU 242 242 242 LEU LEU Q . 
C 1 243 THR 243 243 243 THR THR Q . 
C 1 244 GLY 244 244 244 GLY GLY Q . 
C 1 245 MET 245 245 245 MET MET Q . 
C 1 246 ALA 246 246 246 ALA ALA Q . 
C 1 247 PHE 247 247 247 PHE PHE Q . 
C 1 248 ARG 248 248 248 ARG ARG Q . 
C 1 249 VAL 249 249 249 VAL VAL Q . 
C 1 250 PRO 250 250 250 PRO PRO Q . 
C 1 251 THR 251 251 251 THR THR Q . 
C 1 252 ALA 252 252 252 ALA ALA Q . 
C 1 253 ASP 253 253 253 ASP ASP Q . 
C 1 254 VAL 254 254 254 VAL VAL Q . 
C 1 255 SER 255 255 255 SER SER Q . 
C 1 256 VAL 256 256 256 VAL VAL Q . 
C 1 257 VAL 257 257 257 VAL VAL Q . 
C 1 258 ASP 258 258 258 ASP ASP Q . 
C 1 259 LEU 259 259 259 LEU LEU Q . 
C 1 260 THR 260 260 260 THR THR Q . 
C 1 261 PHE 261 261 261 PHE PHE Q . 
C 1 262 ILE 262 262 262 ILE ILE Q . 
C 1 263 ALA 263 263 263 ALA ALA Q . 
C 1 264 THR 264 264 264 THR THR Q . 
C 1 265 ARG 265 265 265 ARG ARG Q . 
C 1 266 ASP 266 266 266 ASP ASP Q . 
C 1 267 THR 267 267 267 THR THR Q . 
C 1 268 SER 268 268 268 SER SER Q . 
C 1 269 ILE 269 269 269 ILE ILE Q . 
C 1 270 LYS 270 270 270 LYS LYS Q . 
C 1 271 GLU 271 271 271 GLU GLU Q . 
C 1 272 ILE 272 272 272 ILE ILE Q . 
C 1 273 ASP 273 273 273 ASP ASP Q . 
C 1 274 ALA 274 274 274 ALA ALA Q . 
C 1 275 ALA 275 275 275 ALA ALA Q . 
C 1 276 LEU 276 276 276 LEU LEU Q . 
C 1 277 LYS 277 277 277 LYS LYS Q . 
C 1 278 ARG 278 278 278 ARG ARG Q . 
C 1 279 ALA 279 279 279 ALA ALA Q . 
C 1 280 SER 280 280 280 SER SER Q . 
C 1 281 LYS 281 281 281 LYS LYS Q . 
C 1 282 THR 282 282 282 THR THR Q . 
C 1 283 TYR 283 283 283 TYR TYR Q . 
C 1 284 MET 284 284 284 MET MET Q . 
C 1 285 LYS 285 285 285 LYS LYS Q . 
C 1 286 ASN 286 286 286 ASN ASN Q . 
C 1 287 ILE 287 287 287 ILE ILE Q . 
C 1 288 LEU 288 288 288 LEU LEU Q . 
C 1 289 GLY 289 289 289 GLY GLY Q . 
C 1 290 TYR 290 290 290 TYR TYR Q . 
C 1 291 THR 291 291 291 THR THR Q . 
C 1 292 ASP 292 292 292 ASP ASP Q . 
C 1 293 GLU 293 293 293 GLU GLU Q . 
C 1 294 GLU 294 294 294 GLU GLU Q . 
C 1 295 LEU 295 295 295 LEU LEU Q . 
C 1 296 VAL 296 296 296 VAL VAL Q . 
C 1 297 SER 297 297 297 SER SER Q . 
C 1 298 ALA 298 298 298 ALA ALA Q . 
C 1 299 ASP 299 299 299 ASP ASP Q . 
C 1 300 PHE 300 300 300 PHE PHE Q . 
C 1 301 ILE 301 301 301 ILE ILE Q . 
C 1 302 SER 302 302 302 SER SER Q . 
C 1 303 ASP 303 303 303 ASP ASP Q . 
C 1 304 SER 304 304 304 SER SER Q . 
C 1 305 ARG 305 305 305 ARG ARG Q . 
C 1 306 SER 306 306 306 SER SER Q . 
C 1 307 SER 307 307 307 SER SER Q . 
C 1 308 ILE 308 308 308 ILE ILE Q . 
C 1 309 TYR 309 309 309 TYR TYR Q . 
C 1 310 ASP 310 310 310 ASP ASP Q . 
C 1 311 SER 311 311 311 SER SER Q . 
C 1 312 LYS 312 312 312 LYS LYS Q . 
C 1 313 ALA 313 313 313 ALA ALA Q . 
C 1 314 THR 314 314 314 THR THR Q . 
C 1 315 LEU 315 315 315 LEU LEU Q . 
C 1 316 GLN 316 316 316 GLN GLN Q . 
C 1 317 ASN 317 317 317 ASN ASN Q . 
C 1 318 ASN 318 318 318 ASN ASN Q . 
C 1 319 LEU 319 319 319 LEU LEU Q . 
C 1 320 PRO 320 320 320 PRO PRO Q . 
C 1 321 ASN 321 321 321 ASN ASN Q . 
C 1 322 GLU 322 322 322 GLU GLU Q . 
C 1 323 ARG 323 323 323 ARG ARG Q . 
C 1 324 ARG 324 324 324 ARG ARG Q . 
C 1 325 PHE 325 325 325 PHE PHE Q . 
C 1 326 PHE 326 326 326 PHE PHE Q . 
C 1 327 LYS 327 327 327 LYS LYS Q . 
C 1 328 ILE 328 328 328 ILE ILE Q . 
C 1 329 VAL 329 329 329 VAL VAL Q . 
C 1 330 SER 330 330 330 SER SER Q . 
C 1 331 TRP 331 331 331 TRP TRP Q . 
C 1 332 TYR 332 332 332 TYR TYR Q . 
C 1 333 ASP 333 333 333 ASP ASP Q . 
C 1 334 ASN 334 334 334 ASN ASN Q . 
C 1 335 GLU 335 335 335 GLU GLU Q . 
C 1 336 TRP 336 336 336 TRP TRP Q . 
C 1 337 GLY 337 337 337 GLY GLY Q . 
C 1 338 TYR 338 338 338 TYR TYR Q . 
C 1 339 SER 339 339 339 SER SER Q . 
C 1 340 HIS 340 340 340 HIS HIS Q . 
C 1 341 ARG 341 341 341 ARG ARG Q . 
C 1 342 VAL 342 342 342 VAL VAL Q . 
C 1 343 VAL 343 343 343 VAL VAL Q . 
C 1 344 ASP 344 344 344 ASP ASP Q . 
C 1 345 LEU 345 345 345 LEU LEU Q . 
C 1 346 VAL 346 346 346 VAL VAL Q . 
C 1 347 ARG 347 347 347 ARG ARG Q . 
C 1 348 HIS 348 348 348 HIS HIS Q . 
C 1 349 MET 349 349 349 MET MET Q . 
C 1 350 ALA 350 350 350 ALA ALA Q . 
C 1 351 ALA 351 351 351 ALA ALA Q . 
C 1 352 ARG 352 352 352 ARG ARG Q . 
C 1 353 ASP 353 353 353 ASP ASP Q . 
C 1 354 ARG 354 354 354 ARG ARG Q . 
C 1 355 ALA 355 355 355 ALA ALA Q . 
C 1 356 ALA 356 356 356 ALA ALA Q . 
C 1 357 LYS 357 357 357 LYS LYS Q . 
C 1 358 LEU 358 358 358 LEU LEU Q . 
D 1 1   THR 1   1   1   THR THR R . 
D 1 2   ILE 2   2   2   ILE ILE R . 
D 1 3   LYS 3   3   3   LYS LYS R . 
D 1 4   VAL 4   4   4   VAL VAL R . 
D 1 5   GLY 5   5   5   GLY GLY R . 
D 1 6   ILE 6   6   6   ILE ILE R . 
D 1 7   ASN 7   7   7   ASN ASN R . 
D 1 8   GLY 8   8   8   GLY GLY R . 
D 1 9   PHE 9   9   9   PHE PHE R . 
D 1 10  GLY 10  10  10  GLY GLY R . 
D 1 11  ARG 11  11  11  ARG ARG R . 
D 1 12  ILE 12  12  12  ILE ILE R . 
D 1 13  GLY 13  13  13  GLY GLY R . 
D 1 14  ARG 14  14  14  ARG ARG R . 
D 1 15  MET 15  15  15  MET MET R . 
D 1 16  VAL 16  16  16  VAL VAL R . 
D 1 17  PHE 17  17  17  PHE PHE R . 
D 1 18  GLN 18  18  18  GLN GLN R . 
D 1 19  ALA 19  19  19  ALA ALA R . 
D 1 20  LEU 20  20  20  LEU LEU R . 
D 1 21  CYS 21  21  21  CYS CYS R . 
D 1 22  ASP 22  22  22  ASP ASP R . 
D 1 23  ASP 23  23  23  ASP ASP R . 
D 1 24  GLY 24  24  24  GLY GLY R . 
D 1 25  LEU 25  25  25  LEU LEU R . 
D 1 26  LEU 26  26  26  LEU LEU R . 
D 1 27  GLY 27  27  27  GLY GLY R . 
D 1 28  ASN 28  28  28  ASN ASN R . 
D 1 29  GLU 29  29  29  GLU GLU R . 
D 1 30  ILE 30  30  30  ILE ILE R . 
D 1 31  ASP 31  31  31  ASP ASP R . 
D 1 32  VAL 32  32  32  VAL VAL R . 
D 1 33  VAL 33  33  33  VAL VAL R . 
D 1 34  ALA 34  34  34  ALA ALA R . 
D 1 35  VAL 35  35  35  VAL VAL R . 
D 1 36  VAL 36  36  36  VAL VAL R . 
D 1 37  ASP 37  37  37  ASP ASP R . 
D 1 38  MET 38  38  38  MET MET R . 
D 1 39  ASN 39  39  39  ASN ASN R . 
D 1 40  THR 40  40  40  THR THR R . 
D 1 41  ASP 41  41  41  ASP ASP R . 
D 1 42  ALA 42  42  42  ALA ALA R . 
D 1 43  ARG 43  43  43  ARG ARG R . 
D 1 44  TYR 44  44  44  TYR TYR R . 
D 1 45  PHE 45  45  45  PHE PHE R . 
D 1 46  ALA 46  46  46  ALA ALA R . 
D 1 47  TYR 47  47  47  TYR TYR R . 
D 1 48  GLN 48  48  48  GLN GLN R . 
D 1 49  MET 49  49  49  MET MET R . 
D 1 50  LYS 50  50  50  LYS LYS R . 
D 1 51  TYR 51  51  51  TYR TYR R . 
D 1 52  ASP 52  52  52  ASP ASP R . 
D 1 53  SER 53  53  53  SER SER R . 
D 1 54  VAL 54  54  54  VAL VAL R . 
D 1 55  HIS 55  55  55  HIS HIS R . 
D 1 56  GLY 56  56  56  GLY GLY R . 
D 1 57  LYS 57  57  57  LYS LYS R . 
D 1 58  PHE 58  58  58  PHE PHE R . 
D 1 59  LYS 59  59  59  LYS LYS R . 
D 1 60  HIS 60  60  60  HIS HIS R . 
D 1 61  SER 61  61  61  SER SER R . 
D 1 62  VAL 62  62  62  VAL VAL R . 
D 1 63  SER 63  63  63  SER SER R . 
D 1 64  THR 64  64  64  THR THR R . 
D 1 65  THR 65  65  65  THR THR R . 
D 1 66  LYS 66  66  66  LYS LYS R . 
D 1 67  SER 67  67  67  SER SER R . 
D 1 68  LYS 68  68  68  LYS LYS R . 
D 1 69  PRO 69  69  69  PRO PRO R . 
D 1 70  SER 70  70  70  SER SER R . 
D 1 71  VAL 71  71  71  VAL VAL R . 
D 1 72  ALA 72  72  72  ALA ALA R . 
D 1 73  LYS 73  73  73  LYS LYS R . 
D 1 74  ASP 74  74  74  ASP ASP R . 
D 1 75  ASP 75  75  75  ASP ASP R . 
D 1 76  THR 76  76  76  THR THR R . 
D 1 77  LEU 77  77  77  LEU LEU R . 
D 1 78  VAL 78  78  78  VAL VAL R . 
D 1 79  VAL 79  79  79  VAL VAL R . 
D 1 80  ASN 80  80  80  ASN ASN R . 
D 1 81  GLY 81  81  81  GLY GLY R . 
D 1 82  HIS 82  82  82  HIS HIS R . 
D 1 83  ARG 83  83  83  ARG ARG R . 
D 1 84  ILE 84  84  84  ILE ILE R . 
D 1 85  LEU 85  85  85  LEU LEU R . 
D 1 86  CYS 86  86  86  CYS CYS R . 
D 1 87  VAL 87  87  87  VAL VAL R . 
D 1 88  LYS 88  88  88  LYS LYS R . 
D 1 89  ALA 89  89  89  ALA ALA R . 
D 1 90  GLN 90  90  90  GLN GLN R . 
D 1 91  ARG 91  91  91  ARG ARG R . 
D 1 92  ASN 92  92  92  ASN ASN R . 
D 1 93  PRO 93  93  93  PRO PRO R . 
D 1 94  ALA 94  94  94  ALA ALA R . 
D 1 95  ASP 95  95  95  ASP ASP R . 
D 1 96  LEU 96  96  96  LEU LEU R . 
D 1 97  PRO 97  97  97  PRO PRO R . 
D 1 98  TRP 98  98  98  TRP TRP R . 
D 1 99  GLY 99  99  99  GLY GLY R . 
D 1 100 LYS 100 100 100 LYS LYS R . 
D 1 101 LEU 101 101 101 LEU LEU R . 
D 1 102 GLY 102 102 102 GLY GLY R . 
D 1 103 VAL 103 103 103 VAL VAL R . 
D 1 104 GLU 104 104 104 GLU GLU R . 
D 1 105 TYR 105 105 105 TYR TYR R . 
D 1 106 VAL 106 106 106 VAL VAL R . 
D 1 107 ILE 107 107 107 ILE ILE R . 
D 1 108 GLU 108 108 108 GLU GLU R . 
D 1 109 SER 109 109 109 SER SER R . 
D 1 110 THR 110 110 110 THR THR R . 
D 1 111 GLY 111 111 111 GLY GLY R . 
D 1 112 LEU 112 112 112 LEU LEU R . 
D 1 113 PHE 113 113 113 PHE PHE R . 
D 1 114 THR 114 114 114 THR THR R . 
D 1 115 VAL 115 115 115 VAL VAL R . 
D 1 116 LYS 116 116 116 LYS LYS R . 
D 1 117 SER 117 117 117 SER SER R . 
D 1 118 ALA 118 118 118 ALA ALA R . 
D 1 119 ALA 119 119 119 ALA ALA R . 
D 1 120 GLU 120 120 120 GLU GLU R . 
D 1 121 GLY 121 121 121 GLY GLY R . 
D 1 122 HIS 122 122 122 HIS HIS R . 
D 1 123 LEU 123 123 123 LEU LEU R . 
D 1 124 ARG 124 124 124 ARG ARG R . 
D 1 125 GLY 125 125 125 GLY GLY R . 
D 1 126 GLY 126 126 126 GLY GLY R . 
D 1 127 ALA 127 127 127 ALA ALA R . 
D 1 128 ARG 128 128 128 ARG ARG R . 
D 1 129 LYS 129 129 129 LYS LYS R . 
D 1 130 VAL 130 130 130 VAL VAL R . 
D 1 131 VAL 131 131 131 VAL VAL R . 
D 1 132 ILE 132 132 132 ILE ILE R . 
D 1 133 SER 133 133 133 SER SER R . 
D 1 134 ALA 134 134 134 ALA ALA R . 
D 1 135 PRO 135 135 135 PRO PRO R . 
D 1 136 ALA 136 136 136 ALA ALA R . 
D 1 137 SER 137 137 137 SER SER R . 
D 1 138 GLY 138 138 138 GLY GLY R . 
D 1 139 GLY 139 139 139 GLY GLY R . 
D 1 140 ALA 140 140 140 ALA ALA R . 
D 1 141 LYS 141 141 141 LYS LYS R . 
D 1 142 THR 142 142 142 THR THR R . 
D 1 143 PHE 143 143 143 PHE PHE R . 
D 1 144 VAL 144 144 144 VAL VAL R . 
D 1 145 MET 145 145 145 MET MET R . 
D 1 146 GLY 146 146 146 GLY GLY R . 
D 1 147 VAL 147 147 147 VAL VAL R . 
D 1 148 ASN 148 148 148 ASN ASN R . 
D 1 149 HIS 149 149 149 HIS HIS R . 
D 1 150 ASN 150 150 150 ASN ASN R . 
D 1 151 ASN 151 151 151 ASN ASN R . 
D 1 152 TYR 152 152 152 TYR TYR R . 
D 1 153 ASN 153 153 153 ASN ASN R . 
D 1 154 PRO 154 154 154 PRO PRO R . 
D 1 155 ARG 155 155 155 ARG ARG R . 
D 1 156 GLU 156 156 156 GLU GLU R . 
D 1 157 GLN 157 157 157 GLN GLN R . 
D 1 158 HIS 158 158 158 HIS HIS R . 
D 1 159 VAL 159 159 159 VAL VAL R . 
D 1 160 VAL 160 160 160 VAL VAL R . 
D 1 161 SER 161 161 161 SER SER R . 
D 1 162 ASN 162 162 162 ASN ASN R . 
D 1 163 ALA 163 163 163 ALA ALA R . 
D 1 164 SER 164 164 164 SER SER R . 
D 1 165 CYS 165 165 165 CYS CYS R . 
D 1 166 THR 166 166 166 THR THR R . 
D 1 167 THR 167 167 167 THR THR R . 
D 1 168 ASN 168 168 168 ASN ASN R . 
D 1 169 CYS 169 169 169 CYS CYS R . 
D 1 170 LEU 170 170 170 LEU LEU R . 
D 1 171 ALA 171 171 171 ALA ALA R . 
D 1 172 PRO 172 172 172 PRO PRO R . 
D 1 173 LEU 173 173 173 LEU LEU R . 
D 1 174 VAL 174 174 174 VAL VAL R . 
D 1 175 HIS 175 175 175 HIS HIS R . 
D 1 176 VAL 176 176 176 VAL VAL R . 
D 1 177 LEU 177 177 177 LEU LEU R . 
D 1 178 VAL 178 178 178 VAL VAL R . 
D 1 179 LYS 179 179 179 LYS LYS R . 
D 1 180 GLU 180 180 180 GLU GLU R . 
D 1 181 GLY 181 181 181 GLY GLY R . 
D 1 182 PHE 182 182 182 PHE PHE R . 
D 1 183 GLY 183 183 183 GLY GLY R . 
D 1 184 ILE 184 184 184 ILE ILE R . 
D 1 185 SER 185 185 185 SER SER R . 
D 1 186 THR 186 186 186 THR THR R . 
D 1 187 GLY 187 187 187 GLY GLY R . 
D 1 188 LEU 188 188 188 LEU LEU R . 
D 1 189 MET 189 189 189 MET MET R . 
D 1 190 THR 190 190 190 THR THR R . 
D 1 191 THR 191 191 191 THR THR R . 
D 1 192 VAL 192 192 192 VAL VAL R . 
D 1 193 HIS 193 193 193 HIS HIS R . 
D 1 194 SER 194 194 194 SER SER R . 
D 1 195 TYR 195 195 195 TYR TYR R . 
D 1 196 THR 196 196 196 THR THR R . 
D 1 197 ALA 197 197 197 ALA ALA R . 
D 1 198 THR 198 198 198 THR THR R . 
D 1 199 GLN 199 199 199 GLN GLN R . 
D 1 200 LYS 200 200 200 LYS LYS R . 
D 1 201 THR 201 201 201 THR THR R . 
D 1 202 VAL 202 202 202 VAL VAL R . 
D 1 203 ASP 203 203 203 ASP ASP R . 
D 1 204 GLY 204 204 204 GLY GLY R . 
D 1 205 VAL 205 205 205 VAL VAL R . 
D 1 206 SER 206 206 206 SER SER R . 
D 1 207 VAL 207 207 207 VAL VAL R . 
D 1 208 LYS 208 208 208 LYS LYS R . 
D 1 209 ASP 209 209 209 ASP ASP R . 
D 1 210 TRP 210 210 210 TRP TRP R . 
D 1 211 ARG 211 211 211 ARG ARG R . 
D 1 212 GLY 212 212 212 GLY GLY R . 
D 1 213 GLY 213 213 213 GLY GLY R . 
D 1 214 ARG 214 214 214 ARG ARG R . 
D 1 215 ALA 215 215 215 ALA ALA R . 
D 1 216 ALA 216 216 216 ALA ALA R . 
D 1 217 ALA 217 217 217 ALA ALA R . 
D 1 218 LEU 218 218 218 LEU LEU R . 
D 1 219 ASN 219 219 219 ASN ASN R . 
D 1 220 ILE 220 220 220 ILE ILE R . 
D 1 221 ILE 221 221 221 ILE ILE R . 
D 1 222 PRO 222 222 222 PRO PRO R . 
D 1 223 SER 223 223 223 SER SER R . 
D 1 224 THR 224 224 224 THR THR R . 
D 1 225 THR 225 225 225 THR THR R . 
D 1 226 GLY 226 226 226 GLY GLY R . 
D 1 227 ALA 227 227 227 ALA ALA R . 
D 1 228 ALA 228 228 228 ALA ALA R . 
D 1 229 LYS 229 229 229 LYS LYS R . 
D 1 230 ALA 230 230 230 ALA ALA R . 
D 1 231 VAL 231 231 231 VAL VAL R . 
D 1 232 GLY 232 232 232 GLY GLY R . 
D 1 233 MET 233 233 233 MET MET R . 
D 1 234 VAL 234 234 234 VAL VAL R . 
D 1 235 ILE 235 235 235 ILE ILE R . 
D 1 236 PRO 236 236 236 PRO PRO R . 
D 1 237 SER 237 237 237 SER SER R . 
D 1 238 THR 238 238 238 THR THR R . 
D 1 239 GLN 239 239 239 GLN GLN R . 
D 1 240 GLY 240 240 240 GLY GLY R . 
D 1 241 LYS 241 241 241 LYS LYS R . 
D 1 242 LEU 242 242 242 LEU LEU R . 
D 1 243 THR 243 243 243 THR THR R . 
D 1 244 GLY 244 244 244 GLY GLY R . 
D 1 245 MET 245 245 245 MET MET R . 
D 1 246 ALA 246 246 246 ALA ALA R . 
D 1 247 PHE 247 247 247 PHE PHE R . 
D 1 248 ARG 248 248 248 ARG ARG R . 
D 1 249 VAL 249 249 249 VAL VAL R . 
D 1 250 PRO 250 250 250 PRO PRO R . 
D 1 251 THR 251 251 251 THR THR R . 
D 1 252 ALA 252 252 252 ALA ALA R . 
D 1 253 ASP 253 253 253 ASP ASP R . 
D 1 254 VAL 254 254 254 VAL VAL R . 
D 1 255 SER 255 255 255 SER SER R . 
D 1 256 VAL 256 256 256 VAL VAL R . 
D 1 257 VAL 257 257 257 VAL VAL R . 
D 1 258 ASP 258 258 258 ASP ASP R . 
D 1 259 LEU 259 259 259 LEU LEU R . 
D 1 260 THR 260 260 260 THR THR R . 
D 1 261 PHE 261 261 261 PHE PHE R . 
D 1 262 ILE 262 262 262 ILE ILE R . 
D 1 263 ALA 263 263 263 ALA ALA R . 
D 1 264 THR 264 264 264 THR THR R . 
D 1 265 ARG 265 265 265 ARG ARG R . 
D 1 266 ASP 266 266 266 ASP ASP R . 
D 1 267 THR 267 267 267 THR THR R . 
D 1 268 SER 268 268 268 SER SER R . 
D 1 269 ILE 269 269 269 ILE ILE R . 
D 1 270 LYS 270 270 270 LYS LYS R . 
D 1 271 GLU 271 271 271 GLU GLU R . 
D 1 272 ILE 272 272 272 ILE ILE R . 
D 1 273 ASP 273 273 273 ASP ASP R . 
D 1 274 ALA 274 274 274 ALA ALA R . 
D 1 275 ALA 275 275 275 ALA ALA R . 
D 1 276 LEU 276 276 276 LEU LEU R . 
D 1 277 LYS 277 277 277 LYS LYS R . 
D 1 278 ARG 278 278 278 ARG ARG R . 
D 1 279 ALA 279 279 279 ALA ALA R . 
D 1 280 SER 280 280 280 SER SER R . 
D 1 281 LYS 281 281 281 LYS LYS R . 
D 1 282 THR 282 282 282 THR THR R . 
D 1 283 TYR 283 283 283 TYR TYR R . 
D 1 284 MET 284 284 284 MET MET R . 
D 1 285 LYS 285 285 285 LYS LYS R . 
D 1 286 ASN 286 286 286 ASN ASN R . 
D 1 287 ILE 287 287 287 ILE ILE R . 
D 1 288 LEU 288 288 288 LEU LEU R . 
D 1 289 GLY 289 289 289 GLY GLY R . 
D 1 290 TYR 290 290 290 TYR TYR R . 
D 1 291 THR 291 291 291 THR THR R . 
D 1 292 ASP 292 292 292 ASP ASP R . 
D 1 293 GLU 293 293 293 GLU GLU R . 
D 1 294 GLU 294 294 294 GLU GLU R . 
D 1 295 LEU 295 295 295 LEU LEU R . 
D 1 296 VAL 296 296 296 VAL VAL R . 
D 1 297 SER 297 297 297 SER SER R . 
D 1 298 ALA 298 298 298 ALA ALA R . 
D 1 299 ASP 299 299 299 ASP ASP R . 
D 1 300 PHE 300 300 300 PHE PHE R . 
D 1 301 ILE 301 301 301 ILE ILE R . 
D 1 302 SER 302 302 302 SER SER R . 
D 1 303 ASP 303 303 303 ASP ASP R . 
D 1 304 SER 304 304 304 SER SER R . 
D 1 305 ARG 305 305 305 ARG ARG R . 
D 1 306 SER 306 306 306 SER SER R . 
D 1 307 SER 307 307 307 SER SER R . 
D 1 308 ILE 308 308 308 ILE ILE R . 
D 1 309 TYR 309 309 309 TYR TYR R . 
D 1 310 ASP 310 310 310 ASP ASP R . 
D 1 311 SER 311 311 311 SER SER R . 
D 1 312 LYS 312 312 312 LYS LYS R . 
D 1 313 ALA 313 313 313 ALA ALA R . 
D 1 314 THR 314 314 314 THR THR R . 
D 1 315 LEU 315 315 315 LEU LEU R . 
D 1 316 GLN 316 316 316 GLN GLN R . 
D 1 317 ASN 317 317 317 ASN ASN R . 
D 1 318 ASN 318 318 318 ASN ASN R . 
D 1 319 LEU 319 319 319 LEU LEU R . 
D 1 320 PRO 320 320 320 PRO PRO R . 
D 1 321 ASN 321 321 321 ASN ASN R . 
D 1 322 GLU 322 322 322 GLU GLU R . 
D 1 323 ARG 323 323 323 ARG ARG R . 
D 1 324 ARG 324 324 324 ARG ARG R . 
D 1 325 PHE 325 325 325 PHE PHE R . 
D 1 326 PHE 326 326 326 PHE PHE R . 
D 1 327 LYS 327 327 327 LYS LYS R . 
D 1 328 ILE 328 328 328 ILE ILE R . 
D 1 329 VAL 329 329 329 VAL VAL R . 
D 1 330 SER 330 330 330 SER SER R . 
D 1 331 TRP 331 331 331 TRP TRP R . 
D 1 332 TYR 332 332 332 TYR TYR R . 
D 1 333 ASP 333 333 333 ASP ASP R . 
D 1 334 ASN 334 334 334 ASN ASN R . 
D 1 335 GLU 335 335 335 GLU GLU R . 
D 1 336 TRP 336 336 336 TRP TRP R . 
D 1 337 GLY 337 337 337 GLY GLY R . 
D 1 338 TYR 338 338 338 TYR TYR R . 
D 1 339 SER 339 339 339 SER SER R . 
D 1 340 HIS 340 340 340 HIS HIS R . 
D 1 341 ARG 341 341 341 ARG ARG R . 
D 1 342 VAL 342 342 342 VAL VAL R . 
D 1 343 VAL 343 343 343 VAL VAL R . 
D 1 344 ASP 344 344 344 ASP ASP R . 
D 1 345 LEU 345 345 345 LEU LEU R . 
D 1 346 VAL 346 346 346 VAL VAL R . 
D 1 347 ARG 347 347 347 ARG ARG R . 
D 1 348 HIS 348 348 348 HIS HIS R . 
D 1 349 MET 349 349 349 MET MET R . 
D 1 350 ALA 350 350 350 ALA ALA R . 
D 1 351 ALA 351 351 351 ALA ALA R . 
D 1 352 ARG 352 352 352 ARG ARG R . 
D 1 353 ASP 353 353 353 ASP ASP R . 
D 1 354 ARG 354 354 354 ARG ARG R . 
D 1 355 ALA 355 355 355 ALA ALA R . 
D 1 356 ALA 356 356 356 ALA ALA R . 
D 1 357 LYS 357 357 357 LYS LYS R . 
D 1 358 LEU 358 358 358 LEU LEU R . 
E 1 1   THR 1   1   1   THR THR A . 
E 1 2   ILE 2   2   2   ILE ILE A . 
E 1 3   LYS 3   3   3   LYS LYS A . 
E 1 4   VAL 4   4   4   VAL VAL A . 
E 1 5   GLY 5   5   5   GLY GLY A . 
E 1 6   ILE 6   6   6   ILE ILE A . 
E 1 7   ASN 7   7   7   ASN ASN A . 
E 1 8   GLY 8   8   8   GLY GLY A . 
E 1 9   PHE 9   9   9   PHE PHE A . 
E 1 10  GLY 10  10  10  GLY GLY A . 
E 1 11  ARG 11  11  11  ARG ARG A . 
E 1 12  ILE 12  12  12  ILE ILE A . 
E 1 13  GLY 13  13  13  GLY GLY A . 
E 1 14  ARG 14  14  14  ARG ARG A . 
E 1 15  MET 15  15  15  MET MET A . 
E 1 16  VAL 16  16  16  VAL VAL A . 
E 1 17  PHE 17  17  17  PHE PHE A . 
E 1 18  GLN 18  18  18  GLN GLN A . 
E 1 19  ALA 19  19  19  ALA ALA A . 
E 1 20  LEU 20  20  20  LEU LEU A . 
E 1 21  CYS 21  21  21  CYS CYS A . 
E 1 22  ASP 22  22  22  ASP ASP A . 
E 1 23  ASP 23  23  23  ASP ASP A . 
E 1 24  GLY 24  24  24  GLY GLY A . 
E 1 25  LEU 25  25  25  LEU LEU A . 
E 1 26  LEU 26  26  26  LEU LEU A . 
E 1 27  GLY 27  27  27  GLY GLY A . 
E 1 28  ASN 28  28  28  ASN ASN A . 
E 1 29  GLU 29  29  29  GLU GLU A . 
E 1 30  ILE 30  30  30  ILE ILE A . 
E 1 31  ASP 31  31  31  ASP ASP A . 
E 1 32  VAL 32  32  32  VAL VAL A . 
E 1 33  VAL 33  33  33  VAL VAL A . 
E 1 34  ALA 34  34  34  ALA ALA A . 
E 1 35  VAL 35  35  35  VAL VAL A . 
E 1 36  VAL 36  36  36  VAL VAL A . 
E 1 37  ASP 37  37  37  ASP ASP A . 
E 1 38  MET 38  38  38  MET MET A . 
E 1 39  ASN 39  39  39  ASN ASN A . 
E 1 40  THR 40  40  40  THR THR A . 
E 1 41  ASP 41  41  41  ASP ASP A . 
E 1 42  ALA 42  42  42  ALA ALA A . 
E 1 43  ARG 43  43  43  ARG ARG A . 
E 1 44  TYR 44  44  44  TYR TYR A . 
E 1 45  PHE 45  45  45  PHE PHE A . 
E 1 46  ALA 46  46  46  ALA ALA A . 
E 1 47  TYR 47  47  47  TYR TYR A . 
E 1 48  GLN 48  48  48  GLN GLN A . 
E 1 49  MET 49  49  49  MET MET A . 
E 1 50  LYS 50  50  50  LYS LYS A . 
E 1 51  TYR 51  51  51  TYR TYR A . 
E 1 52  ASP 52  52  52  ASP ASP A . 
E 1 53  SER 53  53  53  SER SER A . 
E 1 54  VAL 54  54  54  VAL VAL A . 
E 1 55  HIS 55  55  55  HIS HIS A . 
E 1 56  GLY 56  56  56  GLY GLY A . 
E 1 57  LYS 57  57  57  LYS LYS A . 
E 1 58  PHE 58  58  58  PHE PHE A . 
E 1 59  LYS 59  59  59  LYS LYS A . 
E 1 60  HIS 60  60  60  HIS HIS A . 
E 1 61  SER 61  61  61  SER SER A . 
E 1 62  VAL 62  62  62  VAL VAL A . 
E 1 63  SER 63  63  63  SER SER A . 
E 1 64  THR 64  64  64  THR THR A . 
E 1 65  THR 65  65  65  THR THR A . 
E 1 66  LYS 66  66  66  LYS LYS A . 
E 1 67  SER 67  67  67  SER SER A . 
E 1 68  LYS 68  68  68  LYS LYS A . 
E 1 69  PRO 69  69  69  PRO PRO A . 
E 1 70  SER 70  70  70  SER SER A . 
E 1 71  VAL 71  71  71  VAL VAL A . 
E 1 72  ALA 72  72  72  ALA ALA A . 
E 1 73  LYS 73  73  73  LYS LYS A . 
E 1 74  ASP 74  74  74  ASP ASP A . 
E 1 75  ASP 75  75  75  ASP ASP A . 
E 1 76  THR 76  76  76  THR THR A . 
E 1 77  LEU 77  77  77  LEU LEU A . 
E 1 78  VAL 78  78  78  VAL VAL A . 
E 1 79  VAL 79  79  79  VAL VAL A . 
E 1 80  ASN 80  80  80  ASN ASN A . 
E 1 81  GLY 81  81  81  GLY GLY A . 
E 1 82  HIS 82  82  82  HIS HIS A . 
E 1 83  ARG 83  83  83  ARG ARG A . 
E 1 84  ILE 84  84  84  ILE ILE A . 
E 1 85  LEU 85  85  85  LEU LEU A . 
E 1 86  CYS 86  86  86  CYS CYS A . 
E 1 87  VAL 87  87  87  VAL VAL A . 
E 1 88  LYS 88  88  88  LYS LYS A . 
E 1 89  ALA 89  89  89  ALA ALA A . 
E 1 90  GLN 90  90  90  GLN GLN A . 
E 1 91  ARG 91  91  91  ARG ARG A . 
E 1 92  ASN 92  92  92  ASN ASN A . 
E 1 93  PRO 93  93  93  PRO PRO A . 
E 1 94  ALA 94  94  94  ALA ALA A . 
E 1 95  ASP 95  95  95  ASP ASP A . 
E 1 96  LEU 96  96  96  LEU LEU A . 
E 1 97  PRO 97  97  97  PRO PRO A . 
E 1 98  TRP 98  98  98  TRP TRP A . 
E 1 99  GLY 99  99  99  GLY GLY A . 
E 1 100 LYS 100 100 100 LYS LYS A . 
E 1 101 LEU 101 101 101 LEU LEU A . 
E 1 102 GLY 102 102 102 GLY GLY A . 
E 1 103 VAL 103 103 103 VAL VAL A . 
E 1 104 GLU 104 104 104 GLU GLU A . 
E 1 105 TYR 105 105 105 TYR TYR A . 
E 1 106 VAL 106 106 106 VAL VAL A . 
E 1 107 ILE 107 107 107 ILE ILE A . 
E 1 108 GLU 108 108 108 GLU GLU A . 
E 1 109 SER 109 109 109 SER SER A . 
E 1 110 THR 110 110 110 THR THR A . 
E 1 111 GLY 111 111 111 GLY GLY A . 
E 1 112 LEU 112 112 112 LEU LEU A . 
E 1 113 PHE 113 113 113 PHE PHE A . 
E 1 114 THR 114 114 114 THR THR A . 
E 1 115 VAL 115 115 115 VAL VAL A . 
E 1 116 LYS 116 116 116 LYS LYS A . 
E 1 117 SER 117 117 117 SER SER A . 
E 1 118 ALA 118 118 118 ALA ALA A . 
E 1 119 ALA 119 119 119 ALA ALA A . 
E 1 120 GLU 120 120 120 GLU GLU A . 
E 1 121 GLY 121 121 121 GLY GLY A . 
E 1 122 HIS 122 122 122 HIS HIS A . 
E 1 123 LEU 123 123 123 LEU LEU A . 
E 1 124 ARG 124 124 124 ARG ARG A . 
E 1 125 GLY 125 125 125 GLY GLY A . 
E 1 126 GLY 126 126 126 GLY GLY A . 
E 1 127 ALA 127 127 127 ALA ALA A . 
E 1 128 ARG 128 128 128 ARG ARG A . 
E 1 129 LYS 129 129 129 LYS LYS A . 
E 1 130 VAL 130 130 130 VAL VAL A . 
E 1 131 VAL 131 131 131 VAL VAL A . 
E 1 132 ILE 132 132 132 ILE ILE A . 
E 1 133 SER 133 133 133 SER SER A . 
E 1 134 ALA 134 134 134 ALA ALA A . 
E 1 135 PRO 135 135 135 PRO PRO A . 
E 1 136 ALA 136 136 136 ALA ALA A . 
E 1 137 SER 137 137 137 SER SER A . 
E 1 138 GLY 138 138 138 GLY GLY A . 
E 1 139 GLY 139 139 139 GLY GLY A . 
E 1 140 ALA 140 140 140 ALA ALA A . 
E 1 141 LYS 141 141 141 LYS LYS A . 
E 1 142 THR 142 142 142 THR THR A . 
E 1 143 PHE 143 143 143 PHE PHE A . 
E 1 144 VAL 144 144 144 VAL VAL A . 
E 1 145 MET 145 145 145 MET MET A . 
E 1 146 GLY 146 146 146 GLY GLY A . 
E 1 147 VAL 147 147 147 VAL VAL A . 
E 1 148 ASN 148 148 148 ASN ASN A . 
E 1 149 HIS 149 149 149 HIS HIS A . 
E 1 150 ASN 150 150 150 ASN ASN A . 
E 1 151 ASN 151 151 151 ASN ASN A . 
E 1 152 TYR 152 152 152 TYR TYR A . 
E 1 153 ASN 153 153 153 ASN ASN A . 
E 1 154 PRO 154 154 154 PRO PRO A . 
E 1 155 ARG 155 155 155 ARG ARG A . 
E 1 156 GLU 156 156 156 GLU GLU A . 
E 1 157 GLN 157 157 157 GLN GLN A . 
E 1 158 HIS 158 158 158 HIS HIS A . 
E 1 159 VAL 159 159 159 VAL VAL A . 
E 1 160 VAL 160 160 160 VAL VAL A . 
E 1 161 SER 161 161 161 SER SER A . 
E 1 162 ASN 162 162 162 ASN ASN A . 
E 1 163 ALA 163 163 163 ALA ALA A . 
E 1 164 SER 164 164 164 SER SER A . 
E 1 165 CYS 165 165 165 CYS CYS A . 
E 1 166 THR 166 166 166 THR THR A . 
E 1 167 THR 167 167 167 THR THR A . 
E 1 168 ASN 168 168 168 ASN ASN A . 
E 1 169 CYS 169 169 169 CYS CYS A . 
E 1 170 LEU 170 170 170 LEU LEU A . 
E 1 171 ALA 171 171 171 ALA ALA A . 
E 1 172 PRO 172 172 172 PRO PRO A . 
E 1 173 LEU 173 173 173 LEU LEU A . 
E 1 174 VAL 174 174 174 VAL VAL A . 
E 1 175 HIS 175 175 175 HIS HIS A . 
E 1 176 VAL 176 176 176 VAL VAL A . 
E 1 177 LEU 177 177 177 LEU LEU A . 
E 1 178 VAL 178 178 178 VAL VAL A . 
E 1 179 LYS 179 179 179 LYS LYS A . 
E 1 180 GLU 180 180 180 GLU GLU A . 
E 1 181 GLY 181 181 181 GLY GLY A . 
E 1 182 PHE 182 182 182 PHE PHE A . 
E 1 183 GLY 183 183 183 GLY GLY A . 
E 1 184 ILE 184 184 184 ILE ILE A . 
E 1 185 SER 185 185 185 SER SER A . 
E 1 186 THR 186 186 186 THR THR A . 
E 1 187 GLY 187 187 187 GLY GLY A . 
E 1 188 LEU 188 188 188 LEU LEU A . 
E 1 189 MET 189 189 189 MET MET A . 
E 1 190 THR 190 190 190 THR THR A . 
E 1 191 THR 191 191 191 THR THR A . 
E 1 192 VAL 192 192 192 VAL VAL A . 
E 1 193 HIS 193 193 193 HIS HIS A . 
E 1 194 SER 194 194 194 SER SER A . 
E 1 195 TYR 195 195 195 TYR TYR A . 
E 1 196 THR 196 196 196 THR THR A . 
E 1 197 ALA 197 197 197 ALA ALA A . 
E 1 198 THR 198 198 198 THR THR A . 
E 1 199 GLN 199 199 199 GLN GLN A . 
E 1 200 LYS 200 200 200 LYS LYS A . 
E 1 201 THR 201 201 201 THR THR A . 
E 1 202 VAL 202 202 202 VAL VAL A . 
E 1 203 ASP 203 203 203 ASP ASP A . 
E 1 204 GLY 204 204 204 GLY GLY A . 
E 1 205 VAL 205 205 205 VAL VAL A . 
E 1 206 SER 206 206 206 SER SER A . 
E 1 207 VAL 207 207 207 VAL VAL A . 
E 1 208 LYS 208 208 208 LYS LYS A . 
E 1 209 ASP 209 209 209 ASP ASP A . 
E 1 210 TRP 210 210 210 TRP TRP A . 
E 1 211 ARG 211 211 211 ARG ARG A . 
E 1 212 GLY 212 212 212 GLY GLY A . 
E 1 213 GLY 213 213 213 GLY GLY A . 
E 1 214 ARG 214 214 214 ARG ARG A . 
E 1 215 ALA 215 215 215 ALA ALA A . 
E 1 216 ALA 216 216 216 ALA ALA A . 
E 1 217 ALA 217 217 217 ALA ALA A . 
E 1 218 LEU 218 218 218 LEU LEU A . 
E 1 219 ASN 219 219 219 ASN ASN A . 
E 1 220 ILE 220 220 220 ILE ILE A . 
E 1 221 ILE 221 221 221 ILE ILE A . 
E 1 222 PRO 222 222 222 PRO PRO A . 
E 1 223 SER 223 223 223 SER SER A . 
E 1 224 THR 224 224 224 THR THR A . 
E 1 225 THR 225 225 225 THR THR A . 
E 1 226 GLY 226 226 226 GLY GLY A . 
E 1 227 ALA 227 227 227 ALA ALA A . 
E 1 228 ALA 228 228 228 ALA ALA A . 
E 1 229 LYS 229 229 229 LYS LYS A . 
E 1 230 ALA 230 230 230 ALA ALA A . 
E 1 231 VAL 231 231 231 VAL VAL A . 
E 1 232 GLY 232 232 232 GLY GLY A . 
E 1 233 MET 233 233 233 MET MET A . 
E 1 234 VAL 234 234 234 VAL VAL A . 
E 1 235 ILE 235 235 235 ILE ILE A . 
E 1 236 PRO 236 236 236 PRO PRO A . 
E 1 237 SER 237 237 237 SER SER A . 
E 1 238 THR 238 238 238 THR THR A . 
E 1 239 GLN 239 239 239 GLN GLN A . 
E 1 240 GLY 240 240 240 GLY GLY A . 
E 1 241 LYS 241 241 241 LYS LYS A . 
E 1 242 LEU 242 242 242 LEU LEU A . 
E 1 243 THR 243 243 243 THR THR A . 
E 1 244 GLY 244 244 244 GLY GLY A . 
E 1 245 MET 245 245 245 MET MET A . 
E 1 246 ALA 246 246 246 ALA ALA A . 
E 1 247 PHE 247 247 247 PHE PHE A . 
E 1 248 ARG 248 248 248 ARG ARG A . 
E 1 249 VAL 249 249 249 VAL VAL A . 
E 1 250 PRO 250 250 250 PRO PRO A . 
E 1 251 THR 251 251 251 THR THR A . 
E 1 252 ALA 252 252 252 ALA ALA A . 
E 1 253 ASP 253 253 253 ASP ASP A . 
E 1 254 VAL 254 254 254 VAL VAL A . 
E 1 255 SER 255 255 255 SER SER A . 
E 1 256 VAL 256 256 256 VAL VAL A . 
E 1 257 VAL 257 257 257 VAL VAL A . 
E 1 258 ASP 258 258 258 ASP ASP A . 
E 1 259 LEU 259 259 259 LEU LEU A . 
E 1 260 THR 260 260 260 THR THR A . 
E 1 261 PHE 261 261 261 PHE PHE A . 
E 1 262 ILE 262 262 262 ILE ILE A . 
E 1 263 ALA 263 263 263 ALA ALA A . 
E 1 264 THR 264 264 264 THR THR A . 
E 1 265 ARG 265 265 265 ARG ARG A . 
E 1 266 ASP 266 266 266 ASP ASP A . 
E 1 267 THR 267 267 267 THR THR A . 
E 1 268 SER 268 268 268 SER SER A . 
E 1 269 ILE 269 269 269 ILE ILE A . 
E 1 270 LYS 270 270 270 LYS LYS A . 
E 1 271 GLU 271 271 271 GLU GLU A . 
E 1 272 ILE 272 272 272 ILE ILE A . 
E 1 273 ASP 273 273 273 ASP ASP A . 
E 1 274 ALA 274 274 274 ALA ALA A . 
E 1 275 ALA 275 275 275 ALA ALA A . 
E 1 276 LEU 276 276 276 LEU LEU A . 
E 1 277 LYS 277 277 277 LYS LYS A . 
E 1 278 ARG 278 278 278 ARG ARG A . 
E 1 279 ALA 279 279 279 ALA ALA A . 
E 1 280 SER 280 280 280 SER SER A . 
E 1 281 LYS 281 281 281 LYS LYS A . 
E 1 282 THR 282 282 282 THR THR A . 
E 1 283 TYR 283 283 283 TYR TYR A . 
E 1 284 MET 284 284 284 MET MET A . 
E 1 285 LYS 285 285 285 LYS LYS A . 
E 1 286 ASN 286 286 286 ASN ASN A . 
E 1 287 ILE 287 287 287 ILE ILE A . 
E 1 288 LEU 288 288 288 LEU LEU A . 
E 1 289 GLY 289 289 289 GLY GLY A . 
E 1 290 TYR 290 290 290 TYR TYR A . 
E 1 291 THR 291 291 291 THR THR A . 
E 1 292 ASP 292 292 292 ASP ASP A . 
E 1 293 GLU 293 293 293 GLU GLU A . 
E 1 294 GLU 294 294 294 GLU GLU A . 
E 1 295 LEU 295 295 295 LEU LEU A . 
E 1 296 VAL 296 296 296 VAL VAL A . 
E 1 297 SER 297 297 297 SER SER A . 
E 1 298 ALA 298 298 298 ALA ALA A . 
E 1 299 ASP 299 299 299 ASP ASP A . 
E 1 300 PHE 300 300 300 PHE PHE A . 
E 1 301 ILE 301 301 301 ILE ILE A . 
E 1 302 SER 302 302 302 SER SER A . 
E 1 303 ASP 303 303 303 ASP ASP A . 
E 1 304 SER 304 304 304 SER SER A . 
E 1 305 ARG 305 305 305 ARG ARG A . 
E 1 306 SER 306 306 306 SER SER A . 
E 1 307 SER 307 307 307 SER SER A . 
E 1 308 ILE 308 308 308 ILE ILE A . 
E 1 309 TYR 309 309 309 TYR TYR A . 
E 1 310 ASP 310 310 310 ASP ASP A . 
E 1 311 SER 311 311 311 SER SER A . 
E 1 312 LYS 312 312 312 LYS LYS A . 
E 1 313 ALA 313 313 313 ALA ALA A . 
E 1 314 THR 314 314 314 THR THR A . 
E 1 315 LEU 315 315 315 LEU LEU A . 
E 1 316 GLN 316 316 316 GLN GLN A . 
E 1 317 ASN 317 317 317 ASN ASN A . 
E 1 318 ASN 318 318 318 ASN ASN A . 
E 1 319 LEU 319 319 319 LEU LEU A . 
E 1 320 PRO 320 320 320 PRO PRO A . 
E 1 321 ASN 321 321 321 ASN ASN A . 
E 1 322 GLU 322 322 322 GLU GLU A . 
E 1 323 ARG 323 323 323 ARG ARG A . 
E 1 324 ARG 324 324 324 ARG ARG A . 
E 1 325 PHE 325 325 325 PHE PHE A . 
E 1 326 PHE 326 326 326 PHE PHE A . 
E 1 327 LYS 327 327 327 LYS LYS A . 
E 1 328 ILE 328 328 328 ILE ILE A . 
E 1 329 VAL 329 329 329 VAL VAL A . 
E 1 330 SER 330 330 330 SER SER A . 
E 1 331 TRP 331 331 331 TRP TRP A . 
E 1 332 TYR 332 332 332 TYR TYR A . 
E 1 333 ASP 333 333 333 ASP ASP A . 
E 1 334 ASN 334 334 334 ASN ASN A . 
E 1 335 GLU 335 335 335 GLU GLU A . 
E 1 336 TRP 336 336 336 TRP TRP A . 
E 1 337 GLY 337 337 337 GLY GLY A . 
E 1 338 TYR 338 338 338 TYR TYR A . 
E 1 339 SER 339 339 339 SER SER A . 
E 1 340 HIS 340 340 340 HIS HIS A . 
E 1 341 ARG 341 341 341 ARG ARG A . 
E 1 342 VAL 342 342 342 VAL VAL A . 
E 1 343 VAL 343 343 343 VAL VAL A . 
E 1 344 ASP 344 344 344 ASP ASP A . 
E 1 345 LEU 345 345 345 LEU LEU A . 
E 1 346 VAL 346 346 346 VAL VAL A . 
E 1 347 ARG 347 347 347 ARG ARG A . 
E 1 348 HIS 348 348 348 HIS HIS A . 
E 1 349 MET 349 349 349 MET MET A . 
E 1 350 ALA 350 350 350 ALA ALA A . 
E 1 351 ALA 351 351 351 ALA ALA A . 
E 1 352 ARG 352 352 352 ARG ARG A . 
E 1 353 ASP 353 353 353 ASP ASP A . 
E 1 354 ARG 354 354 354 ARG ARG A . 
E 1 355 ALA 355 355 355 ALA ALA A . 
E 1 356 ALA 356 356 356 ALA ALA A . 
E 1 357 LYS 357 357 357 LYS LYS A . 
E 1 358 LEU 358 358 358 LEU LEU A . 
G 1 1   THR 1   1   1   THR THR B . 
G 1 2   ILE 2   2   2   ILE ILE B . 
G 1 3   LYS 3   3   3   LYS LYS B . 
G 1 4   VAL 4   4   4   VAL VAL B . 
G 1 5   GLY 5   5   5   GLY GLY B . 
G 1 6   ILE 6   6   6   ILE ILE B . 
G 1 7   ASN 7   7   7   ASN ASN B . 
G 1 8   GLY 8   8   8   GLY GLY B . 
G 1 9   PHE 9   9   9   PHE PHE B . 
G 1 10  GLY 10  10  10  GLY GLY B . 
G 1 11  ARG 11  11  11  ARG ARG B . 
G 1 12  ILE 12  12  12  ILE ILE B . 
G 1 13  GLY 13  13  13  GLY GLY B . 
G 1 14  ARG 14  14  14  ARG ARG B . 
G 1 15  MET 15  15  15  MET MET B . 
G 1 16  VAL 16  16  16  VAL VAL B . 
G 1 17  PHE 17  17  17  PHE PHE B . 
G 1 18  GLN 18  18  18  GLN GLN B . 
G 1 19  ALA 19  19  19  ALA ALA B . 
G 1 20  LEU 20  20  20  LEU LEU B . 
G 1 21  CYS 21  21  21  CYS CYS B . 
G 1 22  ASP 22  22  22  ASP ASP B . 
G 1 23  ASP 23  23  23  ASP ASP B . 
G 1 24  GLY 24  24  24  GLY GLY B . 
G 1 25  LEU 25  25  25  LEU LEU B . 
G 1 26  LEU 26  26  26  LEU LEU B . 
G 1 27  GLY 27  27  27  GLY GLY B . 
G 1 28  ASN 28  28  28  ASN ASN B . 
G 1 29  GLU 29  29  29  GLU GLU B . 
G 1 30  ILE 30  30  30  ILE ILE B . 
G 1 31  ASP 31  31  31  ASP ASP B . 
G 1 32  VAL 32  32  32  VAL VAL B . 
G 1 33  VAL 33  33  33  VAL VAL B . 
G 1 34  ALA 34  34  34  ALA ALA B . 
G 1 35  VAL 35  35  35  VAL VAL B . 
G 1 36  VAL 36  36  36  VAL VAL B . 
G 1 37  ASP 37  37  37  ASP ASP B . 
G 1 38  MET 38  38  38  MET MET B . 
G 1 39  ASN 39  39  39  ASN ASN B . 
G 1 40  THR 40  40  40  THR THR B . 
G 1 41  ASP 41  41  41  ASP ASP B . 
G 1 42  ALA 42  42  42  ALA ALA B . 
G 1 43  ARG 43  43  43  ARG ARG B . 
G 1 44  TYR 44  44  44  TYR TYR B . 
G 1 45  PHE 45  45  45  PHE PHE B . 
G 1 46  ALA 46  46  46  ALA ALA B . 
G 1 47  TYR 47  47  47  TYR TYR B . 
G 1 48  GLN 48  48  48  GLN GLN B . 
G 1 49  MET 49  49  49  MET MET B . 
G 1 50  LYS 50  50  50  LYS LYS B . 
G 1 51  TYR 51  51  51  TYR TYR B . 
G 1 52  ASP 52  52  52  ASP ASP B . 
G 1 53  SER 53  53  53  SER SER B . 
G 1 54  VAL 54  54  54  VAL VAL B . 
G 1 55  HIS 55  55  55  HIS HIS B . 
G 1 56  GLY 56  56  56  GLY GLY B . 
G 1 57  LYS 57  57  57  LYS LYS B . 
G 1 58  PHE 58  58  58  PHE PHE B . 
G 1 59  LYS 59  59  59  LYS LYS B . 
G 1 60  HIS 60  60  60  HIS HIS B . 
G 1 61  SER 61  61  61  SER SER B . 
G 1 62  VAL 62  62  62  VAL VAL B . 
G 1 63  SER 63  63  63  SER SER B . 
G 1 64  THR 64  64  64  THR THR B . 
G 1 65  THR 65  65  65  THR THR B . 
G 1 66  LYS 66  66  66  LYS LYS B . 
G 1 67  SER 67  67  67  SER SER B . 
G 1 68  LYS 68  68  68  LYS LYS B . 
G 1 69  PRO 69  69  69  PRO PRO B . 
G 1 70  SER 70  70  70  SER SER B . 
G 1 71  VAL 71  71  71  VAL VAL B . 
G 1 72  ALA 72  72  72  ALA ALA B . 
G 1 73  LYS 73  73  73  LYS LYS B . 
G 1 74  ASP 74  74  74  ASP ASP B . 
G 1 75  ASP 75  75  75  ASP ASP B . 
G 1 76  THR 76  76  76  THR THR B . 
G 1 77  LEU 77  77  77  LEU LEU B . 
G 1 78  VAL 78  78  78  VAL VAL B . 
G 1 79  VAL 79  79  79  VAL VAL B . 
G 1 80  ASN 80  80  80  ASN ASN B . 
G 1 81  GLY 81  81  81  GLY GLY B . 
G 1 82  HIS 82  82  82  HIS HIS B . 
G 1 83  ARG 83  83  83  ARG ARG B . 
G 1 84  ILE 84  84  84  ILE ILE B . 
G 1 85  LEU 85  85  85  LEU LEU B . 
G 1 86  CYS 86  86  86  CYS CYS B . 
G 1 87  VAL 87  87  87  VAL VAL B . 
G 1 88  LYS 88  88  88  LYS LYS B . 
G 1 89  ALA 89  89  89  ALA ALA B . 
G 1 90  GLN 90  90  90  GLN GLN B . 
G 1 91  ARG 91  91  91  ARG ARG B . 
G 1 92  ASN 92  92  92  ASN ASN B . 
G 1 93  PRO 93  93  93  PRO PRO B . 
G 1 94  ALA 94  94  94  ALA ALA B . 
G 1 95  ASP 95  95  95  ASP ASP B . 
G 1 96  LEU 96  96  96  LEU LEU B . 
G 1 97  PRO 97  97  97  PRO PRO B . 
G 1 98  TRP 98  98  98  TRP TRP B . 
G 1 99  GLY 99  99  99  GLY GLY B . 
G 1 100 LYS 100 100 100 LYS LYS B . 
G 1 101 LEU 101 101 101 LEU LEU B . 
G 1 102 GLY 102 102 102 GLY GLY B . 
G 1 103 VAL 103 103 103 VAL VAL B . 
G 1 104 GLU 104 104 104 GLU GLU B . 
G 1 105 TYR 105 105 105 TYR TYR B . 
G 1 106 VAL 106 106 106 VAL VAL B . 
G 1 107 ILE 107 107 107 ILE ILE B . 
G 1 108 GLU 108 108 108 GLU GLU B . 
G 1 109 SER 109 109 109 SER SER B . 
G 1 110 THR 110 110 110 THR THR B . 
G 1 111 GLY 111 111 111 GLY GLY B . 
G 1 112 LEU 112 112 112 LEU LEU B . 
G 1 113 PHE 113 113 113 PHE PHE B . 
G 1 114 THR 114 114 114 THR THR B . 
G 1 115 VAL 115 115 115 VAL VAL B . 
G 1 116 LYS 116 116 116 LYS LYS B . 
G 1 117 SER 117 117 117 SER SER B . 
G 1 118 ALA 118 118 118 ALA ALA B . 
G 1 119 ALA 119 119 119 ALA ALA B . 
G 1 120 GLU 120 120 120 GLU GLU B . 
G 1 121 GLY 121 121 121 GLY GLY B . 
G 1 122 HIS 122 122 122 HIS HIS B . 
G 1 123 LEU 123 123 123 LEU LEU B . 
G 1 124 ARG 124 124 124 ARG ARG B . 
G 1 125 GLY 125 125 125 GLY GLY B . 
G 1 126 GLY 126 126 126 GLY GLY B . 
G 1 127 ALA 127 127 127 ALA ALA B . 
G 1 128 ARG 128 128 128 ARG ARG B . 
G 1 129 LYS 129 129 129 LYS LYS B . 
G 1 130 VAL 130 130 130 VAL VAL B . 
G 1 131 VAL 131 131 131 VAL VAL B . 
G 1 132 ILE 132 132 132 ILE ILE B . 
G 1 133 SER 133 133 133 SER SER B . 
G 1 134 ALA 134 134 134 ALA ALA B . 
G 1 135 PRO 135 135 135 PRO PRO B . 
G 1 136 ALA 136 136 136 ALA ALA B . 
G 1 137 SER 137 137 137 SER SER B . 
G 1 138 GLY 138 138 138 GLY GLY B . 
G 1 139 GLY 139 139 139 GLY GLY B . 
G 1 140 ALA 140 140 140 ALA ALA B . 
G 1 141 LYS 141 141 141 LYS LYS B . 
G 1 142 THR 142 142 142 THR THR B . 
G 1 143 PHE 143 143 143 PHE PHE B . 
G 1 144 VAL 144 144 144 VAL VAL B . 
G 1 145 MET 145 145 145 MET MET B . 
G 1 146 GLY 146 146 146 GLY GLY B . 
G 1 147 VAL 147 147 147 VAL VAL B . 
G 1 148 ASN 148 148 148 ASN ASN B . 
G 1 149 HIS 149 149 149 HIS HIS B . 
G 1 150 ASN 150 150 150 ASN ASN B . 
G 1 151 ASN 151 151 151 ASN ASN B . 
G 1 152 TYR 152 152 152 TYR TYR B . 
G 1 153 ASN 153 153 153 ASN ASN B . 
G 1 154 PRO 154 154 154 PRO PRO B . 
G 1 155 ARG 155 155 155 ARG ARG B . 
G 1 156 GLU 156 156 156 GLU GLU B . 
G 1 157 GLN 157 157 157 GLN GLN B . 
G 1 158 HIS 158 158 158 HIS HIS B . 
G 1 159 VAL 159 159 159 VAL VAL B . 
G 1 160 VAL 160 160 160 VAL VAL B . 
G 1 161 SER 161 161 161 SER SER B . 
G 1 162 ASN 162 162 162 ASN ASN B . 
G 1 163 ALA 163 163 163 ALA ALA B . 
G 1 164 SER 164 164 164 SER SER B . 
G 1 165 CYS 165 165 165 CYS CYS B . 
G 1 166 THR 166 166 166 THR THR B . 
G 1 167 THR 167 167 167 THR THR B . 
G 1 168 ASN 168 168 168 ASN ASN B . 
G 1 169 CYS 169 169 169 CYS CYS B . 
G 1 170 LEU 170 170 170 LEU LEU B . 
G 1 171 ALA 171 171 171 ALA ALA B . 
G 1 172 PRO 172 172 172 PRO PRO B . 
G 1 173 LEU 173 173 173 LEU LEU B . 
G 1 174 VAL 174 174 174 VAL VAL B . 
G 1 175 HIS 175 175 175 HIS HIS B . 
G 1 176 VAL 176 176 176 VAL VAL B . 
G 1 177 LEU 177 177 177 LEU LEU B . 
G 1 178 VAL 178 178 178 VAL VAL B . 
G 1 179 LYS 179 179 179 LYS LYS B . 
G 1 180 GLU 180 180 180 GLU GLU B . 
G 1 181 GLY 181 181 181 GLY GLY B . 
G 1 182 PHE 182 182 182 PHE PHE B . 
G 1 183 GLY 183 183 183 GLY GLY B . 
G 1 184 ILE 184 184 184 ILE ILE B . 
G 1 185 SER 185 185 185 SER SER B . 
G 1 186 THR 186 186 186 THR THR B . 
G 1 187 GLY 187 187 187 GLY GLY B . 
G 1 188 LEU 188 188 188 LEU LEU B . 
G 1 189 MET 189 189 189 MET MET B . 
G 1 190 THR 190 190 190 THR THR B . 
G 1 191 THR 191 191 191 THR THR B . 
G 1 192 VAL 192 192 192 VAL VAL B . 
G 1 193 HIS 193 193 193 HIS HIS B . 
G 1 194 SER 194 194 194 SER SER B . 
G 1 195 TYR 195 195 195 TYR TYR B . 
G 1 196 THR 196 196 196 THR THR B . 
G 1 197 ALA 197 197 197 ALA ALA B . 
G 1 198 THR 198 198 198 THR THR B . 
G 1 199 GLN 199 199 199 GLN GLN B . 
G 1 200 LYS 200 200 200 LYS LYS B . 
G 1 201 THR 201 201 201 THR THR B . 
G 1 202 VAL 202 202 202 VAL VAL B . 
G 1 203 ASP 203 203 203 ASP ASP B . 
G 1 204 GLY 204 204 204 GLY GLY B . 
G 1 205 VAL 205 205 205 VAL VAL B . 
G 1 206 SER 206 206 206 SER SER B . 
G 1 207 VAL 207 207 207 VAL VAL B . 
G 1 208 LYS 208 208 208 LYS LYS B . 
G 1 209 ASP 209 209 209 ASP ASP B . 
G 1 210 TRP 210 210 210 TRP TRP B . 
G 1 211 ARG 211 211 211 ARG ARG B . 
G 1 212 GLY 212 212 212 GLY GLY B . 
G 1 213 GLY 213 213 213 GLY GLY B . 
G 1 214 ARG 214 214 214 ARG ARG B . 
G 1 215 ALA 215 215 215 ALA ALA B . 
G 1 216 ALA 216 216 216 ALA ALA B . 
G 1 217 ALA 217 217 217 ALA ALA B . 
G 1 218 LEU 218 218 218 LEU LEU B . 
G 1 219 ASN 219 219 219 ASN ASN B . 
G 1 220 ILE 220 220 220 ILE ILE B . 
G 1 221 ILE 221 221 221 ILE ILE B . 
G 1 222 PRO 222 222 222 PRO PRO B . 
G 1 223 SER 223 223 223 SER SER B . 
G 1 224 THR 224 224 224 THR THR B . 
G 1 225 THR 225 225 225 THR THR B . 
G 1 226 GLY 226 226 226 GLY GLY B . 
G 1 227 ALA 227 227 227 ALA ALA B . 
G 1 228 ALA 228 228 228 ALA ALA B . 
G 1 229 LYS 229 229 229 LYS LYS B . 
G 1 230 ALA 230 230 230 ALA ALA B . 
G 1 231 VAL 231 231 231 VAL VAL B . 
G 1 232 GLY 232 232 232 GLY GLY B . 
G 1 233 MET 233 233 233 MET MET B . 
G 1 234 VAL 234 234 234 VAL VAL B . 
G 1 235 ILE 235 235 235 ILE ILE B . 
G 1 236 PRO 236 236 236 PRO PRO B . 
G 1 237 SER 237 237 237 SER SER B . 
G 1 238 THR 238 238 238 THR THR B . 
G 1 239 GLN 239 239 239 GLN GLN B . 
G 1 240 GLY 240 240 240 GLY GLY B . 
G 1 241 LYS 241 241 241 LYS LYS B . 
G 1 242 LEU 242 242 242 LEU LEU B . 
G 1 243 THR 243 243 243 THR THR B . 
G 1 244 GLY 244 244 244 GLY GLY B . 
G 1 245 MET 245 245 245 MET MET B . 
G 1 246 ALA 246 246 246 ALA ALA B . 
G 1 247 PHE 247 247 247 PHE PHE B . 
G 1 248 ARG 248 248 248 ARG ARG B . 
G 1 249 VAL 249 249 249 VAL VAL B . 
G 1 250 PRO 250 250 250 PRO PRO B . 
G 1 251 THR 251 251 251 THR THR B . 
G 1 252 ALA 252 252 252 ALA ALA B . 
G 1 253 ASP 253 253 253 ASP ASP B . 
G 1 254 VAL 254 254 254 VAL VAL B . 
G 1 255 SER 255 255 255 SER SER B . 
G 1 256 VAL 256 256 256 VAL VAL B . 
G 1 257 VAL 257 257 257 VAL VAL B . 
G 1 258 ASP 258 258 258 ASP ASP B . 
G 1 259 LEU 259 259 259 LEU LEU B . 
G 1 260 THR 260 260 260 THR THR B . 
G 1 261 PHE 261 261 261 PHE PHE B . 
G 1 262 ILE 262 262 262 ILE ILE B . 
G 1 263 ALA 263 263 263 ALA ALA B . 
G 1 264 THR 264 264 264 THR THR B . 
G 1 265 ARG 265 265 265 ARG ARG B . 
G 1 266 ASP 266 266 266 ASP ASP B . 
G 1 267 THR 267 267 267 THR THR B . 
G 1 268 SER 268 268 268 SER SER B . 
G 1 269 ILE 269 269 269 ILE ILE B . 
G 1 270 LYS 270 270 270 LYS LYS B . 
G 1 271 GLU 271 271 271 GLU GLU B . 
G 1 272 ILE 272 272 272 ILE ILE B . 
G 1 273 ASP 273 273 273 ASP ASP B . 
G 1 274 ALA 274 274 274 ALA ALA B . 
G 1 275 ALA 275 275 275 ALA ALA B . 
G 1 276 LEU 276 276 276 LEU LEU B . 
G 1 277 LYS 277 277 277 LYS LYS B . 
G 1 278 ARG 278 278 278 ARG ARG B . 
G 1 279 ALA 279 279 279 ALA ALA B . 
G 1 280 SER 280 280 280 SER SER B . 
G 1 281 LYS 281 281 281 LYS LYS B . 
G 1 282 THR 282 282 282 THR THR B . 
G 1 283 TYR 283 283 283 TYR TYR B . 
G 1 284 MET 284 284 284 MET MET B . 
G 1 285 LYS 285 285 285 LYS LYS B . 
G 1 286 ASN 286 286 286 ASN ASN B . 
G 1 287 ILE 287 287 287 ILE ILE B . 
G 1 288 LEU 288 288 288 LEU LEU B . 
G 1 289 GLY 289 289 289 GLY GLY B . 
G 1 290 TYR 290 290 290 TYR TYR B . 
G 1 291 THR 291 291 291 THR THR B . 
G 1 292 ASP 292 292 292 ASP ASP B . 
G 1 293 GLU 293 293 293 GLU GLU B . 
G 1 294 GLU 294 294 294 GLU GLU B . 
G 1 295 LEU 295 295 295 LEU LEU B . 
G 1 296 VAL 296 296 296 VAL VAL B . 
G 1 297 SER 297 297 297 SER SER B . 
G 1 298 ALA 298 298 298 ALA ALA B . 
G 1 299 ASP 299 299 299 ASP ASP B . 
G 1 300 PHE 300 300 300 PHE PHE B . 
G 1 301 ILE 301 301 301 ILE ILE B . 
G 1 302 SER 302 302 302 SER SER B . 
G 1 303 ASP 303 303 303 ASP ASP B . 
G 1 304 SER 304 304 304 SER SER B . 
G 1 305 ARG 305 305 305 ARG ARG B . 
G 1 306 SER 306 306 306 SER SER B . 
G 1 307 SER 307 307 307 SER SER B . 
G 1 308 ILE 308 308 308 ILE ILE B . 
G 1 309 TYR 309 309 309 TYR TYR B . 
G 1 310 ASP 310 310 310 ASP ASP B . 
G 1 311 SER 311 311 311 SER SER B . 
G 1 312 LYS 312 312 312 LYS LYS B . 
G 1 313 ALA 313 313 313 ALA ALA B . 
G 1 314 THR 314 314 314 THR THR B . 
G 1 315 LEU 315 315 315 LEU LEU B . 
G 1 316 GLN 316 316 316 GLN GLN B . 
G 1 317 ASN 317 317 317 ASN ASN B . 
G 1 318 ASN 318 318 318 ASN ASN B . 
G 1 319 LEU 319 319 319 LEU LEU B . 
G 1 320 PRO 320 320 320 PRO PRO B . 
G 1 321 ASN 321 321 321 ASN ASN B . 
G 1 322 GLU 322 322 322 GLU GLU B . 
G 1 323 ARG 323 323 323 ARG ARG B . 
G 1 324 ARG 324 324 324 ARG ARG B . 
G 1 325 PHE 325 325 325 PHE PHE B . 
G 1 326 PHE 326 326 326 PHE PHE B . 
G 1 327 LYS 327 327 327 LYS LYS B . 
G 1 328 ILE 328 328 328 ILE ILE B . 
G 1 329 VAL 329 329 329 VAL VAL B . 
G 1 330 SER 330 330 330 SER SER B . 
G 1 331 TRP 331 331 331 TRP TRP B . 
G 1 332 TYR 332 332 332 TYR TYR B . 
G 1 333 ASP 333 333 333 ASP ASP B . 
G 1 334 ASN 334 334 334 ASN ASN B . 
G 1 335 GLU 335 335 335 GLU GLU B . 
G 1 336 TRP 336 336 336 TRP TRP B . 
G 1 337 GLY 337 337 337 GLY GLY B . 
G 1 338 TYR 338 338 338 TYR TYR B . 
G 1 339 SER 339 339 339 SER SER B . 
G 1 340 HIS 340 340 340 HIS HIS B . 
G 1 341 ARG 341 341 341 ARG ARG B . 
G 1 342 VAL 342 342 342 VAL VAL B . 
G 1 343 VAL 343 343 343 VAL VAL B . 
G 1 344 ASP 344 344 344 ASP ASP B . 
G 1 345 LEU 345 345 345 LEU LEU B . 
G 1 346 VAL 346 346 346 VAL VAL B . 
G 1 347 ARG 347 347 347 ARG ARG B . 
G 1 348 HIS 348 348 348 HIS HIS B . 
G 1 349 MET 349 349 349 MET MET B . 
G 1 350 ALA 350 350 350 ALA ALA B . 
G 1 351 ALA 351 351 351 ALA ALA B . 
G 1 352 ARG 352 352 352 ARG ARG B . 
G 1 353 ASP 353 353 353 ASP ASP B . 
G 1 354 ARG 354 354 354 ARG ARG B . 
G 1 355 ALA 355 355 355 ALA ALA B . 
G 1 356 ALA 356 356 356 ALA ALA B . 
G 1 357 LYS 357 357 357 LYS LYS B . 
G 1 358 LEU 358 358 358 LEU LEU B . 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
I  2 SO4 1 359 359 SO4 SO4 O . 
J  2 SO4 1 360 360 SO4 SO4 O . 
K  2 SO4 1 359 359 SO4 SO4 P . 
L  2 SO4 1 360 360 SO4 SO4 P . 
M  2 SO4 1 359 359 SO4 SO4 Q . 
N  2 SO4 1 360 360 SO4 SO4 Q . 
O  2 SO4 1 359 359 SO4 SO4 R . 
P  2 SO4 1 360 360 SO4 SO4 R . 
Q  2 SO4 1 359 359 SO4 SO4 A . 
S  2 SO4 1 360 360 SO4 SO4 A . 
U  2 SO4 1 359 359 SO4 SO4 B . 
W  2 SO4 1 360 360 SO4 SO4 B . 
Y  3 NAD 1 361 361 NAD NAD O . 
Z  3 NAD 1 361 361 NAD NAD P . 
AA 3 NAD 1 361 361 NAD NAD Q . 
BA 3 NAD 1 361 361 NAD NAD R . 
CA 3 NAD 1 361 361 NAD NAD A . 
EA 3 NAD 1 361 361 NAD NAD B . 
# 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        16410 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         324 
_refine_hist.d_res_high                       3.2 
_refine_hist.d_res_low                        . 
# 
_struct.entry_id             1GGA 
_struct.title                
;STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM TRYPANOSOMA BRUCEI DETERMINED FROM LAUE DATA
;
_struct.pdbx_descriptor      
'D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (HOLO FORM) (E.C.1.2.1.12)' 
_struct.pdbx_model_details   ? 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A  N N 1 ? 
B  N N 1 ? 
C  N N 1 ? 
D  N N 1 ? 
E  N N 1 ? 
G  N N 1 ? 
I  N N 2 ? 
J  N N 2 ? 
K  N N 2 ? 
L  N N 2 ? 
M  N N 2 ? 
N  N N 2 ? 
O  N N 2 ? 
P  N N 2 ? 
Q  N N 2 ? 
S  N N 2 ? 
U  N N 2 ? 
W  N N 2 ? 
Y  N N 3 ? 
Z  N N 3 ? 
AA N N 3 ? 
BA N N 3 ? 
CA N N 3 ? 
EA N N 3 ? 
# 
loop_
_struct_biol_gen.biol_id 
_struct_biol_gen.asym_id 
_struct_biol_gen.symmetry 
_struct_biol_gen.details 
_struct_biol_gen.pdbx_full_symmetry_operation 
1 A  1_555 ? x,y,z    
1 B  1_555 ? x,y,z    
1 C  1_555 ? x,y,z    
1 D  1_555 ? x,y,z    
2 E  1_555 ? x,y,z    
2 E  2_655 ? 1-x,-y,z 
2 G  1_555 ? x,y,z    
2 G  2_655 ? 1-x,-y,z 
1 I  1_555 ? x,y,z    
1 J  1_555 ? x,y,z    
1 K  1_555 ? x,y,z    
1 L  1_555 ? x,y,z    
1 M  1_555 ? x,y,z    
1 N  1_555 ? x,y,z    
1 O  1_555 ? x,y,z    
1 P  1_555 ? x,y,z    
2 Q  1_555 ? x,y,z    
2 Q  2_655 ? 1-x,-y,z 
2 S  1_555 ? x,y,z    
2 S  2_655 ? 1-x,-y,z 
2 U  1_555 ? x,y,z    
2 U  2_655 ? 1-x,-y,z 
2 W  1_555 ? x,y,z    
2 W  2_655 ? 1-x,-y,z 
1 Y  1_555 ? x,y,z    
1 Z  1_555 ? x,y,z    
1 AA 1_555 ? x,y,z    
1 BA 1_555 ? x,y,z    
2 CA 1_555 ? x,y,z    
2 CA 2_655 ? 1-x,-y,z 
2 EA 1_555 ? x,y,z    
2 EA 2_655 ? 1-x,-y,z 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  1  ILE A 12  ? ASP A 22  ? ILE O 12  ASP O 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P2  2  ALA A 42  ? LYS A 50  ? ALA O 42  LYS O 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P3  3  PRO A 93  ? ASP A 95  ? PRO O 93  ASP O 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P4  4  TRP A 98  ? LEU A 101 ? TRP O 98  LEU O 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P5  5  THR A 110 ? ARG A 124 ? THR O 110 ARG O 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P6  6  CYS A 165 ? LYS A 179 ? CYS O 165 LYS O 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P7  7  TRP A 210 ? GLY A 213 ? TRP O 210 GLY O 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P8  8  ALA A 216 ? LEU A 218 ? ALA O 216 LEU O 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P9  9  GLY A 226 ? VAL A 234 ? GLY O 226 VAL O 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P10 10 PRO A 236 ? THR A 238 ? PRO O 236 THR O 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P11 11 ILE A 269 ? LYS A 281 ? ILE O 269 LYS O 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P12 12 SER A 311 ? GLN A 316 ? SER O 311 GLN O 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P13 13 GLU A 335 ? ARG A 352 ? GLU O 335 ARG O 352 1 
'HELIX ALPHA 3'  18 
HELX_P HELX_P14 14 ILE B 12  ? ASP B 22  ? ILE P 12  ASP P 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P15 15 ALA B 42  ? LYS B 50  ? ALA P 42  LYS P 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P16 16 PRO B 93  ? ASP B 95  ? PRO P 93  ASP P 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P17 17 TRP B 98  ? LEU B 101 ? TRP P 98  LEU P 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P18 18 THR B 110 ? ARG B 124 ? THR P 110 ARG P 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P19 19 CYS B 165 ? LYS B 179 ? CYS P 165 LYS P 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P20 20 TRP B 210 ? GLY B 213 ? TRP P 210 GLY P 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P21 21 ALA B 216 ? LEU B 218 ? ALA P 216 LEU P 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P22 22 GLY B 226 ? VAL B 234 ? GLY P 226 VAL P 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P23 23 PRO B 236 ? THR B 238 ? PRO P 236 THR P 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P24 24 ILE B 269 ? LYS B 281 ? ILE P 269 LYS P 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P25 25 SER B 311 ? GLN B 316 ? SER P 311 GLN P 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P26 26 GLU B 335 ? ARG B 352 ? GLU P 335 ARG P 352 1 
'HELIX ALPHA 3'  18 
HELX_P HELX_P27 27 ILE C 12  ? ASP C 22  ? ILE Q 12  ASP Q 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P28 28 ALA C 42  ? LYS C 50  ? ALA Q 42  LYS Q 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P29 29 PRO C 93  ? ASP C 95  ? PRO Q 93  ASP Q 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P30 30 TRP C 98  ? LEU C 101 ? TRP Q 98  LEU Q 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P31 31 THR C 110 ? ARG C 124 ? THR Q 110 ARG Q 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P32 32 CYS C 165 ? LYS C 179 ? CYS Q 165 LYS Q 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P33 33 TRP C 210 ? GLY C 213 ? TRP Q 210 GLY Q 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P34 34 ALA C 216 ? LEU C 218 ? ALA Q 216 LEU Q 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P35 35 GLY C 226 ? VAL C 234 ? GLY Q 226 VAL Q 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P36 36 PRO C 236 ? THR C 238 ? PRO Q 236 THR Q 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P37 37 ILE C 269 ? LYS C 281 ? ILE Q 269 LYS Q 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P38 38 SER C 311 ? GLN C 316 ? SER Q 311 GLN Q 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P39 39 GLU C 335 ? ARG C 352 ? GLU Q 335 ARG Q 352 1 
'HELIX ALPHA 3'  18 
HELX_P HELX_P40 40 ILE D 12  ? ASP D 22  ? ILE R 12  ASP R 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P41 41 ALA D 42  ? LYS D 50  ? ALA R 42  LYS R 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P42 42 PRO D 93  ? ASP D 95  ? PRO R 93  ASP R 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P43 43 TRP D 98  ? LEU D 101 ? TRP R 98  LEU R 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P44 44 THR D 110 ? ARG D 124 ? THR R 110 ARG R 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P45 45 CYS D 165 ? LYS D 179 ? CYS R 165 LYS R 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P46 46 TRP D 210 ? GLY D 213 ? TRP R 210 GLY R 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P47 47 ALA D 216 ? LEU D 218 ? ALA R 216 LEU R 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P48 48 GLY D 226 ? VAL D 234 ? GLY R 226 VAL R 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P49 49 PRO D 236 ? THR D 238 ? PRO R 236 THR R 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P50 50 ILE D 269 ? LYS D 281 ? ILE R 269 LYS R 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P51 51 SER D 311 ? GLN D 316 ? SER R 311 GLN R 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P52 52 GLU D 335 ? ARG D 352 ? GLU R 335 ARG R 352 1 
'HELIX ALPHA 3'  18 
HELX_P HELX_P53 53 ILE E 12  ? ASP E 22  ? ILE A 12  ASP A 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P54 54 ALA E 42  ? LYS E 50  ? ALA A 42  LYS A 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P55 55 PRO E 93  ? ASP E 95  ? PRO A 93  ASP A 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P56 56 TRP E 98  ? LEU E 101 ? TRP A 98  LEU A 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P57 57 THR E 110 ? ARG E 124 ? THR A 110 ARG A 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P58 58 CYS E 165 ? LYS E 179 ? CYS A 165 LYS A 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P59 59 TRP E 210 ? GLY E 213 ? TRP A 210 GLY A 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P60 60 ALA E 216 ? LEU E 218 ? ALA A 216 LEU A 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P61 61 GLY E 226 ? VAL E 234 ? GLY A 226 VAL A 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P62 62 PRO E 236 ? THR E 238 ? PRO A 236 THR A 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P63 63 ILE E 269 ? LYS E 281 ? ILE A 269 LYS A 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P64 64 SER E 311 ? GLN E 316 ? SER A 311 GLN A 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P65 65 GLU E 335 ? ARG E 352 ? GLU A 335 ARG A 352 1 
'HELIX ALPHA 3'  18 
HELX_P HELX_P66 66 ILE G 12  ? ASP G 22  ? ILE B 12  ASP B 22  1 
'HELIX ALPHA B'  11 
HELX_P HELX_P67 67 ALA G 42  ? LYS G 50  ? ALA B 42  LYS B 50  1 
'HELIX ALPHA C'  9  
HELX_P HELX_P68 68 PRO G 93  ? ASP G 95  ? PRO B 93  ASP B 95  5 '3/10 HELIX' 
3  
HELX_P HELX_P69 69 TRP G 98  ? LEU G 101 ? TRP B 98  LEU B 101 1 
'HELIX ALPHA D'  4  
HELX_P HELX_P70 70 THR G 110 ? ARG G 124 ? THR B 110 ARG B 124 1 
'HELIX ALPHA E'  15 
HELX_P HELX_P71 71 CYS G 165 ? LYS G 179 ? CYS B 165 LYS B 179 1 
'HELIX ALPHA 1'  15 
HELX_P HELX_P72 72 TRP G 210 ? GLY G 213 ? TRP B 210 GLY B 213 5 '3/10 HELIX' 
4  
HELX_P HELX_P73 73 ALA G 216 ? LEU G 218 ? ALA B 216 LEU B 218 5 '3/10 HELIX' 
3  
HELX_P HELX_P74 74 GLY G 226 ? VAL G 234 ? GLY B 226 VAL B 234 1 
;HELIX ALPHA 2'
;
9  
HELX_P HELX_P75 75 PRO G 236 ? THR G 238 ? PRO B 236 THR B 238 5 '3/10 HELIX' 
3  
HELX_P HELX_P76 76 ILE G 269 ? LYS G 281 ? ILE B 269 LYS B 281 1 
'HELIX ALPHA 2'  13 
HELX_P HELX_P77 77 SER G 311 ? GLN G 316 ? SER B 311 GLN B 316 1 
'HELIX ALPHA 7'  6  
HELX_P HELX_P78 78 GLU G 335 ? ARG G 352 ? GLU B 335 ARG B 352 1 
'HELIX ALPHA 3'  18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_ncs_oper.id 
_struct_ncs_oper.code 
_struct_ncs_oper.details 
_struct_ncs_oper.matrix[1][1] 
_struct_ncs_oper.matrix[1][2] 
_struct_ncs_oper.matrix[1][3] 
_struct_ncs_oper.matrix[2][1] 
_struct_ncs_oper.matrix[2][2] 
_struct_ncs_oper.matrix[2][3] 
_struct_ncs_oper.matrix[3][1] 
_struct_ncs_oper.matrix[3][2] 
_struct_ncs_oper.matrix[3][3] 
_struct_ncs_oper.vector[1] 
_struct_ncs_oper.vector[2] 
_struct_ncs_oper.vector[3] 
1 given ? -0.302545 0.952935  0.019533  0.952976  0.302057  0.024466  0.017414 
0.026016  -0.999510 -33.82500 24.20300  36.91800 
2 given ? -0.999943 0.001515  -0.010619 -0.001211 -0.999591 -0.028579 
-0.010658 -0.028564 0.999535  41.80700  127.79200 2.10300  
3 given ? 0.303086  -0.952922 -0.008913 -0.952887 -0.303166 0.009782  
-0.012023 0.005528  -0.999912 75.32600  102.54600 38.86700 
4 given ? 0.292070  0.956341  0.010322  0.956397  -0.292058 -0.002662 0.000469 
0.010650  -0.999943 0.66000   -1.22900  75.11200 
5 given ? -0.819285 -0.573333 -0.007803 0.573386  -0.819188 -0.012666 0.000870 
-0.014852 0.999889  121.43200 40.44000  37.72700 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
S1  ? 9 ? 
S2  ? 7 ? 
S3  ? 9 ? 
S4  ? 7 ? 
S5  ? 9 ? 
S6  ? 7 ? 
S7  ? 9 ? 
S8  ? 7 ? 
S9  ? 9 ? 
S10 ? 7 ? 
S11 ? 9 ? 
S12 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
S1  1 2 ? anti-parallel 
S1  2 3 ? anti-parallel 
S1  3 4 ? parallel      
S1  4 5 ? parallel      
S1  5 6 ? parallel      
S1  6 7 ? parallel      
S1  7 8 ? parallel      
S1  8 9 ? parallel      
S2  1 2 ? parallel      
S2  2 3 ? anti-parallel 
S2  3 4 ? anti-parallel 
S2  4 5 ? anti-parallel 
S2  5 6 ? parallel      
S2  6 7 ? anti-parallel 
S3  1 2 ? anti-parallel 
S3  2 3 ? anti-parallel 
S3  3 4 ? parallel      
S3  4 5 ? parallel      
S3  5 6 ? parallel      
S3  6 7 ? parallel      
S3  7 8 ? parallel      
S3  8 9 ? parallel      
S4  1 2 ? parallel      
S4  2 3 ? anti-parallel 
S4  3 4 ? anti-parallel 
S4  4 5 ? anti-parallel 
S4  5 6 ? parallel      
S4  6 7 ? anti-parallel 
S5  1 2 ? anti-parallel 
S5  2 3 ? anti-parallel 
S5  3 4 ? parallel      
S5  4 5 ? parallel      
S5  5 6 ? parallel      
S5  6 7 ? parallel      
S5  7 8 ? parallel      
S5  8 9 ? parallel      
S6  1 2 ? parallel      
S6  2 3 ? anti-parallel 
S6  3 4 ? anti-parallel 
S6  4 5 ? anti-parallel 
S6  5 6 ? parallel      
S6  6 7 ? anti-parallel 
S7  1 2 ? anti-parallel 
S7  2 3 ? anti-parallel 
S7  3 4 ? parallel      
S7  4 5 ? parallel      
S7  5 6 ? parallel      
S7  6 7 ? parallel      
S7  7 8 ? parallel      
S7  8 9 ? parallel      
S8  1 2 ? parallel      
S8  2 3 ? anti-parallel 
S8  3 4 ? anti-parallel 
S8  4 5 ? anti-parallel 
S8  5 6 ? parallel      
S8  6 7 ? anti-parallel 
S9  1 2 ? anti-parallel 
S9  2 3 ? anti-parallel 
S9  3 4 ? parallel      
S9  4 5 ? parallel      
S9  5 6 ? parallel      
S9  6 7 ? parallel      
S9  7 8 ? parallel      
S9  8 9 ? parallel      
S10 1 2 ? parallel      
S10 2 3 ? anti-parallel 
S10 3 4 ? anti-parallel 
S10 4 5 ? anti-parallel 
S10 5 6 ? parallel      
S10 6 7 ? anti-parallel 
S11 1 2 ? anti-parallel 
S11 2 3 ? anti-parallel 
S11 3 4 ? parallel      
S11 4 5 ? parallel      
S11 5 6 ? parallel      
S11 6 7 ? parallel      
S11 7 8 ? parallel      
S11 8 9 ? parallel      
S12 1 2 ? parallel      
S12 2 3 ? anti-parallel 
S12 3 4 ? anti-parallel 
S12 4 5 ? anti-parallel 
S12 5 6 ? parallel      
S12 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.symmetry 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
S1  1 VAL A 62  ? THR A 65  ? ? VAL O 62  THR O 65  
S1  2 THR A 76  ? VAL A 79  ? ? THR O 76  VAL O 79  
S1  3 HIS A 82  ? LYS A 88  ? ? HIS O 82  LYS O 88  
S1  4 ILE A 30  ? ASP A 37  ? ? ILE O 30  ASP O 37  
S1  5 ILE A 2   ? ASN A 7   ? ? ILE O 2   ASN O 7   
S1  6 TYR A 105 ? GLU A 108 ? ? TYR O 105 GLU O 108 
S1  7 LYS A 129 ? ILE A 132 ? ? LYS O 129 ILE O 132 
S1  8 VAL A 159 ? SER A 161 ? ? VAL O 159 SER O 161 
S1  9 ALA A 140 ? VAL A 144 ? ? ALA O 140 VAL O 144 
S2  1 LEU A 288 ? THR A 291 ? ? LEU O 288 THR O 291 
S2  2 SER A 307 ? ASP A 310 ? ? SER O 307 ASP O 310 
S2  3 PHE A 325 ? ASP A 333 ? ? PHE O 325 ASP O 333 
S2  4 SER A 255 ? ILE A 262 ? ? SER O 255 ILE O 262 
S2  5 THR A 186 ? SER A 194 ? ? THR O 186 SER O 194 
S2  6 LEU A 242 ? VAL A 249 ? ? LEU O 242 VAL O 249 
S2  7 ASN A 219 ? THR A 225 ? ? ASN O 219 THR O 225 
S3  1 VAL B 62  ? THR B 65  ? ? VAL P 62  THR P 65  
S3  2 THR B 76  ? VAL B 79  ? ? THR P 76  VAL P 79  
S3  3 HIS B 82  ? LYS B 88  ? ? HIS P 82  LYS P 88  
S3  4 ILE B 30  ? ASP B 37  ? ? ILE P 30  ASP P 37  
S3  5 ILE B 2   ? ASN B 7   ? ? ILE P 2   ASN P 7   
S3  6 TYR B 105 ? GLU B 108 ? ? TYR P 105 GLU P 108 
S3  7 LYS B 129 ? ILE B 132 ? ? LYS P 129 ILE P 132 
S3  8 VAL B 159 ? SER B 161 ? ? VAL P 159 SER P 161 
S3  9 ALA B 140 ? VAL B 144 ? ? ALA P 140 VAL P 144 
S4  1 LEU B 288 ? THR B 291 ? ? LEU P 288 THR P 291 
S4  2 SER B 307 ? ASP B 310 ? ? SER P 307 ASP P 310 
S4  3 PHE B 325 ? ASP B 333 ? ? PHE P 325 ASP P 333 
S4  4 SER B 255 ? ILE B 262 ? ? SER P 255 ILE P 262 
S4  5 THR B 186 ? SER B 194 ? ? THR P 186 SER P 194 
S4  6 LEU B 242 ? VAL B 249 ? ? LEU P 242 VAL P 249 
S4  7 ASN B 219 ? THR B 225 ? ? ASN P 219 THR P 225 
S5  1 VAL C 62  ? THR C 65  ? ? VAL Q 62  THR Q 65  
S5  2 THR C 76  ? VAL C 79  ? ? THR Q 76  VAL Q 79  
S5  3 HIS C 82  ? LYS C 88  ? ? HIS Q 82  LYS Q 88  
S5  4 ILE C 30  ? ASP C 37  ? ? ILE Q 30  ASP Q 37  
S5  5 ILE C 2   ? ASN C 7   ? ? ILE Q 2   ASN Q 7   
S5  6 TYR C 105 ? GLU C 108 ? ? TYR Q 105 GLU Q 108 
S5  7 LYS C 129 ? ILE C 132 ? ? LYS Q 129 ILE Q 132 
S5  8 VAL C 159 ? SER C 161 ? ? VAL Q 159 SER Q 161 
S5  9 ALA C 140 ? VAL C 144 ? ? ALA Q 140 VAL Q 144 
S6  1 LEU C 288 ? THR C 291 ? ? LEU Q 288 THR Q 291 
S6  2 SER C 307 ? ASP C 310 ? ? SER Q 307 ASP Q 310 
S6  3 PHE C 325 ? ASP C 333 ? ? PHE Q 325 ASP Q 333 
S6  4 SER C 255 ? ILE C 262 ? ? SER Q 255 ILE Q 262 
S6  5 THR C 186 ? SER C 194 ? ? THR Q 186 SER Q 194 
S6  6 LEU C 242 ? VAL C 249 ? ? LEU Q 242 VAL Q 249 
S6  7 ASN C 219 ? THR C 225 ? ? ASN Q 219 THR Q 225 
S7  1 VAL D 62  ? THR D 65  ? ? VAL R 62  THR R 65  
S7  2 THR D 76  ? VAL D 79  ? ? THR R 76  VAL R 79  
S7  3 HIS D 82  ? LYS D 88  ? ? HIS R 82  LYS R 88  
S7  4 ILE D 30  ? ASP D 37  ? ? ILE R 30  ASP R 37  
S7  5 ILE D 2   ? ASN D 7   ? ? ILE R 2   ASN R 7   
S7  6 TYR D 105 ? GLU D 108 ? ? TYR R 105 GLU R 108 
S7  7 LYS D 129 ? ILE D 132 ? ? LYS R 129 ILE R 132 
S7  8 VAL D 159 ? SER D 161 ? ? VAL R 159 SER R 161 
S7  9 ALA D 140 ? VAL D 144 ? ? ALA R 140 VAL R 144 
S8  1 LEU D 288 ? THR D 291 ? ? LEU R 288 THR R 291 
S8  2 SER D 307 ? ASP D 310 ? ? SER R 307 ASP R 310 
S8  3 PHE D 325 ? ASP D 333 ? ? PHE R 325 ASP R 333 
S8  4 SER D 255 ? ILE D 262 ? ? SER R 255 ILE R 262 
S8  5 THR D 186 ? SER D 194 ? ? THR R 186 SER R 194 
S8  6 LEU D 242 ? VAL D 249 ? ? LEU R 242 VAL R 249 
S8  7 ASN D 219 ? THR D 225 ? ? ASN R 219 THR R 225 
S9  1 VAL E 62  ? THR E 65  ? ? VAL A 62  THR A 65  
S9  2 THR E 76  ? VAL E 79  ? ? THR A 76  VAL A 79  
S9  3 HIS E 82  ? LYS E 88  ? ? HIS A 82  LYS A 88  
S9  4 ILE E 30  ? ASP E 37  ? ? ILE A 30  ASP A 37  
S9  5 ILE E 2   ? ASN E 7   ? ? ILE A 2   ASN A 7   
S9  6 TYR E 105 ? GLU E 108 ? ? TYR A 105 GLU A 108 
S9  7 LYS E 129 ? ILE E 132 ? ? LYS A 129 ILE A 132 
S9  8 VAL E 159 ? SER E 161 ? ? VAL A 159 SER A 161 
S9  9 ALA E 140 ? VAL E 144 ? ? ALA A 140 VAL A 144 
S10 1 LEU E 288 ? THR E 291 ? ? LEU A 288 THR A 291 
S10 2 SER E 307 ? ASP E 310 ? ? SER A 307 ASP A 310 
S10 3 PHE E 325 ? ASP E 333 ? ? PHE A 325 ASP A 333 
S10 4 SER E 255 ? ILE E 262 ? ? SER A 255 ILE A 262 
S10 5 THR E 186 ? SER E 194 ? ? THR A 186 SER A 194 
S10 6 LEU E 242 ? VAL E 249 ? ? LEU A 242 VAL A 249 
S10 7 ASN E 219 ? THR E 225 ? ? ASN A 219 THR A 225 
S11 1 VAL G 62  ? THR G 65  ? ? VAL B 62  THR B 65  
S11 2 THR G 76  ? VAL G 79  ? ? THR B 76  VAL B 79  
S11 3 HIS G 82  ? LYS G 88  ? ? HIS B 82  LYS B 88  
S11 4 ILE G 30  ? ASP G 37  ? ? ILE B 30  ASP B 37  
S11 5 ILE G 2   ? ASN G 7   ? ? ILE B 2   ASN B 7   
S11 6 TYR G 105 ? GLU G 108 ? ? TYR B 105 GLU B 108 
S11 7 LYS G 129 ? ILE G 132 ? ? LYS B 129 ILE B 132 
S11 8 VAL G 159 ? SER G 161 ? ? VAL B 159 SER B 161 
S11 9 ALA G 140 ? VAL G 144 ? ? ALA B 140 VAL B 144 
S12 1 LEU G 288 ? THR G 291 ? ? LEU B 288 THR B 291 
S12 2 SER G 307 ? ASP G 310 ? ? SER B 307 ASP B 310 
S12 3 PHE G 325 ? ASP G 333 ? ? PHE B 325 ASP B 333 
S12 4 SER G 255 ? ILE G 262 ? ? SER B 255 ILE B 262 
S12 5 THR G 186 ? SER G 194 ? ? THR B 186 SER B 194 
S12 6 LEU G 242 ? VAL G 249 ? ? LEU B 242 VAL B 249 
S12 7 ASN G 219 ? THR G 225 ? ? ASN B 219 THR B 225 
# 
loop_
_software.name 
_software.classification 
_software.version 
_software.citation_id 
X-PLOR 'model building' . . 
X-PLOR refinement       . . 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   . 
_diffrn_radiation_wavelength.wt           1.0 
# 
loop_
_atom_type.symbol 
N 
C 
O 
S 
P 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
THR 'L-peptide linking' y THREONINE                         ? 'C4 H9 N1 O3' 
119.120 
ILE 'L-peptide linking' y ISOLEUCINE                        ? 'C6 H13 N1 O2' 
131.174 
LYS 'L-peptide linking' y LYSINE                            ? 
'C6 H15 N2 O2 1+'   147.197 
VAL 'L-peptide linking' y VALINE                            ? 'C5 H11 N1 O2' 
117.147 
GLY 'L-peptide linking' y GLYCINE                           ? 'C2 H5 N1 O2' 
75.067  
ASN 'L-peptide linking' y ASPARAGINE                        ? 'C4 H8 N2 O3' 
132.119 
PHE 'L-peptide linking' y PHENYLALANINE                     ? 'C9 H11 N1 O2' 
165.191 
ARG 'L-peptide linking' y ARGININE                          ? 
'C6 H15 N4 O2 1+'   175.210 
MET 'L-peptide linking' y METHIONINE                        ? 
'C5 H11 N1 O2 S1'   149.207 
GLN 'L-peptide linking' y GLUTAMINE                         ? 'C5 H10 N2 O3' 
146.146 
ALA 'L-peptide linking' y ALANINE                           ? 'C3 H7 N1 O2' 
89.094  
LEU 'L-peptide linking' y LEUCINE                           ? 'C6 H13 N1 O2' 
131.174 
CYS 'L-peptide linking' y CYSTEINE                          ? 'C3 H7 N1 O2 S1' 
121.154 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                   ? 'C4 H7 N1 O4' 
133.104 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                   ? 'C5 H9 N1 O4' 
147.130 
TYR 'L-peptide linking' y TYROSINE                          ? 'C9 H11 N1 O3' 
181.191 
SER 'L-peptide linking' y SERINE                            ? 'C3 H7 N1 O3' 
105.093 
HIS 'L-peptide linking' y HISTIDINE                         ? 
'C6 H10 N3 O2 1+'   156.164 
PRO 'L-peptide linking' y PROLINE                           ? 'C5 H10 N1 O2' 
116.140 
TRP 'L-peptide linking' y TRYPTOPHAN                        ? 'C11 H12 N2 O2' 
204.228 
SO4 non-polymer         . 'SULFATE ION'                     ? 'O4 S1 2-' 
96.058  
NAD non-polymer         . NICOTINAMIDE-ADENINE-DINUCLEOTIDE ? 
'C21 H27 N7 O14 P2' 663.430 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
primary 'Vellieux, F.M.'    1  
primary 'Hajdu, J.'         2  
primary 'Verlinde, C.L.'    3  
primary 'Groendijk, H.'     4  
primary 'Read, R.J.'        5  
primary 'Greenhough, T.J.'  6  
primary 'Campbell, J.W.'    7  
primary 'Kalk, K.H.'        8  
primary 'Littlechild, J.A.' 9  
primary 'Watson, H.C.'      10 
primary 'al., et'           11 
1       'Read, R.J.'        12 
1       'Wierenga, R.K.'    13 
1       'Groendijk, H.'     14 
1       'Lambeir, A.'       15 
1       'Opperdoes, F.R.'   16 
1       'Hol, W.G.J.'       17 
2       'Michels, P.A.M.'   18 
2       'Poliszczak, A.'    19 
2       'Osinga, K.A.'      20 
2       'Misset, O.'        21 
2       'Van Beeumen, J.'   22 
2       'Wierenga, R.K.'    23 
2       'Borst, P.'         24 
2       'Opperdoes, F.R.'   25 
# 
_pdbx_database_status.status_code                        REL 
_pdbx_database_status.entry_id                           1GGA 
_pdbx_database_status.recvd_deposit_form                 ? 
_pdbx_database_status.date_deposition_form               ? 
_pdbx_database_status.recvd_coordinates                  ? 
_pdbx_database_status.date_coordinates                   ? 
_pdbx_database_status.recvd_struct_fact                  ? 
_pdbx_database_status.date_struct_fact                   ? 
_pdbx_database_status.recvd_internal_approval            ? 
_pdbx_database_status.recvd_nmr_constraints              ? 
_pdbx_database_status.date_nmr_constraints               ? 
_pdbx_database_status.recvd_manuscript                   ? 
_pdbx_database_status.date_manuscript                    ? 
_pdbx_database_status.name_depositor                     ? 
_pdbx_database_status.rcsb_annotator                     ? 
_pdbx_database_status.recvd_author_approval              ? 
_pdbx_database_status.date_author_approval               ? 
_pdbx_database_status.recvd_initial_deposition_date      ? 
_pdbx_database_status.date_submitted                     ? 
_pdbx_database_status.author_approval_type               ? 
_pdbx_database_status.author_release_status_code         ? 
_pdbx_database_status.date_of_PDB_release                ? 
_pdbx_database_status.date_hold_coordinates              ? 
_pdbx_database_status.date_hold_struct_fact              ? 
_pdbx_database_status.hold_for_publication               ? 
_pdbx_database_status.date_hold_nmr_constraints          ? 
_pdbx_database_status.dep_release_code_coordinates       . 
_pdbx_database_status.dep_release_code_struct_fact       . 
_pdbx_database_status.dep_release_code_nmr_constraints   . 
_pdbx_database_status.pdb_date_of_author_approval        ? 
_pdbx_database_status.deposit_site                       ? 
_pdbx_database_status.process_site                       ? 
_pdbx_database_status.dep_release_code_sequence          . 
# 
loop_
_audit_conform.dict_name 
_audit_conform.dict_version 
_audit_conform.dict_location 
cif_mm.dic   2.0.03 http://pdb.rutgers.edu/mmcif/dictionaries/ascii/cif_mm.dic 
cif_pdbx.dic 0.8.07 
http://pdb.rutgers.edu/mmcif/dictionaries/ascii/pdbx_exchange.dic 
# 
loop_
_audit.revision_id 
_audit.creation_date 
_audit.update_record 
1 1994-01-31 'initial release'                   
2 2003-04-01 'adjusted to citation information.' 
# 
_pdbx_audit.entry_id          1GGA 
_pdbx_audit.current_version   2 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'SULFATE ION'                     SO4 
3 NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.Cartn_x_esd 
_atom_site.Cartn_y_esd 
_atom_site.Cartn_z_esd 
_atom_site.occupancy_esd 
_atom_site.B_iso_or_equiv_esd 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
HETATM 16411 S S     . SO4 I  2 .   ? 21.165  82.692  14.720  1.00 96.41  ? ? 
? ? ? 359 SO4 O S    1 
HETATM 16412 O O1    . SO4 I  2 .   ? 22.439  82.098  14.391  1.00 95.40  ? ? 
? ? ? 359 SO4 O O1   1 
HETATM 16413 O O2    . SO4 I  2 .   ? 20.882  82.391  16.094  1.00 95.60  ? ? 
? ? ? 359 SO4 O O2   1 
HETATM 16414 O O3    . SO4 I  2 .   ? 21.222  84.110  14.524  1.00 94.12  ? ? 
? ? ? 359 SO4 O O3   1 
HETATM 16415 O O4    . SO4 I  2 .   ? 20.123  82.150  13.876  1.00 96.17  ? ? 
? ? ? 359 SO4 O O4   1 
HETATM 16416 S S     . SO4 J  2 .   ? 14.073  86.606  14.199  1.00 91.04  ? ? 
? ? ? 360 SO4 O S    1 
HETATM 16417 O O1    . SO4 J  2 .   ? 14.402  86.728  15.575  1.00 88.93  ? ? 
? ? ? 360 SO4 O O1   1 
HETATM 16418 O O2    . SO4 J  2 .   ? 13.995  87.900  13.585  1.00 90.55  ? ? 
? ? ? 360 SO4 O O2   1 
HETATM 16419 O O3    . SO4 J  2 .   ? 14.976  85.735  13.533  1.00 90.22  ? ? 
? ? ? 360 SO4 O O3   1 
HETATM 16420 O O4    . SO4 J  2 .   ? 12.781  86.044  13.976  1.00 92.82  ? ? 
? ? ? 360 SO4 O O4   1 
HETATM 16421 S S     . SO4 K  2 .   ? 2.908   57.588  24.391  1.00 93.23  ? ? 
? ? ? 359 SO4 P S    1 
HETATM 16422 O O1    . SO4 K  2 .   ? 3.866   56.560  24.717  1.00 93.65  ? ? 
? ? ? 359 SO4 P O1   1 
HETATM 16423 O O2    . SO4 K  2 .   ? 3.098   57.946  23.018  1.00 93.15  ? ? 
? ? ? 359 SO4 P O2   1 
HETATM 16424 O O3    . SO4 K  2 .   ? 1.589   57.110  24.594  1.00 93.00  ? ? 
? ? ? 359 SO4 P O3   1 
HETATM 16425 O O4    . SO4 K  2 .   ? 3.115   58.725  25.228  1.00 93.19  ? ? 
? ? ? 359 SO4 P O4   1 
HETATM 16426 S S     . SO4 L  2 .   ? -2.945  63.184  24.983  1.00 94.26  ? ? 
? ? ? 360 SO4 P S    1 
HETATM 16427 O O1    . SO4 L  2 .   ? -2.978  62.814  23.597  1.00 92.13  ? ? 
? ? ? 360 SO4 P O1   1 
HETATM 16428 O O2    . SO4 L  2 .   ? -4.204  62.847  25.589  1.00 93.99  ? ? 
? ? ? 360 SO4 P O2   1 
HETATM 16429 O O3    . SO4 L  2 .   ? -1.838  62.560  25.631  1.00 92.56  ? ? 
? ? ? 360 SO4 P O3   1 
HETATM 16430 O O4    . SO4 L  2 .   ? -2.797  64.577  25.204  1.00 92.97  ? ? 
? ? ? 360 SO4 P O4   1 
HETATM 16431 S S     . SO4 M  2 .   ? 20.603  44.832  14.097  1.00 97.53  ? ? 
? ? ? 359 SO4 Q S    1 
HETATM 16432 O O1    . SO4 M  2 .   ? 19.339  45.433  13.769  1.00 96.05  ? ? 
? ? ? 359 SO4 Q O1   1 
HETATM 16433 O O2    . SO4 M  2 .   ? 20.884  45.076  15.479  1.00 95.82  ? ? 
? ? ? 359 SO4 Q O2   1 
HETATM 16434 O O3    . SO4 M  2 .   ? 20.552  43.413  13.853  1.00 95.55  ? ? 
? ? ? 359 SO4 Q O3   1 
HETATM 16435 O O4    . SO4 M  2 .   ? 21.660  45.399  13.289  1.00 96.26  ? ? 
? ? ? 359 SO4 Q O4   1 
HETATM 16436 S S     . SO4 N  2 .   ? 27.733  40.935  13.494  1.00 89.36  ? ? 
? ? ? 360 SO4 Q S    1 
HETATM 16437 O O1    . SO4 N  2 .   ? 27.381  40.751  14.865  1.00 89.53  ? ? 
? ? ? 360 SO4 Q O1   1 
HETATM 16438 O O2    . SO4 N  2 .   ? 27.802  39.663  12.852  1.00 89.30  ? ? 
? ? ? 360 SO4 Q O2   1 
HETATM 16439 O O3    . SO4 N  2 .   ? 26.816  41.819  12.857  1.00 88.36  ? ? 
? ? ? 360 SO4 Q O3   1 
HETATM 16440 O O4    . SO4 N  2 .   ? 29.026  41.501  13.312  1.00 90.05  ? ? 
? ? ? 360 SO4 Q O4   1 
HETATM 16441 S S     . SO4 O  2 .   ? 38.722  69.489  24.681  1.00 90.68  ? ? 
? ? ? 359 SO4 R S    1 
HETATM 16442 O O1    . SO4 O  2 .   ? 37.773  70.505  25.024  1.00 90.20  ? ? 
? ? ? 359 SO4 R O1   1 
HETATM 16443 O O2    . SO4 O  2 .   ? 38.556  69.169  23.308  1.00 90.47  ? ? 
? ? ? 359 SO4 R O2   1 
HETATM 16444 O O3    . SO4 O  2 .   ? 40.055  69.969  24.910  1.00 90.33  ? ? 
? ? ? 359 SO4 R O3   1 
HETATM 16445 O O4    . SO4 O  2 .   ? 38.489  68.321  25.474  1.00 91.08  ? ? 
? ? ? 359 SO4 R O4   1 
HETATM 16446 S S     . SO4 P  2 .   ? 44.586  63.855  25.182  1.00 86.72  ? ? 
? ? ? 360 SO4 R S    1 
HETATM 16447 O O1    . SO4 P  2 .   ? 44.636  64.259  23.818  1.00 86.49  ? ? 
? ? ? 360 SO4 R O1   1 
HETATM 16448 O O2    . SO4 P  2 .   ? 45.821  64.168  25.815  1.00 88.24  ? ? 
? ? ? 360 SO4 R O2   1 
HETATM 16449 O O3    . SO4 P  2 .   ? 43.486  64.475  25.831  1.00 86.66  ? ? 
? ? ? 360 SO4 R O3   1 
HETATM 16450 O O4    . SO4 P  2 .   ? 44.443  62.464  25.363  1.00 86.96  ? ? 
? ? ? 360 SO4 R O4   1 
HETATM 16451 S S     . SO4 Q  2 .   ? 78.685  15.433  51.173  1.00 86.95  ? ? 
? ? ? 359 SO4 A S    1 
HETATM 16452 O O1    . SO4 Q  2 .   ? 79.378  14.233  50.836  1.00 88.35  ? ? 
? ? ? 359 SO4 A O1   1 
HETATM 16453 O O2    . SO4 Q  2 .   ? 78.307  15.369  52.549  1.00 86.46  ? ? 
? ? ? 359 SO4 A O2   1 
HETATM 16454 O O3    . SO4 Q  2 .   ? 79.522  16.557  50.941  1.00 86.90  ? ? 
? ? ? 359 SO4 A O3   1 
HETATM 16455 O O4    . SO4 Q  2 .   ? 77.523  15.565  50.358  1.00 88.00  ? ? 
? ? ? 359 SO4 A O4   1 
HETATM 16456 S S     . SO4 S  2 .   ? 75.033  22.691  50.637  1.00 85.17  ? ? 
? ? ? 360 SO4 A S    1 
HETATM 16457 O O1    . SO4 S  2 .   ? 75.409  22.623  52.005  1.00 85.19  ? ? 
? ? ? 360 SO4 A O1   1 
HETATM 16458 O O2    . SO4 S  2 .   ? 75.691  23.780  49.997  1.00 87.02  ? ? 
? ? ? 360 SO4 A O2   1 
HETATM 16459 O O3    . SO4 S  2 .   ? 75.274  21.455  49.991  1.00 85.75  ? ? 
? ? ? 360 SO4 A O3   1 
HETATM 16460 O O4    . SO4 S  2 .   ? 73.666  22.954  50.448  1.00 89.08  ? ? ? ? ? 360 SO4 A O4   1 
HETATM 16461 S S     . SO4 U  2 .   ? 49.661  5.398   61.403  1.00 93.89  ? ? ? ? ? 359 SO4 B S    1 
HETATM 16462 O O1    . SO4 U  2 .   ? 49.865  4.017   61.737  1.00 93.72  ? ? 
? ? ? 359 SO4 B O1   1 
HETATM 16463 O O2    . SO4 U  2 .   ? 50.003  5.597   60.029  1.00 92.98  ? ? 
? ? ? 359 SO4 B O2   1 
HETATM 16464 O O3    . SO4 U  2 .   ? 48.302  5.765   61.626  1.00 93.43  ? ? 
? ? ? 359 SO4 B O3   1 
HETATM 16465 O O4    . SO4 U  2 .   ? 50.495  6.218   62.236  1.00 94.21  ? ? 
? ? ? 359 SO4 B O4   1 
HETATM 16466 S S     . SO4 W  2 .   ? 48.065  13.373  61.977  1.00 86.30  ? ? 
? ? ? 360 SO4 B S    1 
HETATM 16467 O O1    . SO4 W  2 .   ? 47.831  13.083  60.607  1.00 85.72  ? ? 
? ? ? 360 SO4 B O1   1 
HETATM 16468 O O2    . SO4 W  2 .   ? 46.871  13.818  62.620  1.00 85.98  ? ? 
? ? ? 360 SO4 B O2   1 
HETATM 16469 O O3    . SO4 W  2 .   ? 48.635  12.235  62.620  1.00 87.91  ? ? 
? ? ? 360 SO4 B O3   1 
HETATM 16470 O O4    . SO4 W  2 .   ? 49.001  14.415  62.173  1.00 87.59  ? ? ? ? ? 360 SO4 B O4   1 
HETATM 16471 P AP    . NAD Y  3 .   ? 28.335  81.526  10.653  1.00 31.02  ? ? ? ? ? 361 NAD O AP   1 
HETATM 16472 O AO1   . NAD Y  3 .   ? 28.849  81.578  12.042  1.00 29.45  ? ? 
? ? ? 361 NAD O AO1  1 
HETATM 16473 O AO2   . NAD Y  3 .   ? 28.287  80.221  9.952   1.00 30.20  ? ? 
? ? ? 361 NAD O AO2  1 
HETATM 16474 O AO5*  . NAD Y  3 .   ? 29.167  82.479  9.647   1.00 30.66  ? ? 
? ? ? 361 NAD O AO5* 1 
HETATM 16475 C AC5*  . NAD Y  3 .   ? 29.766  83.724  10.035  1.00 28.30  ? ? 
? ? ? 361 NAD O AC5* 1 
HETATM 16476 C AC4*  . NAD Y  3 .   ? 31.082  83.826  9.278   1.00 27.73  ? ? 
? ? ? 361 NAD O AC4* 1 
HETATM 16477 O AO4*  . NAD Y  3 .   ? 31.677  85.124  9.424   1.00 28.53  ? ? 
? ? ? 361 NAD O AO4* 1 
HETATM 16478 C AC3*  . NAD Y  3 .   ? 32.112  82.821  9.774   1.00 27.45  ? ? 
? ? ? 361 NAD O AC3* 1 
HETATM 16479 O AO3*  . NAD Y  3 .   ? 32.657  82.077  8.680   1.00 28.92  ? ? 
? ? ? 361 NAD O AO3* 1 
HETATM 16480 C AC2*  . NAD Y  3 .   ? 33.221  83.665  10.368  1.00 27.84  ? ? 
? ? ? 361 NAD O AC2* 1 
HETATM 16481 O AO2*  . NAD Y  3 .   ? 34.487  83.020  10.176  1.00 25.38  ? ? 
? ? ? 361 NAD O AO2* 1 
HETATM 16482 C AC1*  . NAD Y  3 .   ? 33.076  84.886  9.500   1.00 29.26  ? ? 
? ? ? 361 NAD O AC1* 1 
HETATM 16483 N AN9   . NAD Y  3 .   ? 33.818  86.048  10.001  1.00 32.25  ? ? 
? ? ? 361 NAD O AN9  1 
HETATM 16484 C AC8   . NAD Y  3 .   ? 33.704  86.593  11.226  1.00 30.49  ? ? 
? ? ? 361 NAD O AC8  1 
HETATM 16485 N AN7   . NAD Y  3 .   ? 34.290  87.796  11.272  1.00 29.57  ? ? 
? ? ? 361 NAD O AN7  1 
HETATM 16486 C AC5   . NAD Y  3 .   ? 34.787  87.950  10.054  1.00 31.37  ? ? 
? ? ? 361 NAD O AC5  1 
HETATM 16487 C AC6   . NAD Y  3 .   ? 35.276  89.164  9.611   1.00 31.15  ? ? 
? ? ? 361 NAD O AC6  1 
HETATM 16488 N AN6   . NAD Y  3 .   ? 35.402  90.173  10.456  1.00 32.07  ? ? 
? ? ? 361 NAD O AN6  1 
HETATM 16489 N AN1   . NAD Y  3 .   ? 35.527  89.252  8.294   1.00 31.63  ? ? 
? ? ? 361 NAD O AN1  1 
HETATM 16490 C AC2   . NAD Y  3 .   ? 35.309  88.184  7.512   1.00 33.54  ? ? 
? ? ? 361 NAD O AC2  1 
HETATM 16491 N AN3   . NAD Y  3 .   ? 34.825  87.005  7.926   1.00 33.10  ? ? 
? ? ? 361 NAD O AN3  1 
HETATM 16492 C AC4   . NAD Y  3 .   ? 34.523  86.877  9.232   1.00 32.38  ? ? 
? ? ? 361 NAD O AC4  1 
HETATM 16493 O O3    . NAD Y  3 .   ? 26.895  82.230  10.706  1.00 33.74  ? ? 
? ? ? 361 NAD O O3   1 
HETATM 16494 P NP    . NAD Y  3 .   ? 25.575  82.281  9.801   1.00 35.68  ? ? 
? ? ? 361 NAD O NP   1 
HETATM 16495 O NO1   . NAD Y  3 .   ? 24.692  81.206  10.335  1.00 35.27  ? ? 
? ? ? 361 NAD O NO1  1 
HETATM 16496 O NO2   . NAD Y  3 .   ? 25.954  82.319  8.362   1.00 35.59  ? ? 
? ? ? 361 NAD O NO2  1 
HETATM 16497 O NO5*  . NAD Y  3 .   ? 24.880  83.675  10.202  1.00 34.98  ? ? 
? ? ? 361 NAD O NO5* 1 
HETATM 16498 C NC5*  . NAD Y  3 .   ? 25.441  84.936  9.798   1.00 32.91  ? ? 
? ? ? 361 NAD O NC5* 1 
HETATM 16499 C NC4*  . NAD Y  3 .   ? 24.353  85.991  9.789   1.00 32.23  ? ? 
? ? ? 361 NAD O NC4* 1 
HETATM 16500 O NO4*  . NAD Y  3 .   ? 23.362  85.433  8.908   1.00 33.70  ? ? 
? ? ? 361 NAD O NO4* 1 
HETATM 16501 C NC3*  . NAD Y  3 .   ? 23.704  86.137  11.166  1.00 32.11  ? ? 
? ? ? 361 NAD O NC3* 1 
HETATM 16502 O NO3*  . NAD Y  3 .   ? 23.425  87.484  11.557  1.00 31.25  ? ? 
? ? ? 361 NAD O NO3* 1 
HETATM 16503 C NC2*  . NAD Y  3 .   ? 22.414  85.346  11.061  1.00 31.20  ? ? 
? ? ? 361 NAD O NC2* 1 
HETATM 16504 O NO2*  . NAD Y  3 .   ? 21.395  85.947  11.839  1.00 32.58  ? ? 
? ? ? 361 NAD O NO2* 1 
HETATM 16505 C NC1*  . NAD Y  3 .   ? 22.091  85.444  9.595   1.00 32.34  ? ? 
? ? ? 361 NAD O NC1* 1 
HETATM 16506 N NN1   . NAD Y  3 .   ? 21.164  84.382  9.136   1.00 32.72  ? ? 
? ? ? 361 NAD O NN1  1 
HETATM 16507 C NC2   . NAD Y  3 .   ? 21.396  83.013  9.344   1.00 31.75  ? ? 
? ? ? 361 NAD O NC2  1 
HETATM 16508 C NC3   . NAD Y  3 .   ? 20.413  82.082  9.017   1.00 30.99  ? ? 
? ? ? 361 NAD O NC3  1 
HETATM 16509 C NC7   . NAD Y  3 .   ? 20.578  80.613  9.585   1.00 31.80  ? ? 
? ? ? 361 NAD O NC7  1 
HETATM 16510 O NO7   . NAD Y  3 .   ? 19.626  80.052  10.125  1.00 33.99  ? ? 
? ? ? 361 NAD O NO7  1 
HETATM 16511 N NN7   . NAD Y  3 .   ? 21.710  79.974  9.319   1.00 31.13  ? ? 
? ? ? 361 NAD O NN7  1 
HETATM 16512 C NC4   . NAD Y  3 .   ? 19.232  82.491  8.418   1.00 31.70  ? ? 
? ? ? 361 NAD O NC4  1 
HETATM 16513 C NC5   . NAD Y  3 .   ? 19.003  83.839  8.205   1.00 31.99  ? ? 
? ? ? 361 NAD O NC5  1 
HETATM 16514 C NC6   . NAD Y  3 .   ? 19.957  84.785  8.565   1.00 32.28  ? ?  ? ? ? 361 NAD O NC6  1 
HETATM 16515 P AP    . NAD Z  3 .   ? 6.213   51.113  28.431  1.00 32.28  ? ?  ? ? ? 361 NAD P AP   1 
HETATM 16516 O AO1   . NAD Z  3 .   ? 6.273   50.568  27.047  1.00 29.84  ? ?  ? ? ? 361 NAD P AO1  1 
HETATM 16517 O AO2   . NAD Z  3 .   ? 7.431   51.616  29.116  1.00 29.25  ? ?  ? ? ? 361 NAD P AO2  1 
HETATM 16518 O AO5*  . NAD Z  3 .   ? 5.631   49.989  29.431  1.00 31.50  ? ? 
? ? ? 361 NAD P AO5* 1 
HETATM 16519 C AC5*  . NAD Z  3 .   ? 4.615   49.052  29.040  1.00 28.54  ? ? 
? ? ? 361 NAD P AC5* 1 
HETATM 16520 C AC4*  . NAD Z  3 .   ? 4.932   47.787  29.803  1.00 27.10  ? ? 
? ? ? 361 NAD P AC4* 1 
HETATM 16521 O AO4*  . NAD Z  3 .   ? 3.876   46.835  29.649  1.00 28.85  ? ? 
? ? ? 361 NAD P AO4* 1 
HETATM 16522 C AC3*  . NAD Z  3 .   ? 6.200   47.125  29.284  1.00 26.93  ? ? 
? ? ? 361 NAD P AC3* 1 
HETATM 16523 O AO3*  . NAD Z  3 .   ? 7.082   46.834  30.365  1.00 28.28  ? ? 
? ? ? 361 NAD P AO3* 1 
HETATM 16524 C AC2*  . NAD Z  3 .   ? 5.726   45.806  28.700  1.00 28.10  ? ? 
? ? ? 361 NAD P AC2* 1 
HETATM 16525 O AO2*  . NAD Z  3 .   ? 6.722   44.801  28.874  1.00 26.70  ? ? 
? ? ? 361 NAD P AO2* 1 
HETATM 16526 C AC1*  . NAD Z  3 .   ? 4.515   45.547  29.562  1.00 29.30  ? ? 
? ? ? 361 NAD P AC1* 1 
HETATM 16527 N AN9   . NAD Z  3 .   ? 3.662   44.452  29.064  1.00 29.40  ? ? 
? ? ? 361 NAD P AN9  1 
HETATM 16528 C AC8   . NAD Z  3 .   ? 3.093   44.413  27.846  1.00 29.46  ? ? 
? ? ? 361 NAD P AC8  1 
HETATM 16529 N AN7   . NAD Z  3 .   ? 2.113   43.503  27.814  1.00 30.28  ? ? 
? ? ? 361 NAD P AN7  1 
HETATM 16530 C AC5   . NAD Z  3 .   ? 2.132   42.977  29.026  1.00 29.10  ? ? 
? ? ? 361 NAD P AC5  1 
HETATM 16531 C AC6   . NAD Z  3 .   ? 1.116   42.150  29.453  1.00 29.61  ? ? 
? ? ? 361 NAD P AC6  1 
HETATM 16532 N AN6   . NAD Z  3 .   ? 0.179   41.725  28.606  1.00 30.80  ? ? 
? ? ? 361 NAD P AN6  1 
HETATM 16533 N AN1   . NAD Z  3 .   ? 1.128   41.887  30.768  1.00 30.90  ? ? 
? ? ? 361 NAD P AN1  1 
HETATM 16534 C AC2   . NAD Z  3 .   ? 2.094   42.414  31.537  1.00 31.56  ? ? 
? ? ? 361 NAD P AC2  1 
HETATM 16535 N AN3   . NAD Z  3 .   ? 3.076   43.223  31.133  1.00 27.99  ? ? 
? ? ? 361 NAD P AN3  1 
HETATM 16536 C AC4   . NAD Z  3 .   ? 3.088   43.538  29.835  1.00 28.17  ? ? 
? ? ? 361 NAD P AC4  1 
HETATM 16537 O O3    . NAD Z  3 .   ? 5.129   52.267  28.366  1.00 32.49  ? ? 
? ? ? 361 NAD P O3   1 
HETATM 16538 P NP    . NAD Z  3 .   ? 4.714   53.491  29.285  1.00 33.60  ? ? 
? ? ? 361 NAD P NP   1 
HETATM 16539 O NO1   . NAD Z  3 .   ? 5.478   54.651  28.757  1.00 34.08  ? ? 
? ? ? 361 NAD P NO1  1 
HETATM 16540 O NO2   . NAD Z  3 .   ? 4.780   53.126  30.725  1.00 33.43  ? ? 
? ? ? 361 NAD P NO2  1 
HETATM 16541 O NO5*  . NAD Z  3 .   ? 3.169   53.717  28.885  1.00 34.44  ? ? 
? ? ? 361 NAD P NO5* 1 
HETATM 16542 C NC5*  . NAD Z  3 .   ? 2.131   52.808  29.289  1.00 32.16  ? ? 
? ? ? 361 NAD P NC5* 1 
HETATM 16543 C NC4*  . NAD Z  3 .   ? 0.782   53.526  29.312  1.00 32.24  ? ? 
? ? ? 361 NAD P NC4* 1 
HETATM 16544 O NO4*  . NAD Z  3 .   ? 0.985   54.642  30.191  1.00 34.39  ? ? 
? ? ? 361 NAD P NO4* 1 
HETATM 16545 C NC3*  . NAD Z  3 .   ? 0.427   54.099  27.945  1.00 32.24  ? ? 
? ? ? 361 NAD P NC3* 1 
HETATM 16546 O NO3*  . NAD Z  3 .   ? -0.947  53.962  27.568  1.00 30.33  ? ? 
? ? ? 361 NAD P NO3* 1 
HETATM 16547 C NC2*  . NAD Z  3 .   ? 0.779   55.570  28.048  1.00 33.76  ? ? 
? ? ? 361 NAD P NC2* 1 
HETATM 16548 O NO2*  . NAD Z  3 .   ? -0.123  56.354  27.248  1.00 36.18  ? ? 
? ? ? 361 NAD P NO2* 1 
HETATM 16549 C NC1*  . NAD Z  3 .   ? 0.614   55.852  29.519  1.00 33.69  ? ? 
? ? ? 361 NAD P NC1* 1 
HETATM 16550 N NN1   . NAD Z  3 .   ? 1.365   57.045  29.976  1.00 33.67  ? ? 
? ? ? 361 NAD P NN1  1 
HETATM 16551 C NC2   . NAD Z  3 .   ? 2.737   57.230  29.757  1.00 32.92  ? ? 
? ? ? 361 NAD P NC2  1 
HETATM 16552 C NC3   . NAD Z  3 .   ? 3.336   58.441  30.083  1.00 32.98  ? ? 
? ? ? 361 NAD P NC3  1 
HETATM 16553 C NC7   . NAD Z  3 .   ? 4.799   58.741  29.581  1.00 31.42  ? ? 
? ? ? 361 NAD P NC7  1 
HETATM 16554 O NO7   . NAD Z  3 .   ? 5.046   59.822  29.049  1.00 31.50  ? ? 
? ? ? 361 NAD P NO7  1 
HETATM 16555 N NN7   . NAD Z  3 .   ? 5.751   57.854  29.843  1.00 31.81  ? ? 
? ? ? 361 NAD P NN7  1 
HETATM 16556 C NC4   . NAD Z  3 .   ? 2.583   59.430  30.705  1.00 34.91  ? ? 
? ? ? 361 NAD P NC4  1 
HETATM 16557 C NC5   . NAD Z  3 .   ? 1.229   59.251  30.926  1.00 36.11  ? ? 
? ? ? 361 NAD P NC5  1 
HETATM 16558 C NC6   . NAD Z  3 .   ? 0.615   58.067  30.545  1.00 35.61  ? ? 
? ? ? 361 NAD P NC6  1 
HETATM 16559 P AP    . NAD AA 3 .   ? 13.451  46.133  9.952   1.00 34.76  ? ? 
? ? ? 361 NAD Q AP   1 
HETATM 16560 O AO1   . NAD AA 3 .   ? 12.941  46.029  11.345  1.00 33.35  ? ? 
? ? ? 361 NAD Q AO1  1 
HETATM 16561 O AO2   . NAD AA 3 .   ? 13.541  47.466  9.313   1.00 30.25  ? ? 
? ? ? 361 NAD Q AO2  1 
HETATM 16562 O AO5*  . NAD AA 3 .   ? 12.628  45.219  8.920   1.00 30.15  ? ? 
? ? ? 361 NAD Q AO5* 1 
HETATM 16563 C AC5*  . NAD AA 3 .   ? 12.077  43.948  9.261   1.00 30.81  ? ? 
? ? ? 361 NAD Q AC5* 1 
HETATM 16564 C AC4*  . NAD AA 3 .   ? 10.768  43.881  8.494   1.00 32.85  ? ? 
? ? ? 361 NAD Q AC4* 1 
HETATM 16565 O AO4*  . NAD AA 3 .   ? 10.168  42.575  8.590   1.00 33.03  ? ? 
? ? ? 361 NAD Q AO4* 1 
HETATM 16566 C AC3*  . NAD AA 3 .   ? 9.726   44.878  9.027   1.00 33.54  ? ? 
? ? ? 361 NAD Q AC3* 1 
HETATM 16567 O AO3*  . NAD AA 3 .   ? 9.175   45.660  7.952   1.00 33.28  ? ? 
? ? ? 361 NAD Q AO3* 1 
HETATM 16568 C AC2*  . NAD AA 3 .   ? 8.617   44.001  9.585   1.00 32.53  ? ? 
? ? ? 361 NAD Q AC2* 1 
HETATM 16569 O AO2*  . NAD AA 3 .   ? 7.356   44.642  9.358   1.00 32.00  ? ? 
? ? ? 361 NAD Q AO2* 1 
HETATM 16570 C AC1*  . NAD AA 3 .   ? 8.758   42.803  8.672   1.00 32.37  ? ? 
? ? ? 361 NAD Q AC1* 1 
HETATM 16571 N AN9   . NAD AA 3 .   ? 7.999   41.633  9.118   1.00 31.12  ? ? 
? ? ? 361 NAD Q AN9  1 
HETATM 16572 C AC8   . NAD AA 3 .   ? 8.105   41.047  10.319  1.00 31.76  ? ? 
? ? ? 361 NAD Q AC8  1 
HETATM 16573 N AN7   . NAD AA 3 .   ? 7.524   39.840  10.323  1.00 31.40  ? ? 
? ? ? 361 NAD Q AN7  1 
HETATM 16574 C AC5   . NAD AA 3 .   ? 7.059   39.719  9.092   1.00 30.84  ? ? 
? ? ? 361 NAD Q AC5  1 
HETATM 16575 C AC6   . NAD AA 3 .   ? 6.600   38.506  8.605   1.00 30.09  ? ? 
? ? ? 361 NAD Q AC6  1 
HETATM 16576 N AN6   . NAD AA 3 .   ? 6.445   37.476  9.422   1.00 28.15  ? ? 
? ? ? 361 NAD Q AN6  1 
HETATM 16577 N AN1   . NAD AA 3 .   ? 6.371   38.460  7.279   1.00 30.59  ? ? 
? ? ? 361 NAD Q AN1  1 
HETATM 16578 C AC2   . NAD AA 3 .   ? 6.575   39.565  6.541   1.00 32.31  ? ? 
? ? ? 361 NAD Q AC2  1 
HETATM 16579 N AN3   . NAD AA 3 .   ? 7.033   40.740  6.999   1.00 31.63  ? ? 
? ? ? 361 NAD Q AN3  1 
HETATM 16580 C AC4   . NAD AA 3 .   ? 7.318   40.825  8.314   1.00 31.40  ? ? 
? ? ? 361 NAD Q AC4  1 
HETATM 16581 O O3    . NAD AA 3 .   ? 14.933  45.426  10.020  1.00 38.83  ? ? 
? ? ? 361 NAD Q O3   1 
HETATM 16582 P NP    . NAD AA 3 .   ? 16.313  45.398  9.158   1.00 37.87  ? ? 
? ? ? 361 NAD Q NP   1 
HETATM 16583 O NO1   . NAD AA 3 .   ? 17.162  46.475  9.727   1.00 36.79  ? ? 
? ? ? 361 NAD Q NO1  1 
HETATM 16584 O NO2   . NAD AA 3 .   ? 15.938  45.410  7.713   1.00 37.58  ? ? 
? ? ? 361 NAD Q NO2  1 
HETATM 16585 O NO5*  . NAD AA 3 .   ? 16.988  43.991  9.540   1.00 34.27  ? ? 
? ? ? 361 NAD Q NO5* 1 
HETATM 16586 C NC5*  . NAD AA 3 .   ? 16.415  42.749  9.089   1.00 34.10  ? ? 
? ? ? 361 NAD Q NC5* 1 
HETATM 16587 C NC4*  . NAD AA 3 .   ? 17.493  41.676  9.022   1.00 32.51  ? ? 
? ? ? 361 NAD Q NC4* 1 
HETATM 16588 O NO4*  . NAD AA 3 .   ? 18.503  42.218  8.147   1.00 32.98  ? ? 
? ? ? 361 NAD Q NO4* 1 
HETATM 16589 C NC3*  . NAD AA 3 .   ? 18.101  41.489  10.401  1.00 31.47  ? ? 
? ? ? 361 NAD Q NC3* 1 
HETATM 16590 O NO3*  . NAD AA 3 .   ? 18.362  40.133  10.749  1.00 29.00  ? ? 
? ? ? 361 NAD Q NO3* 1 
HETATM 16591 C NC2*  . NAD AA 3 .   ? 19.403  42.272  10.331  1.00 33.01  ? ? 
? ? ? 361 NAD Q NC2* 1 
HETATM 16592 O NO2*  . NAD AA 3 .   ? 20.413  41.643  11.126  1.00 34.40  ? ? 
? ? ? 361 NAD Q NO2* 1 
HETATM 16593 C NC1*  . NAD AA 3 .   ? 19.753  42.222  8.858   1.00 33.77  ? ? 
? ? ? 361 NAD Q NC1* 1 
HETATM 16594 N NN1   . NAD AA 3 .   ? 20.687  43.306  8.454   1.00 34.16  ? ? 
? ? ? 361 NAD Q NN1  1 
HETATM 16595 C NC2   . NAD AA 3 .   ? 20.448  44.673  8.705   1.00 33.37  ? ? 
? ? ? 361 NAD Q NC2  1 
HETATM 16596 C NC3   . NAD AA 3 .   ? 21.427  45.624  8.414   1.00 32.30  ? ? 
? ? ? 361 NAD Q NC3  1 
HETATM 16597 C NC7   . NAD AA 3 .   ? 21.263  47.069  9.032   1.00 32.19  ? ? 
? ? ? 361 NAD Q NC7  1 
HETATM 16598 O NO7   . NAD AA 3 .   ? 22.208  47.613  9.602   1.00 31.21  ? ? 
? ? ? 361 NAD Q NO7  1 
HETATM 16599 N NN7   . NAD AA 3 .   ? 20.133  47.717  8.772   1.00 35.32  ? ? 
? ? ? 361 NAD Q NN7  1 
HETATM 16600 C NC4   . NAD AA 3 .   ? 22.613  45.225  7.821   1.00 31.96  ? ? 
? ? ? 361 NAD Q NC4  1 
HETATM 16601 C NC5   . NAD AA 3 .   ? 22.852  43.886  7.574   1.00 32.46  ? ? 
? ? ? 361 NAD Q NC5  1 
HETATM 16602 C NC6   . NAD AA 3 .   ? 21.901  42.926  7.893   1.00 33.15  ? ? 
? ? ? 361 NAD Q NC6  1 
HETATM 16603 P AP    . NAD BA 3 .   ? 35.418  75.846  28.862  1.00 31.09  ? ? 
? ? ? 361 NAD R AP   1 
HETATM 16604 O AO1   . NAD BA 3 .   ? 35.364  76.400  27.482  1.00 29.90  ? ? 
? ? ? 361 NAD R AO1  1 
HETATM 16605 O AO2   . NAD BA 3 .   ? 34.202  75.381  29.576  1.00 30.64  ? ? 
? ? ? 361 NAD R AO2  1 
HETATM 16606 O AO5*  . NAD BA 3 .   ? 36.010  76.921  29.894  1.00 33.88  ? ? 
? ? ? 361 NAD R AO5* 1 
HETATM 16607 C AC5*  . NAD BA 3 .   ? 37.030  77.885  29.557  1.00 32.17  ? ? 
? ? ? 361 NAD R AC5* 1 
HETATM 16608 C AC4*  . NAD BA 3 .   ? 36.710  79.151  30.352  1.00 31.37  ? ? 
? ? ? 361 NAD R AC4* 1 
HETATM 16609 O AO4*  . NAD BA 3 .   ? 37.759  80.119  30.233  1.00 31.40  ? ? 
? ? ? 361 NAD R AO4* 1 
HETATM 16610 C AC3*  . NAD BA 3 .   ? 35.449  79.859  29.860  1.00 29.98  ? ? 
? ? ? 361 NAD R AC3* 1 
HETATM 16611 O AO3*  . NAD BA 3 .   ? 34.561  80.131  30.970  1.00 30.55  ? ? 
? ? ? 361 NAD R AO3* 1 
HETATM 16612 C AC2*  . NAD BA 3 .   ? 35.941  81.152  29.254  1.00 27.04  ? ? 
? ? ? 361 NAD R AC2* 1 
HETATM 16613 O AO2*  . NAD BA 3 .   ? 34.917  82.125  29.437  1.00 26.26  ? ? 
? ? ? 361 NAD R AO2* 1 
HETATM 16614 C AC1*  . NAD BA 3 .   ? 37.116  81.384  30.162  1.00 28.17  ? ? 
? ? ? 361 NAD R AC1* 1 
HETATM 16615 N AN9   . NAD BA 3 .   ? 38.015  82.449  29.727  1.00 27.94  ? ? 
? ? ? 361 NAD R AN9  1 
HETATM 16616 C AC8   . NAD BA 3 .   ? 38.583  82.541  28.518  1.00 28.88  ? ? 
? ? ? 361 NAD R AC8  1 
HETATM 16617 N AN7   . NAD BA 3 .   ? 39.545  83.467  28.499  1.00 28.54  ? ? 
? ? ? 361 NAD R AN7  1 
HETATM 16618 C AC5   . NAD BA 3 .   ? 39.530  83.934  29.740  1.00 30.33  ? ? 
? ? ? 361 NAD R AC5  1 
HETATM 16619 C AC6   . NAD BA 3 .   ? 40.536  84.752  30.222  1.00 31.19  ? ? 
? ? ? 361 NAD R AC6  1 
HETATM 16620 N AN6   . NAD BA 3 .   ? 41.471  85.202  29.392  1.00 31.98  ? ? 
? ? ? 361 NAD R AN6  1 
HETATM 16621 N AN1   . NAD BA 3 .   ? 40.517  84.998  31.543  1.00 31.33  ? ? 
? ? ? 361 NAD R AN1  1 
HETATM 16622 C AC2   . NAD BA 3 .   ? 39.553  84.452  32.283  1.00 31.83  ? ? 
? ? ? 361 NAD R AC2  1 
HETATM 16623 N AN3   . NAD BA 3 .   ? 38.597  83.644  31.823  1.00 29.61  ? ? 
? ? ? 361 NAD R AN3  1 
HETATM 16624 C AC4   . NAD BA 3 .   ? 38.581  83.342  30.524  1.00 28.61  ? ? 
? ? ? 361 NAD R AC4  1 
HETATM 16625 O O3    . NAD BA 3 .   ? 36.499  74.695  28.792  1.00 32.15  ? ? 
? ? ? 361 NAD R O3   1 
HETATM 16626 P NP    . NAD BA 3 .   ? 36.901  73.444  29.681  1.00 32.48  ? ? 
? ? ? 361 NAD R NP   1 
HETATM 16627 O NO1   . NAD BA 3 .   ? 36.147  72.284  29.150  1.00 33.84  ? ? 
? ? ? 361 NAD R NO1  1 
HETATM 16628 O NO2   . NAD BA 3 .   ? 36.760  73.811  31.106  1.00 33.00  ? ? 
? ? ? 361 NAD R NO2  1 
HETATM 16629 O NO5*  . NAD BA 3 .   ? 38.448  73.193  29.285  1.00 31.83  ? ? 
? ? ? 361 NAD R NO5* 1 
HETATM 16630 C NC5*  . NAD BA 3 .   ? 39.475  74.108  29.704  1.00 32.28  ? ? 
? ? ? 361 NAD R NC5* 1 
HETATM 16631 C NC4*  . NAD BA 3 .   ? 40.823  73.385  29.747  1.00 31.95  ? ? 
? ? ? 361 NAD R NC4* 1 
HETATM 16632 O NO4*  . NAD BA 3 .   ? 40.588  72.245  30.590  1.00 32.67  ? ? 
? ? ? 361 NAD R NO4* 1 
HETATM 16633 C NC3*  . NAD BA 3 .   ? 41.207  72.862  28.377  1.00 31.94  ? ? 
? ? ? 361 NAD R NC3* 1 
HETATM 16634 O NO3*  . NAD BA 3 .   ? 42.593  73.018  28.050  1.00 27.62  ? ? 
? ? ? 361 NAD R NO3* 1 
HETATM 16635 C NC2*  . NAD BA 3 .   ? 40.814  71.394  28.418  1.00 32.22  ? ? 
? ? ? 361 NAD R NC2* 1 
HETATM 16636 O NO2*  . NAD BA 3 .   ? 41.715  70.644  27.591  1.00 33.11  ? ? 
? ? ? 361 NAD R NO2* 1 
HETATM 16637 C NC1*  . NAD BA 3 .   ? 40.973  71.068  29.885  1.00 32.11  ? ? 
? ? ? 361 NAD R NC1* 1 
HETATM 16638 N NN1   . NAD BA 3 .   ? 40.233  69.864  30.325  1.00 30.79  ? ? 
? ? ? 361 NAD R NN1  1 
HETATM 16639 C NC2   . NAD BA 3 .   ? 38.863  69.703  30.102  1.00 32.80  ? ? 
? ? ? 361 NAD R NC2  1 
HETATM 16640 C NC3   . NAD BA 3 .   ? 38.264  68.470  30.381  1.00 34.88  ? ? 
? ? ? 361 NAD R NC3  1 
HETATM 16641 C NC7   . NAD BA 3 .   ? 36.836  68.175  29.767  1.00 34.40  ? ? 
? ? ? 361 NAD R NC7  1 
HETATM 16642 O NO7   . NAD BA 3 .   ? 36.598  67.111  29.196  1.00 33.77  ? ? 
? ? ? 361 NAD R NO7  1 
HETATM 16643 N NN7   . NAD BA 3 .   ? 35.879  69.054  30.039  1.00 35.45  ? ? 
? ? ? 361 NAD R NN7  1 
HETATM 16644 C NC4   . NAD BA 3 .   ? 39.030  67.456  30.957  1.00 33.63  ? ? 
? ? ? 361 NAD R NC4  1 
HETATM 16645 C NC5   . NAD BA 3 .   ? 40.385  67.614  31.172  1.00 30.39  ? ? 
? ? ? 361 NAD R NC5  1 
HETATM 16646 C NC6   . NAD BA 3 .   ? 40.984  68.812  30.845  1.00 30.48  ? ? 
? ? ? 361 NAD R NC6  1 
HETATM 16647 P AP    . NAD CA 3 .   ? 83.824  10.394  47.105  1.00 34.76  ? ? 
? ? ? 361 NAD A AP   1 
HETATM 16648 O AO1   . NAD CA 3 .   ? 84.330  10.168  48.483  1.00 32.73  ? ? 
? ? ? 361 NAD A AO1  1 
HETATM 16649 O AO2   . NAD CA 3 .   ? 82.991  9.340   46.460  1.00 32.33  ? ? 
? ? ? 361 NAD A AO2  1 
HETATM 16650 O AO5*  . NAD CA 3 .   ? 85.072  10.648  46.065  1.00 34.43  ? ? 
? ? ? 361 NAD A AO5* 1 
HETATM 16651 C AC5*  . NAD CA 3 .   ? 86.262  11.355  46.400  1.00 31.55  ? ? 
? ? ? 361 NAD A AC5* 1 
HETATM 16652 C AC4*  . NAD CA 3 .   ? 87.354  10.669  45.611  1.00 32.60  ? ? 
? ? ? 361 NAD A AC4* 1 
HETATM 16653 O AO4*  . NAD CA 3 .   ? 88.601  11.400  45.733  1.00 33.97  ? ? 
? ? ? 361 NAD A AO4* 1 
HETATM 16654 C AC3*  . NAD CA 3 .   ? 87.635  9.258   46.136  1.00 31.42  ? ? 
? ? ? 361 NAD A AC3* 1 
HETATM 16655 O AO3*  . NAD CA 3 .   ? 87.638  8.322   45.051  1.00 33.59  ? ? 
? ? ? 361 NAD A AO3* 1 
HETATM 16656 C AC2*  . NAD CA 3 .   ? 89.055  9.335   46.699  1.00 31.67  ? ? 
? ? ? 361 NAD A AC2* 1 
HETATM 16657 O AO2*  . NAD CA 3 .   ? 89.729  8.085   46.512  1.00 28.27  ? ? 
? ? ? 361 NAD A AO2* 1 
HETATM 16658 C AC1*  . NAD CA 3 .   ? 89.639  10.417  45.809  1.00 31.85  ? ? 
? ? ? 361 NAD A AC1* 1 
HETATM 16659 N AN9   . NAD CA 3 .   ? 90.918  10.958  46.264  1.00 29.64  ? ? 
? ? ? 361 NAD A AN9  1 
HETATM 16660 C AC8   . NAD CA 3 .   ? 91.148  11.477  47.474  1.00 29.08  ? ? 
? ? ? 361 NAD A AC8  1 
HETATM 16661 N AN7   . NAD CA 3 .   ? 92.309  12.137  47.490  1.00 30.27  ? ? 
? ? ? 361 NAD A AN7  1 
HETATM 16662 C AC5   . NAD CA 3 .   ? 92.766  11.998  46.253  1.00 29.77  ? ? 
? ? ? 361 NAD A AC5  1 
HETATM 16663 C AC6   . NAD CA 3 .   ? 93.835  12.734  45.783  1.00 29.74  ? ? 
? ? ? 361 NAD A AC6  1 
HETATM 16664 N AN6   . NAD CA 3 .   ? 94.536  13.496  46.614  1.00 30.93  ? ? 
? ? ? 361 NAD A AN6  1 
HETATM 16665 N AN1   . NAD CA 3 .   ? 94.081  12.633  44.473  1.00 28.43  ? ? 
? ? ? 361 NAD A AN1  1 
HETATM 16666 C AC2   . NAD CA 3 .   ? 93.297  11.845  43.735  1.00 30.88  ? ? 
? ? ? 361 NAD A AC2  1 
HETATM 16667 N AN3   . NAD CA 3 .   ? 92.247  11.148  44.172  1.00 30.08  ? ? 
? ? ? 361 NAD A AN3  1 
HETATM 16668 C AC4   . NAD CA 3 .   ? 91.940  11.241  45.470  1.00 29.95  ? ? 
? ? ? 361 NAD A AC4  1 
HETATM 16669 O O3    . NAD CA 3 .   ? 83.035  11.785  47.145  1.00 32.37  ? ? 
? ? ? 361 NAD A O3   1 
HETATM 16670 P NP    . NAD CA 3 .   ? 81.986  12.557  46.232  1.00 33.00  ? ? 
? ? ? 361 NAD A NP   1 
HETATM 16671 O NO1   . NAD CA 3 .   ? 80.669  12.179  46.775  1.00 35.40  ? ? 
? ? ? 361 NAD A NO1  1 
HETATM 16672 O NO2   . NAD CA 3 .   ? 82.286  12.348  44.800  1.00 32.74  ? ? 
? ? ? 361 NAD A NO2  1 
HETATM 16673 O NO5*  . NAD CA 3 .   ? 82.184  14.095  46.608  1.00 32.54  ? ? 
? ? ? 361 NAD A NO5* 1 
HETATM 16674 C NC5*  . NAD CA 3 .   ? 83.352  14.802  46.187  1.00 32.96  ? ? 
? ? ? 361 NAD A NC5* 1 
HETATM 16675 C NC4*  . NAD CA 3 .   ? 83.071  16.290  46.160  1.00 32.61  ? ? 
? ? ? 361 NAD A NC4* 1 
HETATM 16676 O NO4*  . NAD CA 3 .   ? 81.931  16.386  45.305  1.00 32.74  ? ? 
? ? ? 361 NAD A NO4* 1 
HETATM 16677 C NC3*  . NAD CA 3 .   ? 82.670  16.793  47.538  1.00 32.37  ? ? 
? ? ? 361 NAD A NC3* 1 
HETATM 16678 O NO3*  . NAD CA 3 .   ? 83.224  18.074  47.889  1.00 32.29  ? ? 
? ? ? 361 NAD A NO3* 1 
HETATM 16679 C NC2*  . NAD CA 3 .   ? 81.155  16.871  47.469  1.00 32.77  ? ? 
? ? ? 361 NAD A NC2* 1 
HETATM 16680 O NO2*  . NAD CA 3 .   ? 80.675  17.968  48.269  1.00 35.55  ? ? 
? ? ? 361 NAD A NO2* 1 
HETATM 16681 C NC1*  . NAD CA 3 .   ? 80.903  17.111  45.996  1.00 31.97  ? ? 
? ? ? 361 NAD A NC1* 1 
HETATM 16682 N NN1   . NAD CA 3 .   ? 79.518  16.767  45.567  1.00 31.21  ? ? 
? ? ? 361 NAD A NN1  1 
HETATM 16683 C NC2   . NAD CA 3 .   ? 78.952  15.510  45.798  1.00 30.44  ? ? 
? ? ? 361 NAD A NC2  1 
HETATM 16684 C NC3   . NAD CA 3 .   ? 77.622  15.285  45.492  1.00 31.44  ? ? 
? ? ? 361 NAD A NC3  1 
HETATM 16685 C NC7   . NAD CA 3 .   ? 76.815  13.948  45.755  1.00 35.19  ? ? 
? ? ? 361 NAD A NC7  1 
HETATM 16686 O NO7   . NAD CA 3 .   ? 75.721  14.024  46.311  1.00 35.27  ? ? 
? ? ? 361 NAD A NO7  1 
HETATM 16687 N NN7   . NAD CA 3 .   ? 77.384  12.780  45.482  1.00 38.03  ? ? 
? ? ? 361 NAD A NN7  1 
HETATM 16688 C NC4   . NAD CA 3 .   ? 76.894  16.292  44.898  1.00 30.53  ? ? 
? ? ? 361 NAD A NC4  1 
HETATM 16689 C NC5   . NAD CA 3 .   ? 77.448  17.534  44.668  1.00 29.20  ? ? 
? ? ? 361 NAD A NC5  1 
HETATM 16690 C NC6   . NAD CA 3 .   ? 78.754  17.784  45.009  1.00 29.62  ? ? 
? ? ? 361 NAD A NC6  1 
HETATM 16691 P AP    . NAD EA 3 .   ? 48.692  -1.767  65.473  1.00 26.30  ? ? 
? ? ? 361 NAD B AP   1 
HETATM 16692 O AO1   . NAD EA 3 .   ? 48.474  -2.225  64.090  1.00 25.17  ? ? 
? ? ? 361 NAD B AO1  1 
HETATM 16693 O AO2   . NAD EA 3 .   ? 49.979  -2.092  66.115  1.00 27.96  ? ? 
? ? ? 361 NAD B AO2  1 
HETATM 16694 O AO5*  . NAD EA 3 .   ? 47.592  -2.327  66.501  1.00 22.88  ? ? 
? ? ? 361 NAD B AO5* 1 
HETATM 16695 C AC5*  . NAD EA 3 .   ? 46.227  -2.507  66.155  1.00 23.68  ? ? 
? ? ? 361 NAD B AC5* 1 
HETATM 16696 C AC4*  . NAD EA 3 .   ? 45.766  -3.726  66.922  1.00 26.65  ? ? 
? ? ? 361 NAD B AC4* 1 
HETATM 16697 O AO4*  . NAD EA 3 .   ? 44.337  -3.901  66.817  1.00 28.63  ? ? 
? ? ? 361 NAD B AO4* 1 
HETATM 16698 C AC3*  . NAD EA 3 .   ? 46.410  -5.010  66.411  1.00 25.31  ? ? 
? ? ? 361 NAD B AC3* 1 
HETATM 16699 O AO3*  . NAD EA 3 .   ? 46.945  -5.758  67.499  1.00 25.63  ? ? 
? ? ? 361 NAD B AO3* 1 
HETATM 16700 C AC2*  . NAD EA 3 .   ? 45.254  -5.818  65.851  1.00 27.19  ? ? 
? ? ? 361 NAD B AC2* 1 
HETATM 16701 O AO2*  . NAD EA 3 .   ? 45.482  -7.213  66.038  1.00 25.38  ? ? 
? ? ? 361 NAD B AO2* 1 
HETATM 16702 C AC1*  . NAD EA 3 .   ? 44.130  -5.320  66.731  1.00 28.08  ? ? 
? ? ? 361 NAD B AC1* 1 
HETATM 16703 N AN9   . NAD EA 3 .   ? 42.787  -5.691  66.252  1.00 28.47  ? ? 
? ? ? 361 NAD B AN9  1 
HETATM 16704 C AC8   . NAD EA 3 .   ? 42.285  -5.425  65.036  1.00 28.48  ? ? 
? ? ? 361 NAD B AC8  1 
HETATM 16705 N AN7   . NAD EA 3 .   ? 40.965  -5.610  65.015  1.00 28.39  ? ? 
? ? ? 361 NAD B AN7  1 
HETATM 16706 C AC5   . NAD EA 3 .   ? 40.688  -6.014  66.246  1.00 29.97  ? ? 
? ? ? 361 NAD B AC5  1 
HETATM 16707 C AC6   . NAD EA 3 .   ? 39.387  -6.118  66.713  1.00 29.90  ? ? 
? ? ? 361 NAD B AC6  1 
HETATM 16708 N AN6   . NAD EA 3 .   ? 38.377  -5.943  65.869  1.00 27.06  ? ? 
? ? ? 361 NAD B AN6  1 
HETATM 16709 N AN1   . NAD EA 3 .   ? 39.255  -6.349  68.040  1.00 30.52  ? ? 
? ? ? 361 NAD B AN1  1 
HETATM 16710 C AC2   . NAD EA 3 .   ? 40.351  -6.461  68.804  1.00 31.53  ? ? 
? ? ? 361 NAD B AC2  1 
HETATM 16711 N AN3   . NAD EA 3 .   ? 41.613  -6.339  68.365  1.00 31.22  ? ? 
? ? ? 361 NAD B AN3  1 
HETATM 16712 C AC4   . NAD EA 3 .   ? 41.803  -6.088  67.048  1.00 30.35  ? ? 
? ? ? 361 NAD B AC4  1 
HETATM 16713 O O3    . NAD EA 3 .   ? 48.482  -0.200  65.423  1.00 30.43  ? ? 
? ? ? 361 NAD B O3   1 
HETATM 16714 P NP    . NAD EA 3 .   ? 48.856  1.068   66.321  1.00 33.42  ? ? 
? ? ? 361 NAD B NP   1 
HETATM 16715 O NO1   . NAD EA 3 .   ? 50.141  1.574   65.799  1.00 35.17  ? ? 
? ? ? 361 NAD B NO1  1 
HETATM 16716 O NO2   . NAD EA 3 .   ? 48.746  0.713   67.763  1.00 35.68  ? ? 
? ? ? 361 NAD B NO2  1 
HETATM 16717 O NO5*  . NAD EA 3 .   ? 47.727  2.159   65.941  1.00 33.98  ? ? 
? ? ? 361 NAD B NO5* 1 
HETATM 16718 C NC5*  . NAD EA 3 .   ? 46.364  1.991   66.386  1.00 34.05  ? ? 
? ? ? 361 NAD B NC5* 1 
HETATM 16719 C NC4*  . NAD EA 3 .   ? 45.672  3.340   66.430  1.00 34.86  ? ? 
? ? ? 361 NAD B NC4* 1 
HETATM 16720 O NO4*  . NAD EA 3 .   ? 46.487  4.137   67.304  1.00 36.66  ? ? 
? ? ? 361 NAD B NO4* 1 
HETATM 16721 C NC3*  . NAD EA 3 .   ? 45.690  4.017   65.052  1.00 36.62  ? ? 
? ? ? 361 NAD B NC3* 1 
HETATM 16722 O NO3*  . NAD EA 3 .   ? 44.472  4.697   64.683  1.00 36.62  ? ? 
? ? ? 361 NAD B NO3* 1 
HETATM 16723 C NC2*  . NAD EA 3 .   ? 46.837  5.008   65.128  1.00 35.30  ? ? 
? ? ? 361 NAD B NC2* 1 
HETATM 16724 O NO2*  . NAD EA 3 .   ? 46.534  6.161   64.346  1.00 35.30  ? ? 
? ? ? 361 NAD B NO2* 1 
HETATM 16725 C NC1*  . NAD EA 3 .   ? 46.870  5.336   66.598  1.00 36.18  ? ? 
? ? ? 361 NAD B NC1* 1 
HETATM 16726 N NN1   . NAD EA 3 .   ? 48.179  5.900   67.021  1.00 37.03  ? ? 
? ? ? 361 NAD B NN1  1 
HETATM 16727 C NC2   . NAD EA 3 .   ? 49.409  5.259   66.787  1.00 36.32  ? ? 
? ? ? 361 NAD B NC2  1 
HETATM 16728 C NC3   . NAD EA 3 .   ? 50.598  5.919   67.102  1.00 36.34  ? ? 
? ? ? 361 NAD B NC3  1 
HETATM 16729 C NC7   . NAD EA 3 .   ? 51.937  5.339   66.495  1.00 38.32  ? ? 
? ? ? 361 NAD B NC7  1 
HETATM 16730 O NO7   . NAD EA 3 .   ? 52.745  6.081   65.939  1.00 39.73  ? ? 
? ? ? 361 NAD B NO7  1 
HETATM 16731 N NN7   . NAD EA 3 .   ? 52.215  4.067   66.753  1.00 41.32  ? ? 
? ? ? 361 NAD B NN7  1 
HETATM 16732 C NC4   . NAD EA 3 .   ? 50.565  7.173   67.689  1.00 34.29  ? ? 
? ? ? 361 NAD B NC4  1 
HETATM 16733 C NC5   . NAD EA 3 .   ? 49.358  7.804   67.923  1.00 33.50  ? ? 
? ? ? 361 NAD B NC5  1 
HETATM 16734 C NC6   . NAD EA 3 .   ? 48.169  7.177   67.588  1.00 35.40  ? ? 
? ? ? 361 NAD B NC6  1 
# 
# 
